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| 1 | Urogenital schistosomiasis and soiltransmitted helminthiasis(STH)in Cameroon:An epidemiological update at Barombi Mbo and Barombi Kotto crater lakes assessing prospects for intensified control interventions显示文摘Background:The crater lakes of Barombi Mbo and Barombi Kotto are well-known transmission foci of schistosomiasis and soil-transmitted helminthiasis having had several important control initiatives previously.To collect contemporary epidemiological information,a cross-sectional survey was undertaken inclusive of:signs and symptoms of disease,individual treatment histories,local water,sanitation and hygiene(WASH)-related factors and malacological surveillance,with molecular characterisation of specimens.Methods:At each lake,a community cross-sectional survey was undertaken using a combination of stool and urine parasitological sampling,and interview with pro-forma questionnaires.A total of 338 children and adults participated.Material from snail and parasite species were characterised by DNA methods.Results:Egg-patent prevalence of urogenital schistosomiasis was 8.7%at Barombi Mbo(all light-intensity infections)and 40.1%at Barombi Kotto(21.2%heavy-intensity infections).Intestinal schistosomiasis was absent.At Barombi Kotto,significantly more women reported signs and symptoms associated with female genital schistosomiasis.While there had been extensive recent improvement in WASH-related infrastructure at Barombi Mbo,water contact risk scores were higher among schistosomiasis-infected participants(P<0.001)and at Barombi Kotto in general(P<0.001).Across both lakes,mean prevalence of STH was very low(6.3%)evidencing an impressive decrease of 79.0%over the last decade;neither Strongyloides stercoralis nor Ascaris lumbricoides were found.A total of 29 freshwater sampling sites were inspected for snails,13 in Barombi Mbo and 16 in Barombi Kotto;water chemistry differed significantly(P<0.0001)between lakes for both mean pH(7.9 v.9.6)and mean conductivity(64.3μS v.202.1μS)respectively.Only two Bulinus camerunensis found on the central island of Barombi Kotto were observed to shed schistosome cercariae,but schistosome DNA was later detected in Bulinus sampled from both lakes as well as in Indoplanorbis exustus,an invasive species from Asia.Conclusions:STH is currently at very low levels while urogenital schistosomiasis is of greatest concern at Barombi Kotto.This assessment highlights a unique opportunity for further study of the epidemiological dynamics at these crater lakes,to evaluate future intensified interventions both in terms of gaining and sustaining control at Barombi Kotto or in moving towards local interruption of transmission of both diseases at Barombi Mbo. | Suzy J.Campbell J.Russell Stothard Faye O’Halloran Deborah Sankey Timothy Durant Dieudonne Eloundou Ombede Gwladys Djomkam Chuinteu Bonnie LWebster Lucas Cunningham EJames LaCourse Louis-Albert Tchuem-Tchuente | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | One-step RT- PCR for detection of Zika virus 显示文摘 | FAYE O FAYE O DUPRESSOIR A | 2008 | J Clin Virol2008，43，1： | 1 |
| 3 | Hemolin gene silencing by ds-RNA injected into Cecropia pupae is lethal to next generation embryos显示文摘 | BETTENCOURT R TERENIUS O FAYE I | | 0，，3： | 1 |
| 4 | Quantitative real-time PCR detection of Zika virus and evaluation with field-caught mosquitoes 显示文摘 | FAYE O FAYE O DIALLO D | 2013 | Virol J2013，10，16： | 1 |
| 5 | Carbon lack ofcorrelation between hydrogen peroxide production and ni-tric oxide production by cultured rabbit articular chondro-cytes treated with fluoroqui-nolone antimicrobial agents显示文摘 | HAYEM G DOMARLE O FAY M | 1996 | Toxicology in Vitro1996，10，5： | 1 |
| 6 | Entomologic investigations of a chikungunya virus epidemic in the Union of the Comoros, 2005 显示文摘 | Sang RC Ahmed O Faye O | 2008 | Am J Trop Med Hyg2008，78，1： | 1 |
| 7 | A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties显示文摘 | Olsen D B Eldrup AB Bartholomew L Bhat B Bosserman M R Ceccacci A Colwell L F Fay J F Flores O A Getty K L Grobler J A LaFemina R L Markel E J Migliaccio G Prhavc M Stahlhut M W Tomassini J E MacCoss M Hazuda D J Carroll S S | | 0，，10： | 1 |
| 8 | Stable epigenetic effects impact adaptation in allopolyploid Orchids (Dac- tylorhiza: Orchidaceae ) 显示文摘 | Paun O Bateman R M Fay M F | 2010 | Mol Biol Evol2010，27，11： | 1 |
| 9 | Hemolin gene si- lencing by ds-RNA injected into Cecropia pupae is lethal to next generation embryos显示文摘 | BETTENCOURT R TERENIUS O FAYE I | 2002 | Insect Molecular Biology2002，11，3： | 1 |
| 10 | Evaluating particle counters显示文摘 | O'Shaughnessy P T Barsotti M G Fay J W | 1997 | Journal American Water Works Association1997，89，12： | 1 |
| 11 | Immunobead-based detection and characterization of circulating tumor cells in melanoma patients显示文摘 | FODSTAD O FAYE R HOIFODT H K | 2001 | Recent Results Cancer Res2001，158，： | 1 |
| 12 | Improved LNA probebased assay for the detection of African and South American yellow fever virus strains显示文摘 | Weidmann M Faye O Faye O | | 0，，3： | 1 |
| 13 | Molecular evolution of Zi- ka virus during its emergence in the 20 (th) century 显示文摘 | Faye O Freire CC Iamarino A | 2014 | PLoS Negl Trap Dis2014，8，1： | 1 |
| 14 | Hepatitis A booster vaccination:is there a need显示文摘 | Van Damme P Banatvala J Fay O | 2003 | Lancet2003，362，9389： | 1 |
| 15 | Specific recognition by insect hemolin显示文摘 | Schmidt O Faye I Lindstroè m Dinetm I | 1993 | Comp Dev immunol1993，，17： | 1 |
| 16 | Regulation of factor Ⅷa by human activated protein C and protein S:inactivation of cofactor in the intrinsic factor Xase显示文摘 | O'Brien LM Masteri M and Fay PJ | 2000 | Blood2000，95，： | 1 |
| 17 | Determination of Taurine Metabolism by Measurement of 15N-enriched Taurine in Cat Urine by Gas Chromatography-mass Spectrometry 显示文摘 | STAMPFLI A A BALLEVRE O FAY L B | 1993 | J Chromatogr1993，617，： | 1 |
| 18 | One-step RT-PCR for detection of Zika virus显示文摘 | Faye O Faye O Dupressoir A | 2008 | Journal of Clinical Virolo- gy2008，43，1： | 1 |
| 19 | 16S rRNA gene-based ident ification of midgut bacteria from field-caught Anopheles gambiae sensu lato and A funestusmosquitoes reveals new species related to known insect symbionts显示文摘 | Lindh J M Terenius O Faye I | | 0，，11： | 1 |
| 20 | Molecular and genetic characterization of propioniein F, a bacteriocin from Propionibacterium freudenreichii 显示文摘 | BREDE D A FAYE T JOHNSBORG O | 2004 | Appl Environ Microbiol2004，70，12： | 1 |
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