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| 1 | Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation显示文摘 | Yutaka Sakakibara Kazunobu Nishimura Keiichi Tambara Masaya Yamamoto Fanglin Lu Yasuhiko Tabata Masashi Komeda | 2002 | The Journal of Thoracic and Cardiovascular Surgery2002，，1： | 1 |
| 2 | Transplanted Skeletal Myoblasts Can Fully Replace the Infarcted Myocardium When They Survive in the Host in Large Numbers显示文摘 | Keiichi Tambara Yutaka Sakakibara Genichi Sakaguchi Fanglin Lu Goditha U. Premaratne Xue Lin Kazunobu Nishimura Masashi Komeda | 2003 | Circulation: Journal of the American Heart Association ( Suppl II)2003，，10： | 1 |
| 3 | Numerical modeling and theoretical analysis of femtosecond laser tweezers显示文摘 | Qirong Xing Fanglin Mao Lu Chat | | Opttcs& Laser technology0，，： | 1 |
| 4 | MIR137 gene and target gene CACNA1C of miR-137 contribute to schizophrenia susceptibility in Han Chinese显示文摘 | Fanglin Guan Bo Zhang Tinglin Yan Lu Li Fei Liu Tao Li Zufei Feng Bao Zhang Xinshe Liu Shengbin Li | 2013 | Schizophrenia Research2013，，： | 1 |
| 5 | Seasonal and extraseasonal predictions of summer monsoon precipitation by gems(1)显示文摘 | Zeng Qingcun Yuan Chongguang Li Xu Zhang Ronghua Yang Fanglin Zhang Banglin Lu Peisheng Bi Xunqiang Wang Huijun | 1997 | Advances in Atmospheric Sciences1997，，2： | 1 |
| 6 | Seasonal and extraseasonal predictions of summer monsoon precipitation by gems(1)显示文摘 | Zeng Qingcun Yuan Chongguang Li Xu Zhang Ronghua Yang Fanglin Zhang Banglin Lu Peisheng Bi Xunqiang Wang Huijun | 1997 | Advances in Atmospheric Sciences1997，，2： | 1 |
| 7 | Effect of Asafoetida Ex- tract on Growth and Quality of Pleurotus ferulic显示文摘 | Zuoshan Feng Yujia Bai Fanglin Lu | 2010 | International Journal of Molecular Sciences2010，，11： | 1 |
| 8 | Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation显示文摘 | Yutaka Sakakibara Kazunobu Nishimura Keiichi Tambara Masaya Yamamoto Fanglin Lu Yasuhiko Tabata Masashi Komeda | 2002 | The Journal of Thoracic and Cardiovascular Surgery2002，，1： | 1 |
| 9 | Arginase 2 negatively regulates sorafenib-induced cell death by mediating ferroptosis in melanoma显示文摘Ferroptosis,a newly defined and iron-dependent cell death,morphologically and biochemically differs from other cell deaths.Melanoma is a serious type of skin cancer,and the poor efficacy of current therapies causes a major increase in mortality.Sorafenib,a multiple kinase inhibitor,has been evaluated in clinical phase trials of melanoma patients,which shows modest efficacy.Emerging evidence has demonstrated that arginase 2(Arg2),type 2 of arginase,is elevated in various types of cancers including melanoma.To investigate the role and underlying mechanism of Arg2 in sorafenib-induced ferroptosis in melanoma,reverse transcriptase-quantitative polymerase chain reaction,western blot analysis,adenovirus and lentivirus transduction,and in vivo tumor homograft model experiments were conducted.In this study,we show that sorafenib treatment leads to melanoma cell death and a decrease in Arg2 at both the mRNA and protein levels.Knockdown of Arg2 increases lipid peroxidation,which contributes to ferroptosis,and decreases the phosphorylation of Akt.In contrast,overexpression of Arg2 rescues sorafenib-induced ferroptosis,which is prevented by an Akt inhibitor.In addition,genetic and pharmacological suppression of Arg2 is able to ameliorate the anticancer activity of sorafenib in melanoma cells in vitro and in tumor homograft models.We also show that Arg2 suppresses ferroptosis by activating the Akt/GPX4 signaling pathway,negatively regulating sorafenib-induced cell death in melanoma cells.Our study not only uncovers a novel mechanism of ferroptosis in melanoma but also provides a new strategy for the clinical applications of sorafenib in melanoma treatment. | Yi Yu Yuanyuan Ren Caihua Wang Zhuozhuo Li Fanglin Niu Zi Li Qiang Ye Jiangxia Wang Yuan Yan Ping Liu Lu Qian Yuyan Xiong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 0 |
| 10 | Synthesis of Fluorene Derivatives Via TfOH-catalyzed Intramolecular Friedel-Crafts Alkylation Reactions显示文摘We devoloped an efficient and simple method to synthesize fluorene derivatives via intramolecular Friedel-Crafts alkylation of chalcones.The transform is catalyzed by TfOH in CH_(3)NO_(2)at 80℃and the yield is up to 99%. | ZHOU Ziyang YI Ying ZHANG Fanglin XU Wengang LU Zhi LUO Tian | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，5： | 0 |
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