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| 1 | Numerical and experimental investigation on dynamic performance of bump foil journal bearing based on journal orbit显示文摘Widespread usage of bump-type foil journal bearing(BFJB) in oil-free microturbomachinery requires accurate predictions of dynamic performance characteristics, although it remains a challenging issue because BFJB reflects nonlinear both structurally and aerodynamically.This paper presented a simple experimental method to semi-directly obtain the minimum film thickness and dynamic stiffness of BFJB using the journal orbit. Numerical calculations and simulations are conducted to validate the experimental method. The micro-deformation and interaction of various foils are taken into consideration to improve the model precision. The results from the numerical model regarding the BFJB dynamic characteristics are compared with the experimental results coming from a dedicated test rig, which shows that the experimental results fluctuate obviously and agree not well with the numerical results at the start stage due to the presence of dry friction at that time, nevertheless, they show fantastic agreement as soon as a gas film is gradually generated to separate the shaft from the top foil. Therefore, the proposed experimental method is effective to predict film thickness and dynamic characteristics during the period from the lift-off time to the land-off time. The dynamic characteristics, along with the journal orbits also can be used to rapidly predict the dynamics behavior of rotor-bearing systems. | Yu ZHOU Longtao SHAO Can ZHANG Fenzhu JI Jiang LIU Guo LI Shuiting DING Qi ZHANG Farong DU | 2021 | Chinese Journal of Aeronautics2021，34，2： | 6 |
| 2 | Effects of Maca Extract on Exercise Endurance and Ultrastructure of Mitochondria in Spinal Neurons显示文摘[Objectives] To study the effects of maca extract on the exercise endurance and ultrastructure of mitochondria in spinal neurons.[Methods]First,50 Wistar rats were randomly divided into 5 groups. The control group: no swimming,administered intragastrically the same volume of distilled water; simple swimming group: free swimming,administered intragastrically the same volume of distilled water; maca extract groups: free swimming,and treated with 4. 0,5. 3,and 8. 0 g/kg dose of maca extracts. Swimming rats swam freely in the circulating water flow of swimming pool and administered for 15 d. On the 16 th d,after the swimming endurance test,the rats were killed painlessly. The ultrastructure of the mitochondria in the spinal neurons was observed with a projection electron microscope,muscle glycogen,malondialdehyde( MDA),superoxide dismutase( SOD),glutathione peroxidase( GSH-Px) and free calcium in muscle were measured by radioimmunoassay.[Results] Compared with the simple swimming group,the swimming time before sinking and total swimming time extended 19. 83%,60. 28%,77. 55% and 55. 34%,73. 91% and 94. 47% respectively,and the differences were statistically significant( P < 0. 01). The sinking times decreased by 34. 35%,51. 18% and 57. 96% respectively,the differences were statistically significant( P < 0. 01). MDA and free calcium decreased by 20. 10%,31. 49% and 38. 72%,respectively with statistically significant differences( P < 0. 01) and 6. 42%,17. 58%and 26. 35% respectively. The levels of SOD,GSH-Px and muscle glycogen increased by 5. 12%,22. 74%,52. 53%,44. 22%,77. 79%and 98. 45% respectively,with statistically significant differences( P < 0. 01) and 35. 08%,47. 83% and 81. 88%,respectively,with statistically significant differences( P < 0. 01). The volume density( Vd),surface density( Sd) and number density( Nd) of mitochondria of spinal neurons decreased by 7. 79%,18. 18%,31. 17%,16. 95%,27. 34%,43. 31% and 13. 51%,23. 19% and 43. 15% respectively.[Conclusions]Maca extract can protect ultrastructure of the mitochondria in the spinal neurons,antioxidant activity,increase muscle glycogen,and improving the exercise capacity. | Farong YU Wangjun CHEN Xiuzhen LIAN Mingren XIE Denglou LI Yunxuan GUO | 2018 | Medicinal Plant2018，9，3： | 3 |
| 3 | Effect of scavenge port angles on flow distribution and performance of swirl-loop scavenging in 2-stroke aircraft diesel engine显示文摘Swirl-Loop Scavenging(SLS) improves the performance of 2-stroke aircraft diesel engine because the involved swirl may not only benefit the scavenging process, but also facilitate the fuel atomization and combustion. The arrangement of scavenge port angles greatly influences incylinder flow distribution and swirl intensity, as well as the performance of the SLS engine. However, the mechanism of the effect and visualization experiment are rarely mentioned in the literature. To further investigate the SLS, Particle Image Velocimetry(PIV) experiment and Computational Fluid Dynamics(CFD) simulation are adopted to obtain its swirl distribution characteristics, and the effect of port angles on scavenging performance is discussed based on engine fired cycle simulation. The results illustrate that Reynolds Stress Turbulence model is accurate enough for in-cylinder flow simulation. Tangential and axial velocity distribution of the flow, as well as the scavenging performance, are mainly determined by geometric scavenge port angles ageom and βgeom . For reinforcement of scavenging on cross-sections and meridian planes, ageomvalue of27° and βgeom value of 60° are preferred, under which the scavenging efficiency reaches as high as 73.7%. Excessive swirl intensity has a negative effect on SLS performance, which should be controlled to a proper extent. | Zheng XU Fenzhu JI Shuiting DING Yunhai ZHAO Yu ZHOU Qi ZHANG Farong DU | 2021 | Chinese Journal of Aeronautics2021，34，3： | 3 |
| 4 | ALGORITHM OF PRETREATMENT ON AUTOMOBILE BODY POINT CLOUD显示文摘作为一整个车辆的点云,身体有大几何尺寸,巨大的数据和严密反向的精确的特点,汽车身体点云上的一个预告的处理算法被提出。登记算法的基本想法基于骨骼点是构造整个车辆模型的骨骼点和分开的点云的标记点,为了寻找在骨骼点和标记之间的印射的关系,用一致三角方法并且到整个车辆点遮蔽使用改进的反复的关上的点( ICP )的火柴指算法。基于距离的平均的方形的根,数据减小算法压缩在三的数据走,计算数据集距离 ins ampling 立方体格子的平均的方形的根,根据从第一步计算的值排序顺序,选采样为百分比。上面的二个算法的精确性被登记和某个轻卡车的整个车辆点云的减小例子证明。 | GAO Feng ZHOU Yu DU Farong QU Weiwei XIONG Yonghua | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 2 |
| 5 | Preparation and Properties of Silicon-Containing Arylacetylene Resin/Benzoxazines Blends显示文摘 | Gao Yu Zhou Yan Huang Farong | 2013 | High Perform Polym2013，25，4： | 1 |
| 6 | Research and development on the China low activation martensitic steel (CLAM)显示文摘 | YU Jinnan HUANG Qunying WAN Farong | 2007 | J Nucl Mater2007，，： | 1 |
| 7 | Effects of immediate stimulation on single nucleotide and catecholamine level in Chinese tree shrews显示文摘 | Yu Farong Lian Xiuzhen Xie Mingren | 2014 | Advanced Materials Reseach2014，，： | 1 |
| 8 | Investigation into gas lubrication performance of porous gas bearing considering velocity slip boundary condition显示文摘Porous gas bearings(PGBs)have a proactive application in aerospace and turbomachinery.This study investigates the gas lubrication performance of a PGB with the condition of velocity slip boundary(VSB)owing to the high Knudsen number in the gas film.The Darcy-Forchheimer laws and modified Navier-Stokes equations were adopted to describe the gas flow in the porous layer and gas film region,respectively.An improved bearing experimental platform was established to verify the accuracy of the derived theory and the reliability of the numerical analysis.The effects of various parameters on the pressure distribution,flow cycle,load capacity,mass flow rate,and velocity profile are demonstrated and discussed.The results show that the gas can flow in both directions,from the porous layer to the gas film region,or in reverse.The load capacity of the PGB increases with an increase in speed and inlet pressure and decreases with an increase in permeability.The mass flow rate increases as the inlet pressure and permeability increase.Furthermore,the simulation results using VSB are in agreement with the experimental results,with an average error of 3.4%,which indicates that the model using VSB achieves a high accuracy.The simulation results ignoring the VSB overrate the load capacity by 16.42%and undervalue the mass flow rate by 11.29%.This study may aid in understanding the gas lubrication mechanism in PGBs and the development of novel gas lubricants. | Xiangbo ZHANG Shuiting DING Farong DU Fenzhu JI Zheng XU Jiang LIU Qi ZHANG Yu ZHOU | 2022 | Friction2022，10，6： | 1 |
| 9 | Revealing Functional Significance of Interleukin-2 Glycopro-teoforms Enabled by Expressed Serine Ligation显示文摘Naturally occurring interleukin-2(IL-2)is a pleiotropic glycoprotein that regulates immune responses by controlling the differentia-tion and homeostasis of T cells.Non-glycosylated IL-2 has been used in clinical settings for three decades.However,the function of the O-glycan of native IL-2 remains elusive.Herein,to stress this issue,we report a highly efficient semi-synthesis of homogeneous glycosylated IL-2 with various glycoproteoforms on a multi-milligram scale.The glycopeptide fragment was prepared by chemical synthesis and then merged with recombinant fragment via a serine ligation to generate the desired glycoprotein in a single opera-tion.Biological evaluation of the homogenous glycoprotein library reveals that the activity of IL-2 in activating individual T cell subset is glycan dependent,thus highlighting the possibility of further improving current clinical medicine. | Jie Zhao Jiazhi Liu Xinnan Liu Qi Cao Hongbo Zhao Lizhen Liu Farong Ye Can Wang Hong Shao Dongxiang Xue Houchao Tao Bin Li Biao Yu Ping Wang | 2022 | Chinese Journal of Chemistry2022，40，7： | 1 |
| 10 | Protective effects of the polysaccharide from Euphorbia Kansui (Euphorbiaceae)on the swimming exercise-induced oxidative stress in mice显示文摘 | Farong Yu Shunqing Lv Fahong Yu | 2006 | Can J Physiol Pharmacoi2006，84，： | 1 |
| 11 | Preparation and properties of silicon-containing arylacetylene resin/benzox- azines blends 显示文摘 | Gao Yu Zhou Yah Huang Farong | 2013 | High Performance Polymers2013，25，4： | 1 |
| 12 | Synthesis and characterization of a novel acetylene‐ and maleimide‐terminated benzoxazine and its high‐performance thermosets显示文摘 | Yu Gao Farong Huang Yan Zhou Lei Du | 2012 | J. Appl. Polym. Sci2012，，1： | 1 |
| 13 | Research and development on the China low activation martensitic (CLAM) steel显示文摘 | HUANG Qunying WAN Farong | 2007 | J Nucl Mater2007，，： | 1 |
| 14 | Protective effects of the polysaccharide from Euphorbia Kansui (Euphorbiaceae)on the swimming exercise-induced oxidative stress in mice 显示文摘 | Farong Yu Shunqing Lv Fahong Yu | 2006 | Can J Physiol Phannacoi2006，84，： | 1 |
| 15 | Research and development on the China low acti ration martensitic steel (CLAM)显示文摘 | YU Jinnan HUANG Qunying WAN Farong | 2007 | J Nucl Ma ter2007，367，： | 1 |
| 16 | Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and function显示文摘Vaccines have been the primary remedy in the global fight against coronavirus disease 2019(COVID-19).The receptor-binding domain(RBD)of the spike protein,a critical viral immunogen,is affected by the heterogeneity of its glycan structures and relatively low immunogenicity.Here,we describe a scalable synthetic platform that enables the precise synthesis of homogeneously glycosylated RBD,facilitating the elucidation of carbohydrate structure–function relationships.Five homogeneously glycosylated RBDs bearing biantennary glycans were prepared,three of which were conjugated to T-helper epitope(Tpep)from tetanus toxoid to improve their weak immune response.Relative to natural HEK293-derived RBD,synthetic RBDs with biantennary N-glycan elicited a higher level of neutralising antibodies against SARS-CoV-2 in mice.Furthermore,RBDs containing T_(pep)elicited significant immune responses in transgenic mice expressing human angiotensin-converting enzyme 2.Our collective data suggest that trimming the N-glycans and T_(pep)conjugation of RBD could potentially serve as an effective strategy for developing subunit vaccines providing efficient protection. | Farong Ye Cheng Li Feng-Liang Liu Xinliang Liu Peng Xu Rong-Hua Luo Wenping Song Yong-Tang Zheng Tianlei Ying Biao Yu Ping Wang | 2024 | National Science Review2024，11，2： | 0 |
| 17 | Technologies and studies of gas exchange in two-stroke aircraft piston engine:A review显示文摘The in-cylinder gas exchange process is crucial to the power performance of two-stroke aircraft piston engines,which is easily influenced by complex factors such as high-altitude performance variation and in-cylinder flow characteristics.This paper reviews the development history and characteristics of gas exchange types,as well as the current state of theory and the validation methods of gas exchange technology,while also discusses the trends of cutting-edge technologies in the field.This paper provides a theoretical foundation for the optimization and engineering design of gas exchange systems and,more importantly,points out that the innovation of gas exchange types,the modification of theoretical models,and the technology of variable airflow organization are the key future research directions in this field. | Yu ZHOU Xueyu LI Shuiting DING Shuai ZHAO Kun ZHU Longtao SHAO Farong DU Gerui WANG Zheng XU | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
| 18 | Effects of Maca Extract on Endurance and Blood Antioxidant Enzyme Activity of Rats显示文摘[Objectives] The aim was to investigate the effects of maca extract on endurance and blood antioxidative enzyme activity of rats.[Methods]The Wistar rats treated with/without maca extract( 8. 0,16. 0,and 32. 0 g/kg) were given with free access to circulating water.The administration was conducted for 15 consecutive d. On the 16 th d,the endurance and blood malondialdehyde( MDA),superoxide dismutase( SOD) and glutathione peroxidase( GSH-Px) levels of the rats were determined. [Results] Compared with those of the rats without maca extract treatment,the swimming time before sinking of the rats administered with 8. 0,16. 0,and 32. 0 g/kg of maca extract was increased by 34. 38%,84. 25% and 126. 07%( P < 0. 01),the total swimming time was increased by 37. 42%,47. 03% and 107. 24%( P <0. 01),the times of sinking was reduced by 17. 65%,33. 28% and 55. 50%( P < 0. 05,P < 0. 01),the blood MDA level was reduced by 34.63%,54. 13% and 63. 73%( P < 0. 01),the blood SOD activity was increased by 67. 78%,108. 25% and 154. 49%( P < 0. 01),and the blood GSH-Px level was increased by 48. 57%,110. 28% and 154. 86%( P < 0. 01). [Conclusions]Maca extract has the functions of resisting fatigue and enhancing athletic,and the mechanisms are related to the reduction of blood MDA level and the increase of blood SOD and GSH-Px activity. | Zuoping LI Farong YU Mingren XIE | 2018 | Medicinal Plant2018，9，4： | 0 |
| 19 | Effects of Noise Pollution on Functions of the Liver and Kidney of Rats显示文摘To study the effects of noise pollution on the functions of the liver and kidney of rats,a total of 40 male SPF Wistar rats were randomly divided into a control group and three experimental groups. The rats in the experimental groups were respectively stimulated with 38,55 and 70 dB noise for 15 days,and the levels of blood components were determined by an automatic biochemical analyzer. The results showed that in comparison with the control group,the level of the blood glucose in the experimental groups increased by 23. 53%,52. 94% and 88. 24%,respectively,and the differences were statistically significant( P < 0. 01). The levels of triglyceride in the blood rose by 20. 83%,38. 54% and 79. 68%,respectively,and the differences were also statistically significant( P < 0. 01). The level of globulin in the blood increased by 16. 49%,21. 13% and 51. 78%,and the level of albumin in the blood rose by 9. 51%,12. 67% and 17. 89%,respectively. The level of total bilirubin in the blood increased by 27. 04%,41. 63% and 73. 67%,respectively,and the differences were statistically significant( P < 0. 01). The level of creatinine in the blood rose by 9. 72%,10. 21% and 20. 99%,respectively. The level of amylase in the blood reduced by 6. 6%,13. 05% and 23. 89%,respectively. The level of creatine kinase in the blood decreased by 19. 81%,27. 37% and 36. 81%,respectively,and the level of urea in the blood reduced by 11. 19%,12. 77% and19. 26%,respectively. The results revealed that noise pollution could significantly affect the levels of blood components and the functions of the liver and kidney of rats. | Yu Farong Yu Xin Li Zuoping Lian Xiuzhen Xie Mingren Li Denglou | 2018 | Meteorological and Environmental Research2018，9，4： | 0 |
| 20 | Effect of Octadecadienoic Acid on Proliferation and Apoptosis of Glioma Cells and Its Mechanism显示文摘[Objectives] To explore the inhibitory effect of octadecadienoic acid (ODA) on proliferation and apoptosis of glioma cells and its mechanism. [Methods] Cultured human glioma cells (cell density 2×10^(6) cells/L) were divided into three groups: solvent control group (DMSO, 30 μL/L), 5-FU group (10 mg/L) and octadecadienoic acid group (0.3, 0.6, 1.2 mg/L). The toxic effects of ODA on glioma cells were detected by trypan blue and thiazolium blue (MTT). The expression of P53, PI3K, P21, PKB/Akt and caspase-9 protein in glioma cells were detected by enzyme-linked immunosorbent assay (ELISA). [Results] The cell count under optical microscope showed that the inhibition rate of cell proliferation in low, medium and high dose ODA groups and 5-FU group was significantly higher than that in solvent control group ( P <0.01), but there was no significant difference compared with 5-FU group ( P >0.05). The results of MTT showed that compared with the solvent control group, the inhibition rate of cell proliferation in low, medium and high dose ODA groups and 5-FU group significantly increased ( P <0.01);compared with 5-FU group, the inhibition rate of cell proliferation in high dose ODA group significantly increased ( P <0.01). The results of flow cytometry showed that compared with the solvent control group, the number of cells in G_(0)/G_(1) phase increased significantly ( P <0.05, P <0.01), the number of cells in G_(2)/M phase decreased significantly ( P <0.01) and the apoptosis rate increased significantly ( P <0.01) in the low, medium and high dose ODA groups and 5-FU group;compared with 5-FU group, the number of cells in G_(2)/M phase decreased significantly ( P <0.01) and the apoptosis rate increased significantly ( P <0.01) in ODA group. ELISA testing results showed that the expression levels of P53, P13K and PKB/Akt in low, medium and high dose ODA groups and 5-FU group were significantly lower than those in solvent control group ( P <0.01), and only the expression level of protein in high dose ODA group was significantly lower than that in 5-FU group ( P <0.01);the expression levels of P21 and caspase-9 in low, medium and high dose ODA groups and 5-FU group were significantly higher than those in solvent control group ( P <0.05, P <0.01), but the expression level of protein in high dose ODA group was significantly higher than that in 5-FU group ( P <0.01). [Conclusions] ODA can obviously inhibit the proliferation of glioma cells and induce apoptosis. The mechanism is related to up-regulation of P21, caspase-9, down-regulation of P53, PI3K, PKB/Akt, inhibition of cell division cycle and decrease of PI3K-Akt signal transduction pathway. | Mingren XIE Xia YUAN Shan QI Lei YU Farong YU | 2023 | Medicinal Plant2023，14，4： | 0 |
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