4篇
您的检索式：作者名="Fei Shulan"
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| 1 | Nuclear Aurora kinase A triggers programmed death-ligand 1-mediated immune suppression by activating MYC transcription in triple-negative breast cancer显示文摘Background:Increasing studies have reported that oncogenes regulate components of the immune system,suggesting that this is a mechanism for tumorigenesis.Aurora kinase A(AURKA),a serine/threonine kinase,is involved in cell mitosis and is essential for tumor cell proliferation,metastasis,and drug resistance.However,the mechanism by which AURKA is involved in immune response regulation is unclear.Therefore,this study aimed to investigate the role of AURKA in immune regulation in triple-negative breast cancer(TNBC).Methods:Peripheral blood mononuclear cells(PBMCs)were co-cultured with TNBC cells.The xCELLigence Real-Time Cell Analyzer-MP system was used to detect the killing efficiency of immune cells on TNBC cells.The expression of immune effector molecules was tested by quantitative real-time polymerase chain reaction(qRT-PCR)to evaluate immune function.Furthermore,to validate AURKA-regulated immune response in vivo,4T1 murine breast cancer cell line with AURKA overexpression or downregulation was engrafted into BALB/c mice.The distribution and proportion of immune cells in tumors were further evaluated by immunohistochemistry and flow cytometry.Results:Downregulation of AURKA in TNBC cells increased immune response by activating CD8^(+)T cell proliferation and activity.Nuclear rather than cytoplasmic AURKA-derived programmed death-ligand 1(PD-L1)expression was independent of its kinase activity.Mechanistic investigations showed that nuclear AURKA increased PD-L1 expression via an MYC-dependent pathway.PD-L1 overexpression mostly reversed AURKA silencing-induced expression of immune effector molecules,including interleukin-(IL-2),interferon-γ(IFN-γ),and perforin.Moreover,AURKA expression was negatively correlated with the enrichment and activity of tumor-infiltrating CD8^(+)T cells in 4T1 engrafted BALB/c mouse model.Conclusions:Nuclear AURKA elevated PD-L1 expression via an MYCdependent pathway and contributed to immune evasion in TNBC.Therapies targeting nuclear AURKA may restore immune responses against tumors. | Shulan Sun Wei Zhou Xiaoxi Li Fei Peng Min Yan Yajing Zhan Fan An Xiaoyan Li Yunyong Liu Quentin Liu Haozhe Piao | 2021 | Cancer Communications2021，41，9： | 2 |
| 2 | Methods of Measuring and Decomposing the Income Gap: A Survey显示文摘本文按研究对象将收入差距划分为总体收入差距和组群收入差距两大类,从收入不平等、极化和组群收入差距三个层面梳理了收入差距的测度及其分解方法。其中,收入不平等侧重于对总体收入差距的刻画;极化着眼于收入分布中的“聚集”或“扎堆”现象,其衡量指标大体上可分为两极分化测度指标和多极分化测度指标。在收入差距的分解上,Shapley分解和组群收入差距的分布分解方法都是较为前沿的研究领域。文章还强调了各种收入差距衡量指标或分解方法的适用性和针对性,以便有的放矢地选用合适的相关指标和方法,更精准地探寻收入差距的成因。 | Guo Jiqiang Jiang Li Lu Lili Ye Rongde Fei Shulan | 2011 | Social Sciences in China2011，32，3： | 2 |
| 3 | SHP‐2 phosphatase promotes cervical cancer cell proliferation through inhibiting interferon‐β production显示文摘 | Fei Meng Xiaoyun Zhao Shulan Zhang | 2012 | Journal of Obstetrics and Gynaecology Research2012，，1： | 1 |
| 4 | Lead toxicity thresholds in 17 Chinese soils based on substrate-induced nitrification assay显示文摘The influence of soil properties on toxicity threshold values for Pb toward soil microbial processes is poorly recognized. The impact of leaching on the Pb threshold has not been assessed systematically. Lead toxicity was screened in 17 Chinese soils using a substrate-induced nitrification(SIN) assay under both leached and unleached conditions.The effective concentration of added Pb causing 50% inhibition(EC50) ranged from 185 to> 2515 mg/kg soil for leached soil and 130 to > 2490 mg/kg soil for unleached soil. These results represented > 13- and > 19-fold variations among leached and unleached soils,respectively. Leaching significantly reduced Pb toxicity for 70% of both alkaline and acidic soils tested, with an average leaching factor of 3.0. Soil p H and CEC were the two most useful predictors of Pb toxicity in soils, explaining over 90% of variance in the unleached EC50 value. The relationships established in the present study predicted Pb toxicity within a factor of two of measured values. These relationships between Pb toxicity and soil properties could be used to establish site-specific guidance on Pb toxicity thresholds. | Ji Li Yizong Huang Ying Hu Shulan Jin Qiongli Bao Fei Wang Meng Xiang Huiting Xie | 2016 | Journal of Environmental Sciences2016，28，6： | 0 |
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