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| 1 | Starting glargine in insulin-nave type 2 diabetic patients based on body mass index is safe显示文摘AIM:To evaluate the safety of four insulin titration algorithms in a homogeneous population of insulin-na ve type 2 diabetic patients.METHODS:We conducted a 24-wk,open,single-center study with 92 insulin-na ve type 2 diabetes patients who failed treatment with one or two oral drugs.The patients were randomized to one of the four following algorithms:LANMET(n=26)and LANMET PLUS(n=22)algorithms,whose patients received a fixed initial insulin dose of 10 U,and DeGold(n=23)and DeGold PLUS(n=21)algorithms,whose patients’initial insulin dose was based on their body mass index(BMI).In addition,patients in the PLUS groups had their insulin titrated twice a week from 2 to 8 U.In the other two groups,the titration was also performed also twice a week,but in a fixed increments of 2 U.The target fasting glucose levels for both groups was 100 mg/dL.RESULTS:There was no significant difference in efficacy parameters.There was no significant difference when comparing moderate hypoglycemia events in algorithms starting with a 10 U fixed dose and algorithms based on BMI.However,there was a significant increase in moderate hypoglycemia events among the PLUS treated patients when the LANMET and DeGold algorithms were compared with the 2 fast-titration PLUS algorithms.We observed 12 hypoglycemia events in the first group,which corresponded to 0.94 events/patient per year,and we observed 42 events in the second group,which corresponded to 2.81 events/patient per year(P<0.037).No further significant differences were observed when other comparisons between the algorithms were carried out.CONCLUSION:Starting insulin glargine based on BMI is safe,but fast titration algorithms increase the risk of moderate hypoglycemia. | Denise R Franco Juliana Baptista Fatima RM Abreu Risoneide B Batista Freddy G Eliaschewitz | 2014 | World Journal of Diabetes2014，5，1： | 2 |
| 2 | Supercritical fluid extraction for pesticide multiresidue analysis in honey: determination by gas chromatography with electron-capture and mass spectrometry detection 显示文摘 | Sandra R R Mario S G Fatima R N K | 2004 | Journal of Chromatography A2004，1048，： | 1 |
| 3 | Effect of removing seminal plasma using a sperm filter on the viability of refrigerated stallion semen 显示文摘 | Neto C R Monteiro G A Fatima R S et d | 2013 | J Equine Vet Sci2013，33，： | 1 |
| 4 | Early gastric cancer in your,asymptomatic carriers of germ-line E-cadherin mutations显示文摘 | Carnairo Fatima Lewis Frank R | 2001 | N Engl J Med2001，344，： | 1 |
| 5 | A powerful methodological approach combining headspace solid phase micro- extraction,mass spectrometry and muhivariate analysis for profiling the volatile metabolomic pattern of beer starting raw materials 显示文摘 | Joeo L G Jos6 A F Fatima P R | 2014 | Food Chemistry2014，160，1： | 1 |
| 6 | Nutrient balance of shifting cultivation by burning or mulching in the Eastern Amazon evidence for subsoil nutrient accumulation显示文摘 | SOMMER R VLEK P L G DE ABREU SA TD VIELHAUER K DE FATIMA RODRIGUES COELHO R FOLSTER H | 2004 | Nutrient Cy- cling in Agroecosystems2004，68，： | 1 |
| 7 | Identification of anthocyanin pigments in strawberry (cv Camarosa) by LC using DAD and ESI-MS detection显示文摘 | FATIMA L S SONIA P T JULIAN R G | 2002 | Eur Food Res Technol2002，214，： | 1 |
| 8 | Expression of proinflammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis显示文摘 | CLAUDIO R R FATIMA G FERNANDO D | 2001 | DigDis Sci2001，46，8： | 1 |
| 9 | Expression of proinflammatory cytokines and the inhibitors during the course of spontaneous bacterial peritonitis 显示文摘 | Claudior R Fatima G Fernando D | 2001 | Dig Dis Sci2001，46，8： | 1 |
| 10 | Cgtogenetic characfetic charactetization of Lippia and Lantana camara(Verbenaceac)form Brazil显示文摘 | Lyddrson L V Fatima R G | 2007 | J Plants Res2007，120，： | 1 |
| 11 | Expression of proinflammatory cy-tokines and their inhibitors during the course of spontaneous bacterial perito -nitis显示文摘 | Claudio R R Fatima G Fernando D | 2001 | Dig Dis Sci2001，，8： | 1 |
| 12 | Expression of prolnftammatory cytokines and their inhibitors during the course of spontaneous bacterial peritonitis 显示文摘 | Claudio R R Fatima G Fernando D | 2001 | Dig Dis Sci2001，46，8： | 1 |
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