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| 1 | Metal nanoparticles induced photocatalysis显示文摘Photocatalysis induced by light absorption of metal nanoparticles(NPs) has emerged as a promising strategy for exploiting efficient visible-light-responsive composites for solar-energy conversion. In this review, we first introduce the light absorption of metal NPs and the mechanisms proposed in metal-induced photocatalysis(MIP). Then, its applications in water splitting, artificial photosynthesis and inert molecular activation are summarized. To address the challenge of low efficiency in this field, strategies in promoting catalytic activity are reviewed, and particular attention is paid to the particle-size effect of metal. Finally, the challenges and possible development directions of MIP are briefly discussed. | Lequan Liu Xinnan Zhang Lufeng Yang Liteng Ren Defa Wang Jinhua Ye | 2017 | National Science Review2017，4，5： | 7 |
| 2 | MG149 inhibits histone acetyltransferase KAT8-mediated IL-33 acetylation to alleviate allergic airway inflammation and airway hyperresponsiveness显示文摘Asthma is one of the most common heterogeneous airway diseases.Worldwide,the prevale nee of doctor-diagnosed asthma in adults was reported to be 4.3%in 2OO3.^(1)In China,the overall prevalence of asthma duri nq 2012 a nd 2015 was 4.2%,represe nting 45.7 million Chinese adults.^(2)Although comprehensive approaches have been used in clinical practice,a considerable number of people are still hospitalized for acute exacerbation of asthma every year.In China,15.5%of asthmatics reported at least one emergency room visit and 7.2%reported at least one hospital admission due to exacerbation of respiratory symptoms.^(2)A need exists to clarify the mechanism of asthma's pathogenesis and to identify more appropriate and precise therapies for asthma. | Yahui Liu Juan Du Xinnan Liu Lingbiao Wang Yichao Han Chunrong Huang Rui Liang Fang Zheng Guochao Shi Bin Li | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 2 |
| 3 | Regulatory effect of traditional Chinese medicines on signaling pathways of process from chronic atrophic gastritis to gastric cancer显示文摘Chronic atrophic gastritis(CAG),a common disease of digestive system,is an extremely important cause of gastric cancer(GC).The occurrence and development of CAG involves the abnormality of multiple signaling pathways.Traditional Chinese medicines(TCMs)has the advantages of mild action,multi-target and small adverse reaction,etc.,which broadens the way for the treatment of the disease,and TCMs can play a therapeutic role by regulating multiple signaling pathways.In this review,based on the related experiments of TCMs and Chinese herbal compounds in recent years,the related literatures were searched and 10 kinds of signaling pathways involved were summarized,in order to provide a reference for further research on reversing or delaying the progress of CAG and preventing gastric cancer. | Xinnan Liu Shuping Wang Jingyang Li Jingze Zhang Dailin Liu | 2022 | Chinese Herbal Medicines2022，14，1： | 2 |
| 4 | Revealing Functional Significance of Interleukin-2 Glycopro-teoforms Enabled by Expressed Serine Ligation显示文摘Naturally occurring interleukin-2(IL-2)is a pleiotropic glycoprotein that regulates immune responses by controlling the differentia-tion and homeostasis of T cells.Non-glycosylated IL-2 has been used in clinical settings for three decades.However,the function of the O-glycan of native IL-2 remains elusive.Herein,to stress this issue,we report a highly efficient semi-synthesis of homogeneous glycosylated IL-2 with various glycoproteoforms on a multi-milligram scale.The glycopeptide fragment was prepared by chemical synthesis and then merged with recombinant fragment via a serine ligation to generate the desired glycoprotein in a single opera-tion.Biological evaluation of the homogenous glycoprotein library reveals that the activity of IL-2 in activating individual T cell subset is glycan dependent,thus highlighting the possibility of further improving current clinical medicine. | Jie Zhao Jiazhi Liu Xinnan Liu Qi Cao Hongbo Zhao Lizhen Liu Farong Ye Can Wang Hong Shao Dongxiang Xue Houchao Tao Bin Li Biao Yu Ping Wang | 2022 | Chinese Journal of Chemistry2022，40，7： | 1 |
| 5 | A new method to prepare calcium oxalate films for marble protection显示文摘Artificial calcium oxalate films have been applied to protect sculptures,monuments,and buildings made of marble due to their potential protective capacities.Unfortunately,artificially prepared calcium oxalate films are usually loose,and easy to peel off in contrast to the natural ones.In this paper,a new method was developed for the preparation of a compact and cohesive calcium oxalate film,using ethylene glycol as an additive.The morphology,elemental composition,structure,and crystal phase of the film were analyzed by SEM,EDX,IR,and XRD,and the protective effects were investigated by acid resistance test,while its adhesion to the underlying marble by the Scotch tape test.The porosity,water absorption,and color of treated marble were also assessed.The results showed that a calcium oxalate film with a compact structure,good adhesion,and a protective effect against acid rain can be successfully obtained by including ethylene glycol as an additive.With the new preparation method,a better bond between the stone and the film is obtained which contributes to solving the spalling problem of the artificial calcium oxalate films. | HE Lu JIANG YiJie MA WenTing LIU Yan YANG FuWei LU RuiCong WANG Lu ZHANG Kun CHEN XinNan GAO Xiang | 2023 | Science China(Technological Sciences)2023，66，8： | 0 |
| 6 | Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center显示文摘oluntary contribution has become the only source of donor lungs in China since 2015.To elaborate the outcomes of patients awaiting lung transplantation(LTx)after the implementation of donation after brain death,we performed a retrospective study that encompassed 205 patients with end-stage lung disease who registered for LTx at Shanghai Pulmonary Hospital from January 1,2015 to January 1,2021.A total of 180 patients were enrolled in the study.The median waiting time was 1.25 months.Interstitial lung disease(ILD)(103/180,57.2%)and chronic obstructive pulmonary disease(COPD)(56/180,31.1%)were the most common diseases in our study population.The mean pulmonary artery pressure(mPAP)of patients in the died-waiting group was higher than that of the survivors(53.29+21.71 mmHg vs.42.11+18.58 mmHg,P-0.002).The mortality of patients with ILD(34/103,33.00%)was nearly twice that of patients with COPD(10/56,17.86%)while awaiting LTx(P-0.041).In the died-waiting group,patients with ILD had a shorter median waiting time than patients with COPD after being listed(0.865 months vs.4.720 months,P-0.030).ILD as primary disease and mPAP>35 mmHg were two significant independent risk factors for waitlist mortality,with hazard ratios(HR)of 3.483(95%CI 1.311-9.111;P-0.011)and 3.500(95%CI 1.435-8.536;P=0.006).Hence,LTx is more urgently needed in patients with ILD and pulmonary hypertension. | Yuling Yang Xinnan Xu Ming Liu Yanfeng Zhao Yongmei Yu Xiaogang Liu Chang Chen Gening Jiang Wenxin He | 2022 | Frontiers of Medicine2022，16，5： | 0 |
| 7 | Chemical constituents and pharmacological activities of medicinal plants from Rosa genus显示文摘The genus Rosa(Rosaceae family)includes about 200 species spread in the world,and this genus shows unique advantages in medicine and food.To date,several scholars concentrated on compounds belonging to flavonoids,triterpenes,tannins,polysaccharide,phenolic acids,fatty acids,organic acids,carotenoids,and vitamins.Pharmacological effects such as antineoplastic and anti-cancer properties,antiinflammatory,antioxidant,liver protection,regulate blood sugar,antimicrobial activity,antiviral activity,as well as nervous system protection and cardiovascular protection were wildly reported.This article reviews the chemical constituents,pharmacological effects,applications and safety evaluations of Rosa plants,which provides a reference for the comprehensive utilization of medicine and food resources and gives a scientific basis for the development of medicinal plants of the genus Rosa. | Yansheng Wang Yanmin Zhao Xinnan Liu Jingyang Li Jingze Zhang Dailin Liu | 2022 | Chinese Herbal Medicines2022，14，2： | 0 |
| 8 | Study on Dormancy Mechanism and Dormancy-breaking Method of Velvetleaf(Abutilon theophrasti)Seeds显示文摘[Objectives]This study was conducted to explore how can we better break the dormancy of velvetleaf seeds and the best method to promote seed germination.[Methods]With the seeds of velvetleaf(Abutilon theophrasti)as experimental materials,the dormancy of velvetleaf seeds was revealed through seed vigor determination,water absorption rate determination and germination tests,and the seeds of velvetleaf were treated by physical and chemical methods to explore the best method for breaking dormancy of velvetleaf seeds.[Results]Poor water permeability of seed coat and endogenous inhibitory substances present in the seeds were the main reasons leading to the dormancy of velvetleaf seeds.The shell-breaking treatment,98%concentrated sulfuric acid treatment and 40%NaOH strong alkali treatment all could break the dormancy obstacle of velvetleaf seed coat.Compositing the above measures with 200 mg/ml gibberellin solution could further improve the germination ability of seeds.Among them,compositing the mechanical shell-breaking treatment with gibberellin had the best effect,followed by the composite of 10 and 15 min of 98%concentrated sulfuric acid treatment with gibberellin.[Conclusions]This study lays a foundation for the utilization and development and the comprehensive prevention and control research of velvetleaf seeds. | Kuojie XIAO Chenzhong JIN Yunyun ZHOU Jun PAN Shunli XIAO Kaifa GUO Xinnan QING Xiu LIU | 2020 | Agricultural Biotechnology2020，9，5： | 0 |
| 9 | A partition approach for robust gait recognition based on gait template fusion显示文摘Gait recognition has significant potential for remote human identification,hut it is easily influenced by identity-unrelated factors such as clothing,carrying conditions,and view angles.Many gait templates have been presented that can effectively represent gait features.Each gait template has its advantages and can represent different prominent information.In this paper,gait template fusion is proposed to improve the classical representative gait template(such as a gait energy image)which represents incomplete information that is sensitive to changes in contour.We also present a partition method to reflect the different gait habits of different body parts of each pedestrian.The fused template is cropped into three parts(head,trunk,and leg regions)depending on the human body,and the three parts are then sent into the convolutional neural network to learn merged features.We present an extensive empirical evaluation of the CASIA-B dataset and compare the proposed method with existing ones.The results show good accuracy and robustness of the proposed method for gait recognition. | Kejun WANG Liangliang LIU Xinnan DING Kaiqiang YU Gang HU | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，5： | 0 |
| 10 | Mechanical properties of(B_(4)C+Al_(2)O_(3))/Al neutron absorbing materials with various microstructures constructed by hot forging,rolling and extrusion显示文摘Neutron absorbing materials(NAMs)are necessary in the nuclear industry for the storage and transportation of spent fuel.Among all the NAMs,B_(4)C/Al composites are widely used because of the specific neutron absorption capacity[1–4].Compared with traditional low-strength functional NAMs such as B_(4)C/1100Al and B_(4)C/6061Al,NAMs with enough high-temperature(350℃)strength are competent for further structural usage and exhibit huge advantages in the dry storage of spent fuel because of heat transfer ability and weight reduction[5]. | ZAN YuNing LI XinNan ZHOU Cong LIU ZhenYu WANG QuanZhao XIAO BoLü MA ZongYi | 2022 | Science China(Technological Sciences)2022，65，5： | 0 |
| 11 | Structural diversification of bioactive bibenzyls through modular co-culture leading to the discovery of a novel neuroprotective agent显示文摘Bibenzyls,a kind of important plant polyphenols,have attracted growing attention for their broad and remarkable pharmacological activities.However,due to the low abundance in nature,uncontrollable and environmentally unfriendly chemical synthesis processes,these compounds are not readily accessible.Herein,one high-yield bibenzyl backbone-producing Escherichia coli strain was constructed by using a highly active and substrate-promiscuous bibenzyl synthase identified from Dendrobium officinale in combination with starter and extender biosynthetic enzymes.Three types of efficiently postmodifying modular strains were engineered by employing methyltransferases,prenyltransferase,and glycosyltransferase with high activity and substrate tolerance together with their corresponding donor biosynthetic modules.Structurally different bibenzyl derivatives were tandemly and/or divergently synthesized by co-culture engineering in various combination modes.Especially,a prenylated bibenzyl derivative(12)was found to be an antioxidant that exhibited potent neuroprotective activity in the cellular and rat models of ischemia stroke.RNA-seq,quantitative RT-PCR,and Western-blot analysis demonstrated that 12 could up-regulate the expression level of an apoptosis-inducing factor,mitochondria associated 3(Aifm3),suggesting that Aifm3 might be a new target in ischemic stroke therapy.This study provides a flexible plug-and-play strategy for the easy-to-implement synthesis of structurally diverse bibenzyls through a modular co-culture engineering pipeline for drug discovery. | Yuyu Liu Xinnan Li Songyang Sui Jingshu Tang Dawei Chen Yuying Kang Kebo Xie Jimei Liu Jiaqi Lan Lei Wu Ridao Chen Ying Peng Jungui Dai | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
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