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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Assessment of paramedian thalamic infarcts:MR imaging,clinical features and prognosis显示文摘 | Weidauer S Nichtweiss M Zanella FE | 2004 | Eur Radiol2004，14，9： | 1 |
| 3 | Clear cell sarcoma of the ileum: report of a case and review of the literature 显示文摘 | D'Amico FE Ruffolo C Romeo S | 2012 | Int J Surg Pathol2012，20，4： | 1 |
| 4 | Splenectomy for immune thrombocytopenic purpura: Long term results and treatment of postsplenectomy relapses 显示文摘 | Kumar S Diehn FE Gertz MA | 2009 | Ann Hematol2009，81，2： | 1 |
| 5 | The risk of thromboembolism and need for oral anticoagulation after successful atrial fibrillation ablation显示文摘 | Themistoclakis S Corrado A Marchlinski FE | | Journal of the American College of Cardiology0，，： | 1 |
| 6 | Disease persistence in patients with cervical intraepithelial neoplasia undergoing electrosurgical conization显示文摘 | Costa S Nuzzo MD Infante FE | 2002 | Gynecologic Oncology2002，85，1： | 1 |
| 7 | Compensatory frontoparietal ac- tivity during working memory: An endophenotype of obses- sive-compulsive disorder显示文摘 | Vries FE Wit S J Cath DC | 2014 | Biol Psychiat2014，76，11： | 1 |
| 8 | Serum concentrations of β - carotene, vitamins C and E, zinc and selenimn are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population显示文摘 | Galan P Viteri FE Bertrais S | 2005 | Eur J Clin Nutr2005，59，： | 1 |
| 9 | The ecological importance of the Staphylococcus sciuri species group as a reservoir for resistance and virulence genes显示文摘 | Nemeghaire S Argudín MA Feβler AT | 2014 | Vet M icrobiol2014，171，34： | 1 |
| 10 | The Oxa2 protein of Neurospora crassa plays a critical role in the biogenesis of cytochrome oxidase and defines a ubiquitous subbranch of the Oxal/YidC/Alb3 protein family显示文摘 | Funes S Nargang FE Neupert W | 2004 | Molecular Biology of the Cell2004，15，4： | 1 |
| 11 | New genetic associa- tions detected in a host response study to hepatitis B vac- cine显示文摘 | Davila S Froeling FE Tan A | 2010 | Genes Immun2010，11，3： | 1 |
| 12 | Chronic kidney dis- ease: effects on the cardiovascular system 显示文摘 | Echiffrin S Mark L Johannes FE M | 2007 | Circu lation2007，116，1： | 1 |
| 13 | Splerectomy for immuune thmmbocytopenic purpura:Iong-term results and treatmgat for postsphcnectomy relapses显示文摘 | Kumar S Diehn FE Gertz MA | 2002 | Ann Hceatol2002，81，： | 1 |
| 14 | Protective effects of recombinant human granulocyte colony stimulating factor in a rat model of necrotizing enterocolitis显示文摘 | Canpolat FE Yurdakok M Ozsoy S | 2006 | Podiatr Surg Int2006，22，9： | 1 |
| 15 | BCR-ABL kinase domain mutation analysis in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors:recommendations from an expert panel on behalf of European Leukemia Net显示文摘 | Soverini S Hochhaus A Nicolini FE | 2011 | {H}Blood2011，，05： | 1 |
| 16 | Influence of corn hybrids on nitrogen uptake and utilization efficiency 显示文摘 | Scheper J S Below FE | 1987 | American Seed Trade Assoc1987，42，： | 1 |
| 17 | Assessment of paramedian thalamic infarcts :MR imaging, clinical features and prognosis显示文摘 | Weidauer S Nichtweiss M Zanella FE | 2004 | Eur Radiol2004，14，9： | 1 |
| 18 | Cardiac Conduction abnormalities in mice lacking the gap junction protein connexin40显示文摘 | Verheule S van-Batenburg CA Coenjaerts FE | 1999 | J Cardiovasc Electrophysiol1999，10，10： | 1 |
| 19 | The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS显示文摘 | Lehnardt S Lachance C Patrizi S Follett PL Jensen FE Rosenherg DA | 2002 | J Neurosci2002，22，7： | 1 |
| 20 | Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway显示文摘 | Lehnardt S Massillou L Follett P Jensen FE Ratan R Rosenberg DA | 2003 | Proc Natl Acad Sci USA2003，100，14： | 1 |
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