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| 1 | Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens显示文摘Background: Limited research has focused on the effect of Lactobacillus on the intestinal toxicity of deoxynivalenol(DON).The present study was conducted to investigate the role of Lactobacillus plantarum(L.plantarum) JM113 in protecting against the intestinal toxicity caused by DON.Methods: A total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments,including the CON(basal diet),the DON(extra 10 mg/kg deoxynivalenol),and the DL(extra 1 × 109 CFU/kg L.plantarum JM113 based on DON group) treatments.The growth performance,organ indexes,intestinal morphology,pancreatic digestive enzymes,intestinal secreted immunoglobulin A(sIgA),jejunal transcriptome,and intestinal microbiota were evaluated.Results: Compared with the CON and DL groups,the DON supplementation altered intestinal morphology,especially in duodenum and jejunum,where villi were shorter and crypts were deeper(P < 0.05).Meanwhile,the significantly decreased mRNA expression of jejunal claudin-1 and occludin(P < 0.05),ileal rBAT and jejunal GLUT1 of 21-day-old broilers(P < 0.05),as well as duodenal PepT1 and ileal rBAT of 42-day-old broilers were identified in the DON group.Moreover,supplementation with L.plantarum JM113 could increase duodenal expression of IL-10 and IL-12 of 21-dayold broilers,ileal s IgA of 42-day-old broilers,and the bursa of Fabricius index of 21-day-old broilers.Further jejunal transcriptome proved that the genes related to the intestinal absorption and metabolism were significantly reduced in the DON group but a significant increase when supplemented with extra L.plantarum JM113.Furthermore,the bacteria related to nutrient utilization,including the Proteobacteria,Escherichia,Cc-115(P < 0.05),Lactobacillus and Prevotella(P < 0.1) were all decreased in the DON group.By contrast,supplementation with L.plantarum JM113 increased the relative abundance of beneficial bacterium,including the Bacteroidetes,Roseburia,Anaerofustis,Anaerostipe,and Ruminococcus bromi(P < 0.05).Specifically,the increased abundance of bacteria in the DL group could be proved by the significantly increased caecal content of propionic acid,n-Butyric acid,and total short-chain fatty acid.Conclusions: L.plantarum JM113 enhanced the digestion,absorption,and metabolic functions of the gut when challenged with DON by reducing the injury to intestinal barriers and by increasing the abundance of beneficial bacterium. | Shengru Wu Yanli Liu Yongle Duan Fangyuan Wang Fangshen Guo Fang Yan Xiaojun Yang Xin Yang | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 7 |
| 2 | Different B-Type Methionine Sulfoxide Reductases in Chlamydomonas May Protect the Alga against High-Light, Sulfur-Depletion, or Oxidative Stress显示文摘The genome of unicellular green alga Chlamydomonas reinhardtii contains four genes encoding B-type methionine sulfoxide reductases,MSRB1.1,MSRB1.2,MSRB2.1,and MSRB2.2,with functions largely unknown.To understand the cell defense system mediated by the methionine sulfoxide reductases in Chlamydomonas,we analyzed expression and physiological roles of the MSRBs under different abiotic stress conditions using immunoblotting and quantitative polymerase chain reaction(PCR)analyses.We showed that the MSRB2.2 protein was accumulated in cells treated with high light(1,300 mE/m2per s),whereas MSRB1.1 was accumulated in the cells under 1 mmol/L H2O2treatment or sulfur depletion.We observed that the cells with the MSRB2.2 knockdown and overexpression displayed increased and decreased sensitivity to high light,respectively,based on in situ chlorophyll a fuorescence measures.We also observed that the cells with the MSRB1.1 knockdown and overexpression displayed decreased and increased tolerance to sulfur-depletion and oxidative stresses,respectively,based on growth and H2-producing performance.The physiological implications revealed from the experimental data highlight the importance of MSRB2.2 and MSRB1.1 in protecting Chlamydomonas cells against adverse conditions such as high-light,sulfur-depletion,and oxidative stresses. | Lei Zhao Mei Chen Dongmei Cheng Haomeng Yang Yongle Sun Heyi Zhou Fang Huang | 2013 | Journal of Integrative Plant Biology2013，55，11： | 2 |
| 3 | Optical pro- perties and photocatalytic activities of spherical ZnO and flower-like ZnO structures synthesized by facile hydrother- mal method 显示文摘 | Fang Yongling Li Zhongyu Xu Song | 2013 | J Alloys Compd2013，575，： | 1 |
| 4 | Prenatal diagnosis of congenital heart defect by genome‐wide high‐resolution SNP array显示文摘 | Can Liao Ru Li Fang Fu Guie Xie Yongling Zhang Min Pan Jian Li Dongzhi Li | 2014 | Prenat Diagn2014，，： | 1 |
| 5 | The Preparation of Porous Activated Slag Granules/TiO_(2)Photocatalyst and Its De-NO_(x)Performance显示文摘The porous structure and honeycombed structure of granulated blast furnace slag formed by alkali activation(AGBFS)can be used as a promising photocatalysts substrate for the photocatalytic removal of atmospheric or water pollutants.In this study,photocatalytic activated slag granules were synthesized by loading TiO_(2)on AGBFS with immersion method.The physicochemical properties and NO_(x)removal performance of activated slag granules/TiO_(2)photocatalysts were studied by X-ray diffraction(XRD),scanning electron microscope(SEM)and photocatalytic performance test.The effects of slag particle sizes and nano-TiO_(2)loading concentrations on photocatalytic efficiencies of NO_(x)removal were also investigated.It was found that the De-NO_(x)performance of activated slag granules/TiO_(2)photocatalyst increased with the increasing of slag particle size in low TiO_(2)loading concentration situation,while increasing the TiO_(2)loading concentration would result in the opposite De-NO_(x)performance as slag size increased.Nevertheless,for the same size activated slag,the photocatalytic efficiency of activated slag granules/TiO_(2)photocatalyst gradually improved with the increase of loading concentration of TiO_(2). | 朱立德 CHEN Jing SI Heyang FANG Yongle WANG Xinyu WANG Zongsen 杨露 | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 0 |
| 6 | IN BRIEF显示文摘PetroChina president changed PetroChina appointed Zhou Jiping president and vice-chairman of the company in mid-May, elevating him | Gu Xingyuan Fang Yongling | 2015 | China Oil & Gas2015，22，2： | 0 |
| 7 | IN BRIEF显示文摘Chinese tankers to carry US shale gas to Europe Two gas tankers built by the Sinopacific Offshore and Engineering will ship shale gas to Europe from the United States.The ships will join an eventual eightstrong fleet of tankers operated by | Gu Xingyuan Fang Yongling | 2015 | China Oil & Gas2015，22，3： | 0 |
| 8 | Introduction of nanotwins into nanoprecipitations strengthened CoCrNiMo_(0.2) alloy to achieve strength and ductility trade-off:A comparative research显示文摘Normal strengthening methods through precipitations and deformation obviously enhance the strength of metallic materials while resulting in the sacrifice of ductility,and synergistic improvement of strength and ductility is currently an urgent requirement.Herein we developed a cryogenic deformation combined with an annealing method to fabricate CoCrNiMo_(0.2) medium entropy alloy,which achieved an ultrahigh strength of 1.8 GPa with synergistic improvement in strength and ductility.Microstructure,mechanical performance,and strengthening mechanisms of the developed alloys were investigated compared with that prepared by the regular room temperature deformation method.It was found that high-density nanotwins were produced in CoCrNiMo_(0.2) MEA via cryogenic deformation.Fine grains,hard precipitations,and high volume fraction of nanotwins greatly strengthened the alloy,obtaining a yield and ultimate tensile strength of 1400 MPa and 1800 MPa.Ductility improvement of the developed alloy was mainly attributed to the production of deformation nanotwins due to the lower stacking fault energy,which greatly increases the dislocation storage ability,and thus,the ductility of the alloy was enhanced. | Hao Zhang Ziyi Ren Yonggang Tong Yongle Hu Xixi Ji Lingwei Yang Kaiming Wang Jingzhong Fang Hui Chen Xiubing Liang | 2023 | Journal of Materials Science & Technology2023，，25： | 0 |
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