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| 1 | China's lakes at present:Number,area and spatial distribution显示文摘Based on 11004 satellite images from CBERS CCD and Landsat TM/ETM,changes in the spatial characteristics of all lakes in China were determined following pre-established interpretation rules.This dataset was supported by 6843 digital raster images(1:100000 and 1:50000),a countrywide digital vector dataset(1:250000),and historical literature.Comparative data were corrected for seasonal variations using precipitation data.There are presently 2693 natural lakes in China with an area greater than 1.0 km2,excluding reservoirs.These lakes are distributed in 28 provinces,autonomous regions and municipalities and have a total area of 81414.6 km2,accounting for-0.9% of China's total land area.In the past 30 years,the number of newly formed and newly discovered lakes with an area greater than 1.0 km2 is 60 and 131,respectively.Conversely,243 lakes have disappeared in this time period. | MA RongHua YANG GuiShan DUAN HongTao JIANG JiaHu WANG SuMin FENG XueZhi LI AiNong KONG FanXiang XUE Bin WU JingLu LI ShiJie | 2011 | Science China Earth Sciences2011，54，2： | 79 |
| 2 | Seasonal variation of Microcystis in Lake Taihu and its relationships with environmental factors显示文摘In order to monitor the changes of Microcystis along with temporal and spatial variations, seasonal variation of Microcystis in Lake Taihu was investigated by 16S-23S rRNA internal transcribed spacer denaturing gradient gel electrophoresis (16S-23S rRNA-ITS DGGE) and microscopic evaluation. Samples were collected quarterly at four sites (River Mouth, Meiliang Bay, Cross Area, and Lake Center) from August 2006 to April 2007. Results showed that Microcystis dominated total phytoplankton abundance at the four sites in all seasons except winter. The average annual abundance of Microcystis was relatively high at River Mouth and Meiliang Bay, reaching 81.22 × 106 and 61.32 × 106 cells/L, respectively. For temporal variations, Shannon-Wiener diversity index (H ) according to DGGE profile revealed the richness of Microcystis in summer (H = 1.375 ± 0.034) and winter (H = 1.650 ± 0.032) was lower than that in spring (H = 2.078 ± 0.031) and autumn (H = 2.365 ± 0.032) (P < 0.05). While for spatial variations, the richness of Microcystis at River Mouth (H = 2.015 ± 0.074) was higher than at other sites during four seasons (P < 0.01). Very few dierences of Microcystis diversity in the same season were observed among the other three sites (P > 0.05). Canonical correspondence analysis (CCA) was performed to elucidate the relationships between Microcystis operational taxonomic units (OTUs) composition and the environmental factors. Results of CCA revealed that temperature was strongly positively correlated with the first axis (r = 0.963), while TSS was negative correlated with the second axis (r = -0.716). Phylogenetic tree based on the sequencing results of target bands on DGGE gel indicated that samples collected in summer and winter constituted two separated clusters. | TAN Xiao KONG Fanxiang ZENG Qingfei CAO Huansheng QIAN Shanqin ZHANG Min | 2009 | Journal of Environmental Sciences2009，21，7： | 16 |
| 3 | Phylogenetic diversity and specificity of bacteria associated with Microcystis aeruginosa and other cyanobacteria显示文摘Interactions between bacteria and cyanobacteria have been suggested to have a potential to influence harmful algal bloom dynamics; however, little information on these interactions has been reported. In this study, the bacterial communities associated with five strains of Microcystis aeruginosa, three species of other Microcystis spp., and four representative species of non-Microcystis cyanobacteria were compared. Bacterial 16S rDNA fragments were amplified and separated by denaturing gradient gel electrophoresis (DGGE) followed by DNA sequence analysis. The similarities among bacterial communities associated with these cyanobacteria were compared to the digitized DGGE profiles using the cluster analyses. The bacterial community structure of all cyanobacterial cultures differed. Cluster analysis showed that the similarity values among M. aeruginosa cultures were higher than those of other cyanobacterial cultures. Sequence analysis of DGGE fragments indicated the presence of bacteria including, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Bacteroidetes and Actinobacteria in the cyanobacterial cultures. Members of the Sphingomonadales were the prevalent group among the Microcystis-associated bacteria. The results provided further evidence for species-specific associations between cyanoabcteria and heterotrophic bacteria, which are useful for understanding interactions between Microcystis and their associated bacteria. | SHI Limei CAI Yuanfeng YANG Hualin XING Peng LI Pengfu KONG Lingdong KONG Fanxiang | 2009 | Journal of Environmental Sciences2009，21，11： | 11 |
| 4 | Induction of apoptosis by casticin in cervical cancer cells: reactive oxygen species-dependent sustained activation of Jun N-terminal kinase显示文摘Casticin,从 Fructus viticis 的 polymethoxyflavone 在中国传统的药用作一个反煽动性的代理人,被报导了有反癌症活动。这研究的目的是在人的颈的癌症房间和它的分子的机制上检验 casticin 的 apoptotic 活动。我们揭示了导致 casticin 的 apoptosis 由发生的新奇机制并且第一次证明 casticin 导致的 apoptosis 通过反应的氧种类(ROS ) 的产生被调停并且在 HeLa 细胞支撑了 c6 月 N 终端 kinase (JNK ) 的激活。Casticin 显著地增加了细胞内部的 ROS 的层次并且导致了 phosphorylated JNK 和 c6 月蛋白质的表示。有 N-acetylcysteine 和 SP600125 的预告的处理有效地在 HeLa 房间由 casticin 稀释了 apoptosis 的正式就职。而且, casticin 在另外的颈的癌症房间线导致了 ROS 生产和 apoptotic 房间死亡,例如 CasKi 和 SiHa。重要地, casticin 没在正常的人的外部血 mononuclear 房间和胚胎的肾上皮引起 ROS 的产生或 apoptosis 的正式就职 293 个房间。这些结果建议由 casticin 的 ROS 产生和持续 JNK 激活在导致 casticin 的 apoptosis 起一个作用并且提起有 casticin 的治疗可能作为对人的颈的癌症的新治疗有希望的可能性。 | Fanxiang Zeng Li Tian Fei Liu Jianguo Cao Meifang Quan Xifeng Sheng | 2012 | Acta Biochimica et Biophysica Sinica2012，44，5： | 9 |
| 5 | Growth characteristics of algae during early stages of phytoplankton bloom in Lake Taihu,China显示文摘Three treatments, sediment plus lake water (S+W), sterilized sediment plus lake water (SS+W), and sediment plus filtered lake water (S+FW), were recruited to investigate the growth characteristics of algae during pre-bloom and the importance of algal inocula in the water column and sediment. The results showed that in the water column, biomass of all algae increased in all treatments when recruitment was initiated, whereas this tendency differed among treatments with further increment of temperature. The process of algal growth consisted of two stages: Stage I, the onset of recruitment and Stage II, the subsequent growth of algae. Compared with S+W, in Stage I, SS+W significantly increased the biomass of cyanophytes by 178.70%, and decreased the biomass of non-cyanophytes by 43.40%; In Stage II, SS+W notably stimulated the growth of all algae, thus incurring the occurrence of phytoplankton bloom. Further analyses revealed that both metabolic activity and photochemical activity of algae were enhanced in SS+W, which resulted from the releasing of nutrients from sediment. These results suggest that algal growth in Stage II and algal inocula in the water column can be important factors for the formation of phytoplankton bloom. In addition, possible mechanisms promoting algal recruitment and subsequent growth of algae were explored. | Yuhong Jia Johnson Dan Min Zhang Fanxiang Kong | 2013 | Journal of Environmental Sciences2013，25，2： | 6 |
| 6 | Quantification of microcystin-producing and non-microcystin producing Microcystis populations during the 2009 and 2010 blooms in Lake Taihu using quantitative real-time PCR显示文摘Lake Taihu,a large,shallow hypertrophic freshwater lake in eastern China,has experienced lake-wide toxic cyanobacterial blooms annually during summer season in the past decades.Spatial changes in the abundance of hepatotoxin microcystin-producing and nonmicrocystin producing Microcystis populations were investigated in the lake in August of 2009 and 2010.To monitor the densities of the total Microcystis population and the potential microcystin-producing subpopulation,we used a quantitative real-time PCR assay targeting the phycocyanin intergenic spacer(PC-IGS) and the microcystin synthetase gene(mcyD),respectively.On the basis of quantification by real-time PCR analysis,the abundance of potential toxic Microcystis genotypes and the ratio of the mcyD subpopulation to the total Microcystis varied significantly,from 4.08×104 to 5.22×107 copies/mL,from 5.7% to 65.8%,respectively.Correlation analysis showed a strong positive relationship between chlorophyll-a,toxic Microcystis and total Microcystis;the abundance of toxic Microcystis correlated positively with total phosphorus and ortho-phosphate concentrations,but negatively with TN:TP ratio and nitrate concentrations.Meanwhile the proportion of potential toxic genotypes within Microcystis population showed positive correlation with total phosphorus and ortho-phosphate concentrations.Our data suggest that increased phosphorus loading may be a significant factor promoting the occurrence of toxic Microcystis bloom in Lake Taihu. | Daming Li Fanxiang Kong Xiaoli Shi Linlin Ye Yang Yu Zhen Yang | 2012 | Journal of Environmental Sciences2012，24，2： | 5 |
| 7 | Spatial heterogeneity of cyanobacterial communities and genetic variation of Microcystis populations within large,shallow eutrophic lakes(Lake Taihu and Lake Chaohu,China)显示文摘Cyanobacteria,specifically Microcystis,usually form massive blooms in eutrophic freshwater lakes.Cyanobacterial samples were collected from eight sites of both Lake Taihu and Lake Chaohu in late summer to determine the diversity and distribution pattern of cyanobacteria and Microcystis in large,shallow,entropic lakes with significant spatial heterogeneity and long-term Microcystis bloom.Molecular methods based on denaturing gradient gel electrophoresis and clone library analysis were used.A similar heterogeneous distribution pattern of cyanobacteria in both lakes was observed.Most parts of these two lakes with high trophic level were dominated by Microcystis.However,in the regions with low trophic levels as well as low concentrations of chlorophyll a,Synechococcus occupied a considerable percentage.Different morphospecies and genotypes dominated the bloom-forming Microcystis populations in these two lakes.Microcystis viridis and Microcystis novacekii were dominant in Lake Chaohu,whereas Microcystis flos-aquae was dominant in Lake Taihu.Only 2 of the13 Microcystis operational taxonomic units were shared between these two lakes.Analysis of molecular variance based on 16S to 23S internal transcribed spacer sequences indicated the significant genetic differentiation of Microcystis between these two lakes(F st = 0.19,p < 0.001).However,only 19.46% of the genetic variability was explained by the population variation between lakes,whereas most(80.54%) of the genetic variability occurred within the lakes.Phylogenetic analysis revealed no phylogeographic structure of Microcystis population in these two lakes,as illustrated by their cosmopolitan nature.Our results revealed that spatial heterogeneity within lakes has more impact on the cyanobacterial diversity than geographical isolation in a local scale. | Yuanfeng Cai Fanxiang Kong Limei Shi Yang Yu | 2012 | Journal of Environmental Sciences2012，24，10： | 5 |
| 8 | Effects of elevated CO_2 on dynamics of microcystin-producing and non-microcystin-producing strains during Microcystis blooms显示文摘In an attempt to elucidate the effects of different CO2concentrations(270, 380, and 750 μL/L) on the competition of microcystin-producing(MC-producing) and non-MC-producing Microcystis strains during dense cyanobacteria blooms, an in situ simulation experiment was conducted in the Meiliang Bay of Lake Taihu in the summer of 2012. The abundance of total Microcystis and MC-producing Microcystis genotypes was quantified based on the 16 S r DNA and mcy D gene using real-time PCR. The results showed that atmospheric CO2 elevation would significantly decrease the p H value and increase the dissolved inorganic carbon(DIC) concentration.Changes in CO2 concentration did not show significant influence on the abundance of total Microcystis population. However, CO2 concentrations may be an important factor in determining the subpopulation structure of Microcystis. The enhancement of CO2 concentrations could largely increase the competitive ability of non-MC-producing over MC-producing Microcystis, resulting in a higher proportion of non-MC-producing subpopulation in treatments using high CO2 concentrations. Concurrently, MC concentration in water declined when CO2 concentrations were elevated. Therefore, we concluded that the increase of CO2 concentrations might decrease potential health risks of MC for human and animals in the future. | Li Yu Fanxiang Kong Xiaoli Shi Zhen Yang Min Zhang Yang Yu | 2015 | Journal of Environmental Sciences2015，27，1： | 4 |
| 9 | Cloud model-based analysis of regional sustainable water resource utilization schemes显示文摘Given the adverse effects of current water shortages,low utilization and imbalance between the supply and demand,and other status quo problems relating to social economic development,the construction industry and agriculture,a cloud model was applied to a water resource system using five sustainable water resource utilization schemes for Kiamusze,Heilongjiang Province,as an example.This research changes the qualitative description of the concept language into a quantitative analysis of an evaluation indicator.A cloud model-based analytical method for regional sustainable water resource utilization schemes was proposed,and the sustainable grades of the water resources were calculated.The research results showed that,in addition to the natural continuation of such schemes,the development trends of four new schemes achieved the sustainable utilization of water resources,and thus,the sustainable water resource utilization was optimized.However,when the open-source,throttle,comprehensive and coordination schemes were subjected to the optimum applicability analysis,based on the limiting factors in different periods,resource availability and long-term development,decision-making regarding the best solution in different periods better ensures sustainable development in Kiamusze.The research results provide a significant theoretical basis for the formulation of scientific and reasonable sustainable water resource utilization strategies in Kiamusze. | Fu Qiang Meng Fanxiang Li Tianxiao Liu Dong Gong Fanli Amgad Osman Li Yutong | 2016 | International Journal of Agricultural and Biological Engineering2016，9，5： | 4 |
| 10 | Genetic Diversity of Eukaryotic Microorganisms in Lake Taihu, a Large Shallow Subtropical Lake in China显示文摘 | Meijun Chen Feizhou Chen Yang Yu Jian Ji Fanxiang Kong | 2008 | Microbial Ecology2008，，3： | 1 |
| 11 | Specific association between bacteria and buoyant M icrocystis colonies compared with other bulk bacterial communities in the eutrophic L ake T aihu, C hina显示文摘 | Limei Shi Yuanfeng Cai Fanxiang Kong Yang Yu | 2012 | Environmental Microbiology Reports2012，，6： | 1 |
| 12 | Effects of wind and wind-induced waves on vertical phytoplankton distribution and surface blooms of Microcystis aeruginosa in Lake Taihu显示文摘 | CAO Huansheng KONG Fanxiang LUO Liancong | 2006 | Journal of Freshwater Ecology2006，21，2： | 1 |
| 13 | Robust and efficient visual tracking under illumination changes based on maximum color difference histogram and min-max-ratio metric显示文摘 | Zeng Fanxiang Liu Xuan Huang Zhitong | 2013 | J Electron Imaging2013，22，04： | 1 |
| 14 | Effects of copper,manganese and pH on the growth and several enzyme activities of mycorrhizal fungus Cenococcum geophilum Fr.显示文摘Effectsofcopper,manganeseandpHonthegrowthandseveralenzymeactivitiesofmycorrhizalfungusCenococcumgeophilumFr.￥KongFanxiang;Zha... | Kong Fanxiang Zhang Min(Department of Environmental Science and Engineering, Nanjing University,Nanjing 210093,China) | 1996 | Journal of Environmental Sciences1996，8，4： | 1 |
| 15 | Novel dual inhibitor for targeting PIM1 and FGFR1 kinases inhibits colorectal cancer growth in vitro and patient-derived xenografts in vivo显示文摘Colorectal cancer(CRC) is the second most common cause of cancer-related death in the world. The pro-viral integration site for Moloney murine leukemia virus 1(PIM1) is a proto-oncogene and belongs to the serine/threonine kinase family, which are involved in cell proliferation, migration,and apoptosis. Fibroblast growth factor receptor 1(FGFR1) is a tyrosine kinase that has been implicated in cell proliferation, differentiation and migration. Small molecule HCI-48 is a derivative of chalcone, a class of compounds known to possess anti-tumor, anti-inflammatory and antibacterial effects. However,the underlying mechanism of chalcones against colorectal cancer remains unclear. This study reports that HCI-48 mainly targets PIM1 and FGFR1 kinases, thereby eliciting antitumor effects on colorectal cancer growth in vitro and in vivo. HCI-48 inhibited the activity of both PIM1 and FGFR1 kinases in an ATPdependent manner, as revealed by computational docking models. Cell-based assays showed that HCI-48inhibited cell proliferation in CRC cells(HCT-15, DLD1, HCT-116 and SW620), and induced cell cycle arrest in the G2/M phase through modulation of cyclin A2. HCI-48 also induced cellular apoptosis, as evidenced by an increase in the expression of apoptosis biomarkers such as cleaved PARP, cleaved caspase 3 and cleaved caspase 7. Moreover, HCI-48 attenuated the activation of downstream components of the PIM1 and FGFR1 signaling pathways. Using patient-derived xenograft(PDX) murine tumor models,we found that treatment with HCI-48 diminished the PDX tumor growth of implanted CRC tissue expressing high protein levels of PIM1 and FGFR1. This study suggests that the inhibitory effect of HCI-48 on colorectal tumor growth is mainly mediated through the dual-targeting of PIM1 and FGFR1kinases. This work provides a theoretical basis for the future application of HCI-48 in the treatment of clinical CRC. | Fanxiang Yin Ran Zhao Dhilli Rao Gorja Xiaorong Fu Ning Lu Hai Huang Beibei Xu Hanyong Chen Jung-Hyun Shim Kangdong Liu Zhi Li Kyle Vaughn Laster Zigang Dong Mee-Hyun Lee | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 1 |
| 16 | Dynamics of dissolved organic carbon after a cyanobacterial bloom in hypereutrophic Lake Taihu (China)显示文摘 | Linlin Ye Xiao Shi Xiaodong Wu Min Zhang Yang Yu Daming Li Fanxiang Kong | 2011 | Limnologica2011，，4： | 1 |
| 17 | Survival of Microcystis aeruginosa and Scenedesmus obliquus under dark anaerobic condition显示文摘 | SHI Xiaoli KONG Fanxiang YU Yang | 2007 | Marine and Freshwater Research2007，58，7： | 1 |
| 18 | Effects of interspecific interactions between Microcystis aeruginosa and Chlorella pyrenoidosa on their growth and physiology显示文摘 | Zhang M Kong Fanxiang Xing Peng | 2007 | International Review of Hydrobiology2007，92，3： | 1 |
| 19 | Recruitment of total phytoplankton, chlorophytes and cyanobacteria from lake sediments recorded by photosynthetic pigments in a large, shallow lake (Lake Taihu, China) 显示文摘 | CAO Huansheng KONG Fanxiang TAN Jiankang | 2005 | Internal Rev Hydrobiol2005，90，4： | 1 |
| 20 | Changes in the morphology and polysaeeharide content of Microcystis aeruginosa (Cyanobacteria) during flagellate grazing 显示文摘 | YANG Zhou KONG Fanxiang SHI Xiaoli | 2008 | Journal of Phyeology2008，44，3： | 1 |
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