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| 1 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 2 | The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life显示文摘 | Stefano Romeo Federica Sentinelli Valentina M Cambuli Michela Incani Tiziana Congiu Vanessa Matta Sabrina Pilia Isabel Huang-Doran Efisio Cossu Sandro Loche Marco G Baroni | 2010 | Journal of Hepatology2010，，2： | 1 |
| 3 | Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss显示文摘 | Giuliana F Elil M Federica Z | | 0，，11： | 1 |
| 4 | Clinical and bio- logical features of mulitple myelonma involving the gastrointes- inal system显示文摘 | Giampaolo T Federica C M aurizio Z | | Haematolagica0，9，1： | 1 |
| 5 | Endovascular treatment of carotid artery stenosis: evidences from randomized controlled trials and actual indications显示文摘 | Federica I Fabio M Giuseppe G | 2011 | Monaldi archives for chest disease2011，76，4： | 1 |
| 6 | Identification of chlorogenic acid as a resistance factor for thrips in chrysanthemum 显示文摘 | KIRSTEN A L FEDERICA M YOUNG H C et a l | 2009 | Plant Physiology2009，150，3： | 1 |
| 7 | The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life显示文摘 | Stefano Romeo Federica Sentinelli Valentina M Cambuli Michela Incani Tiziana Congiu Vanessa Matta Sabrina Pilia Isabel Huang-Doran Efisio Cossu Sandro Loche Marco G Baroni | 2010 | Journal of Hepatology2010，，2： | 1 |
| 8 | Leukaemia inhibitory factor enhances sheep fertilization in vitro via an influence on the oocyte显示文摘 | Federica L Kazutsugu M | 2006 | Theriogenology2006，，6： | 1 |
| 9 | Adenosine Deaminase Genetic Polymorphism and Coronary Artery Disease 显示文摘 | Banci M Saccucci P Federica D | 2009 | Cardi- ology2009，112，1： | 1 |
| 10 | Anti-tumour potential of a gallic acid-containing phenolic fraction from Oenothera biennis显示文摘 | Chiara D P Giorgia P Federica M | 2005 | Caner Lett2005，226，1： | 1 |
| 11 | Physics-based PIN diode SPICE model for power-circuit simulation 显示文摘 | GUSTAVO M B FEDERICA C GIOVANNI G | 2007 | IEEE Trans lnd Appl2007，43，4： | 1 |
| 12 | The effect of ehitosan coating on the quality and nutraceutical traits of sweet cherry during post- harvest life~显示文摘 | MILENA P FEDERICA S SILVIA P M | 2015 | Food and/3ioproeess Technology2015，8，2： | 1 |
| 13 | The wide clinical spectrum of nocturnal frontal lobe epilepsy显示文摘 | Federica P Giuseppe P Pasquale M | 2000 | Sleep Med Rev2000，4，： | 1 |
| 14 | Carbamate synthesis from amines and dimethyl carbonate under ytterbium triflate catalysis 显示文摘 | Massimo C Frandesco E Federica M | 2002 | Tetrahedron Letters2002，43，28： | 1 |
| 15 | An experimental investig ation of tetrabromobisphenol A decomposition path - ways显示文摘 | Federica B Valerio C Katia M | 2004 | Journal of Analytical and Applied Pyrolysis2004，，： | 1 |
| 16 | Role of PTEN in gastrointestinal stromal tumor progression显示文摘 | Riccardo R Nicola M Federica C | 2004 | Arch Pathol Lab Meal2004，128，4： | 1 |
| 17 | Ytterbium triflate promoted coupling reaction between aryl alkynes and aldehydes 显示文摘 | Massimo C Francesco E Federica M | 2003 | Synlett2003，，4： | 1 |
| 18 | Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes显示文摘Dear Editor,Since its first description in South Africa in November 2021,the SARS-CoV-2 Omicron variant rapidly outcompeted the previously dominating Delta variant.Omicron is the fifth variant of concern(VOC).It contains an unusually high number of mutations compared to previous VOCs,especially in the viral Spike protein,and shows high transmissibility and efficient escape of neutralizing antibodies. | Rayhane Nchioua Federica Diofano Sabrina Noettger Pascal von Maltitz Steffen Stenger Fabian Zech Jan Münch Konstantin M.J.Sparrer Steffen Just Frank Kirchhoff | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 1 |
| 19 | Thermal Degradation and Decomposition Products of Electronic Boards Containing BFRs 显示文摘 | Federica B Katia M Luigi P | 2005 | Ind Eng Chem Res2005，44，12： | 1 |
| 20 | Fatty acid composition and volatile compounds of caviar from farmed white sturgeon (Acipenser transmontanus)显示文摘 | Fabio C Vittorio M M Federica B | 2008 | Anal Chim Acta2008，217，： | 1 |
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