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| 1 | Production and activity of matrix metalloproteinases during liver fibrosis progression of chronic hepatitis C patients显示文摘BACKGROUND Matrix metalloproteinases(MMPs)participate in the degradation of extracellular matrix compounds,maintaining the homeostasis between fibrogenesis and fibrolytic processes in the liver.However,there are few studies on the regulation of liver MMPs in fibrosis progression in humans.AIM To assess the production activity and regulation of matrix metalloproteinases in liver fibrosis stages in chronic hepatitis C(CHC).METHODS A prospective,cross-sectional,multicenter study was conducted.CHC patients were categorized in fibrosis grades through FibroTest®and/or FibroScan®.Serum MMP-2,-7,and-9 were determined by western blot and multiplex suspension array assays.Differences were validated by the Kruskal-Wallis and Mann-Whitney U tests.The Spearman correlation coefficient and area under the receiver operating characteristic curve were calculated.Collagenolytic and gelatinase activity was determined through the Azocoll substrate and zymogram test,whereas tissue inhibitor of metalloproteinase-1 production was determined by dot blot assays.RESULTS Serum concentrations of the MMPs evaluated were higher in CHC patients than in healthy subjects.MMP-7 distinguished early and advanced stages,with a correlation of 0.32(P<0.001),and the area under the receiver operating characteristic displayed moderate sensitivity and specificity for MMP-7 in F4(area under the receiver operating characteristic,0.705;95%confidence interval:0.605-0.805;P<0.001).Collagenolytic activity was detected at F0 and F1,whereas gelatinase activity was not detected at any fibrosis stage.Tissue inhibitor of metalloproteinase-1 determination showed upregulation in F0 and F1 but downregulation in F2(P<0.001).CONCLUSION High concentrations of inactive MMPs were present in the serum of CHC patients,reflecting the impossibility to restrain liver fibrosis progression.MMPs could be good diagnostic candidates and therapeutic targets for improving novel strategies to reverse liver fibrosis in CHC. | Moises Martinez-Castillo Abigail Hernandez-Barragan Ivonne Flores-Vasconcelos Marina Galicia-Moreno Dorothy Rosique-Oramas Jose Luis Perez-Hernandez Fatima Higuera-De la Tijera Eduardo E Montalvo-Jave Aldo Torre-Delgadillo Paula Cordero-Perez Linda Muñoz-Espinosa David Kershenobich Gabriela Gutierrez-Reyes | 2021 | World Journal of Hepatology2021，13，2： | 2 |
| 2 | Extracellular invertase is an essential component of cytokinnin-mediated delay of senescence显示文摘 | LARA M E B GARCIA M C G FATIMA T | 2004 | The Plant Ce112004，16，： | 1 |
| 3 | Ultra performance liquid chromatography tandem mass spectrometry performance evaluation for analysis of antibiotics in natural waters显示文摘 | FATIMA T FABIEN M JOELLE E | 2009 | Anal Bioanal Chem2009，393，67： | 1 |
| 4 | Serrated polyps of the colon: how reproducible is their classification?显示文摘 | Arzu Ensari Banu Bilezik?i Fatima Carneiro Gülen Bülbül Do?usoy Ann Driessen Ay?e Dursun Jean-Fran?ois Flejou Karel Geboes Gert de Hertogh Anne Jouret-Mourin Cord Langner Ir?s D. Nagtegaal Johan Offerhaus Janina Orlowska Ari Ristim?ki Julian Sanz-Ortega B | 2012 | Virchows Archiv2012，，5： | 1 |
| 5 | Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: Effects on the oxidative stress 显示文摘 | JIHEN E H IMED M FATIMA H | 2009 | Ecotoxicology and Environmental Safety2009，72，： | 1 |
| 6 | More stable struc- ture of wheat germ lipase at low pH than its native state 显示文摘 | Ahmad E Fatima S Khan M | 2010 | Biochimie2010，92，7： | 1 |
| 7 | Low molecular weight heparin loaded pH-sensitive microparticles 显示文摘 | YVETTE M NATHALIE U FATIMA E G | 2007 | Int J Pharm2007，335，12： | 1 |
| 8 | Characterization and effect of edible coatings on minimally processed garlic quality显示文摘 | MAIA E R FATIMA F S N ALVARENGA B D | 2008 | Carbohydrate Polymers2008，72，3： | 1 |
| 9 | Protective effectsof selenium ( Se) and zinc (Zn) on cadmium ( Cd) toxici-ty in the liver of the rat : effects on the oxidative stress显示文摘 | JIHEN E IMED M FATIMA H | 2009 | Ecotoxicology and Environmental Safety2009，72，5： | 1 |
| 10 | Homogenization of a reaction-diffusion system modeling sulfate corrosion of concrete in locally periodic perforated domains显示文摘 | Fatima T Arab N Zemskov E P | 2011 | Journal of Engineering Mathematics2011，69，2： | 1 |
| 11 | IS30 elements are mediators of genetic diversity in Oenococcus oeni显示文摘 | FATIMA E G MARGUERITE D L ELISABETH B | 2012 | International Journal of Food Microbiology2012，158，1： | 1 |
| 12 | Extracellular invertase is an essential component of cytokinin-mediated delay of senescence显示文摘 | BALIBREA LARA M E GONZALEZ GARCIA M C FATIMA T EHNESS R LEE T K PROELS R TANNER W ROITSCH T | 2004 | Plant Cell2004，16，： | 1 |
| 13 | Nonlinear total variation based noise removal algorithms显示文摘 | Rudin L I 0sher S Fatima E | 1992 | Physica D1992，60，1： | 1 |
| 14 | Fatigue life prediction of an asphalt pavement subjected to multiple axle loadings with viscoelastic FEM 显示文摘 | ZOA A FATIMA A CHRISTOPHE P ROBRET M E | 2013 | Construction and Building Materials2013，43，6： | 1 |
| 15 | Extracellular invertase is an essential component of cytokinin-mediated delay of senescence显示文摘 | Lara M E B Garcia M C G Fatima T | 2004 | Plant Cell2004，16，： | 1 |
| 16 | Carbonization of coals in the presence of alkaline hydroxides and carbonates: formation of activated carbons 显示文摘 | PIERRE E ABDELHAMID A FATIMA A | 1986 | Fuel1986，65，10： | 1 |
| 17 | Extracellular invertase is an essential component of cytokin in-mediated delay of senescence 显示文摘 | Balibrea Lara M E Gonzdlez Garcia M C Fatima T | 2004 | Planl Cell2004，16，5： | 1 |
| 18 | Plasma beads loaded with Candida 'albieans cytosolie proteins impart protection against the fungal infection in BALB/e mice显示文摘 | Ahmad E Fatima M T Saleemuddin M | 2012 | Vaccine2012，12，： | 1 |
| 19 | Asymmetric reduction of prochiral ketones using in situ generated oxazaborolidine derived from (1S,2S, 3R, 4R)-3-amino-7, 7-dimethoxynorbornan-2-ol: an efficient synthesis of enantiopure (R)-tomoxetine 显示文摘 | Lapis A A M Fatima A Martins J E D | 2005 | Tetrahedron Letters2005，46，3： | 1 |
| 20 | Examination of single and multiple mutations involved in resistance to quinolones in Staphylococcus aureus by a combination of PCR and denaturing high-performance liquid chromatography(DHPLC)显示文摘 | M'ZALI F H FATIMA A JANE E | 2002 | Antimicrob Agents Chemother2002，50，5： | 1 |
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