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您的检索式：作者名="Fanming Yang"
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| 1 | Observation of electron weak localization and correlation effects in disordered graphene显示文摘We have studied the electron transport properties of a disordered graphene sample, where the disorder was intentionally strengthened by Ga+ ion irradiation. The magneto-conductance of the sample exhibits a typical two-dimensional electron weak localization behavior, with electron-electron interaction as the dominant dephasing mechanism. The absence of electron anti-weak localization in the sample implies strong intersublattice and/or intervalley scattering caused by the disorders. The temperature and bias-voltage dependencies of conductance clearly reveal the suppression of conductance at low energies, indicating opening of a Coulomb gap due to electron-electron interaction in the disordered graphene sample. | TAN ChangLing TAN ZhenBing MA Li QU FanMing YANG Fan CHEN Jun LIU GuangTong YANG HaiFang YANG ChangLi LU Li | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，9： | 1 |
| 2 | Traditional Chinese medicines for non-small cell lung cancer: Therapies and mechanisms显示文摘The most common subtype of lung cancer is non-small cell lung cancer(NSCLC), which has a poor prognosis and seriously threatens the health of human beings. The multidisciplinary comprehensive treatment model has gradually become the mainstream of NSCLC treatment. Traditional Chinese medicine(TCM) can be used effectively either as an adjunctive therapy or alone throughout the NSCLC therapy,which has a significant impact on survival, quality of life, and reduction of toxicity. Therefore, this paper reviewed the theoretical basis, the latest clinical application, and combined treatment mechanisms in order to explore the advantage stage of TCM treatment and the synergistic therapeutic mechanisms. | Fanming Kong Chaoran Wang Linlin Zhao Dongying Liao Xiaoqun Wang Binxu Sun Peiying Yang Yingjie Jia | 2023 | Chinese Herbal Medicines2023，15，4： | 0 |
| 3 | Extending the L1 region in canonical double-stranded RNA-binding domains impairs their functions显示文摘A large number of proteins involved in RNA metabolism possess a double-stranded RNA-binding domain(dsRBD),whose sequence variations and functional versatilities are still being recognized.All dsRBDs have a similar structural fold:α1-L1-β1-L2-β2-L3-β3-L4-α2(αrepresents anα-helix,βaβ-sheet,and L a loop conformation between the well-defined secondary structures).Our recent work revealed that the dsRBD in Drosha,which is involved in animal microRNA(miRNA)biogenesis,differs from other dsRBDs by containing a short insertion in its L1 region and that this insertion is important for Drosha function.We asked why the same insertion is excluded in all other dsRBDs and proposed that a longer L1 may be detrimental to their functions.In this study,to test this hypothesis,we inserted the Drosha sequence into several well-known dsRBDs from various organisms.Gel mobility shift assay demonstrated that L1 extension invariably reduced RNA binding by these dsRBDs.In addition,such a mutation in Dicer,another protein involved in miRNA biogenesis,impaired Dicer’s ability to process miRNAs,which led to de-repression of reporter expression,in human cells.Taken together,our results add to the growing appreciation of the diversity in dsRBDs and suggest that dsRBDs have intricate structures and functions that are sensitive to perturbations in the L1 region. | Xiaoxiao Zhang Peng Li Huanhuan Zhong Fanming Yang Fanzhou Liu Gabriel Yedid Yan Zeng | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
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