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| 1 | Multi-scale HPC system for multi-scale discrete simulation—Development and application of a supercomputer with 1 Petaflops peak performance in single precision显示文摘A supercomputer with 1.0 Petaflops peak performance in single precision,designed and established by Institute of Process Engineering,Chinese Academy of Sciences,is introduced in this brief communication.A designing philosophy utilizing the similarity between hardware,software and the problems to be solved is embodied,based on the multi-scale method and discrete simulation approaches developed at Institute of Process Engineering(IPE)and implemented in a graphic processing unit(GPU)-based hybrid computing mode.The preliminary applications of this machine in areas of multi-phase flow,molecular dynamics and so on are reported,demonstrating the supercomputer as a paradigm of green computation in new architecture. | Feiguo Chen Wei Ge Li Guo Xianfeng He Bo Li Jinghai Li Xipeng Li Xiaowei Wang Xiaolong Yuan | 2009 | Particuology2009，7，4： | 19 |
| 2 | Quasi-real-time simulation of rotating drum using discrete element method with parallel GPU computing显示文摘Real-time simulation of industrial equipment is a huge challenge nowadays. The high performance and fine-grained parallel computing provided by graphics processing units (GPUs) bring us closer to our goals. In this article, an industrial-scale rotating drum is simulated using simplified discrete element method (DEM) without consideration of the tangential components of contact force and particle rotation. A single GPU is used first to simulate a small model system with about 8000 particles in realtime, and the simulation is then scaled up to industrial scale using more than 200 GPUs in a 1D domain-decomposition parallelization mode. The overall speed is about 1/11 of the real-time. Optimization of the communication part of the parallel GPU codes can speed up the simulation further, indicating that such real-time simulations have not only methodological but also industrial implications in the near future. | Ji Xu Huabiao Oi Xiaojian Fang Liqiang Lu Wei Ge Xiaowei Wang Ming xu Feiguo Chen xianfeng He Jinghai Li | 2011 | Particuology2011，9，4： | 16 |
| 3 | Molecular dynamics simulation of complex multiphase flow on a computer cluster with GPUs显示文摘Compute Unified Device Architecture (CUDA) was used to design and implement molecular dynamics (MD) simulations on graphics processing units (GPU). With an NVIDIA Tesla C870, a 20-60 fold speedup over that of one core of the Intel Xeon 5430 CPU was achieved, reaching up to 150 Gflops. MD simulation of cavity flow and particle-bubble interaction in liquid was implemented on multiple GPUs using a message passing interface (MPI). Up to 200 GPUs were tested on a special network topology, which achieves good scalability. The capability of GPU clusters for large-scale molecular dynamics simulation of meso-scale flow behavior was, therefore, uncovered. | CHEN FeiGuo GE Wei LI JingHai | 2009 | Science China Chemistry2009，52，3： | 9 |
| 4 | Pseudo-particle modeling for gas flow in microchannels显示文摘The velocity profiles and temperature distributions of gas flow in microchannels, for Knudsen numbers ranging from 0.01 to 0.20, are investigated with pseudo-particle modeling (PPM). It has been found that the velocity profiles are mainly affected by Knudsen number and the external force fields applied. When Knudsen number was increased, the slip velocities on the walls increased at the beginning, and then decreased. The temperature distributions were also significantly affected by the external force. The Darcy friction factor increased with increasing Knudsen number, and its variation with Mach number under increased Knudsen number was similar to the so-called premature laminar-turbulent transition observed in experiments. | WANG LiMin GE Wei CHEN FeiGuo | 2007 | Chinese Science Bulletin2007，52，4： | 5 |
| 5 | Chronic acalculous cholecystitis:correlation of clinical assessment,laboratory data and final histopathology显示文摘Objective:To summarize and analyze the clinical and histopathological features of chronic acalculous cholecystitis (CAC) and to investigate the diagnosis and surgical treatment of chronic acalculous cholecystit.Methods:The study subjects were 39 patients with chronic biliary symptoms but no evidence of stones in the gallbladder by B ultrasonography and magnetic resonance cholopancreatography (MRCP) (CAC group).The CCC group consisted of 66 patients taken randomly from concurrent all patients of chronic calculous cholecystitis (CCC).All patients accepted fibergastroscopy,B ultrasonography,MRCP,laboratory examination preoperatively.We retrospectively analyzed the clinical features,B ultrasonography and MRCP findings,histopathological results and clinical outcomes between the two groups.Results:All the 39 patients were diagnosed by clinical symptoms,B ultrasonography,fatty meal gallbladder contractability studies under ultrasound,fibergastroscopy and magnetic resonance cholangiopancreatography (MRCP),what's more,they were pathologically verified postoperatively.In all patients,there was a complete absence of gallbladder wall contractability.Mucosa epithelial defect was found in 21 patients in CAC group (53.8%) and 16 patients in CCC group (24.2%) respectively (P<0.005).Thickened arteriole wall was found in 29 patients in CAC group (74.4%) and none patient in CCC group (P<0.0001).Thickened gallbladder wall (4 mm or more in thickness) was found in 33 patients in CAC group (84.6%) and 28 patients in CCC group (42.4%) respectively (P<0.005).Bile stasis was found in 23 patients in CAC group (59.0%) and 14 patients in CCC group (21.2%) respectively by ultrasonography preoperatively and confirmed in operation (P<0.005).The outcomes of cholecystectomy,expressed as total or near total relief,was similar in the two groups.No statistically significant differences were observed between patients with CAC (90%) and CCC (80%),the P-value >0.05.Conclusion:Chronic acalculous cholecystitis could be diagnosed by symptoms,ultrasound,fatty meal gallbladder contractability studies under untrasoundand MRCP.The optimal treatment of chronic acalculous cholecystitis characterized by thickened arteriole wall and mucosa epithelial defect is cholecystectomy. | Yan Jianjun Zhu Qian Shen Jun Zhou Feiguo Huang Liang Liu Caifeng Zhang Xianghua Cong Wenming Yan Yiqun | 2012 | Journal of Medical Colleges of PLA(China)2012，27，2： | 4 |
| 6 | Numerical investigation of granular flow similarity in rotating drums显示文摘The theory of flow similarity has not been well established for granular flows,in contrast to the case for conventional fluids,owing to a lack of reliable and general constitutive laws for their continuum description.A rigorous investigation of the similarity of velocity fields in different granular systems would be valuable to theoretical studies.However,experimental measurements face technological and physical problems.Numerical simulations that employ the discrete element method(DEM) may be an alternative to experiments by providing similar results,where quantitative analysis could be implemented with virtually no limitation.In this study,the similarity of velocity fields is investigated for the rolling regime of rotating drums by conducting simulations based on the DEM and using graphics processing units.For a constant Froude number,it is found that the particle-to-drum size ratio plays a dominant role in the determination of the velocity field,while the velocity field is much more sensitive to some material properties than to others.The implications of these findings are discussed in terms of establishing theoretical similarity laws for granular flows. | Huabiao Qi Ji Xu Guangzheng Zhou Feiguo Chen Wei Ge Jinghai Li | 2015 | Particuology2015，13，5： | 4 |
| 7 | Statistical properties of pseudo-particle systems显示文摘Pseudo-particle modeling(PPM),a molecular modeling method which combines time-driven algorithms and hard molecule modeling,was originally developed for simulating gas in complex multiphase systems(Ge & Li,2003;Ge et al.,2005;Ge,1998).In this work,the properties of two-and three-dimensional pseudo-particle systems,namely,mean free path,compressibility factor,self-diffusion coefficient and shear viscosity,are systematically measured by using PPM.It is found that in terms of an effective diameter,the results well conform to the Chapman-Enskog theory,thus suggesting that PPM can be employed to simulate the micro-and meso-scale behavior of ordinary gas and fluid flows. | Feiguo Chen Wei Ge | 2010 | Particuology2010，8，4： | 3 |
| 8 | Long-term survival for spontaneous rupture of hepatocellular carcinoma treated with hepatectomy显示文摘Objective:To determine the prognostic factors of ruptured hepatocellular carcinoma(HCC) and report the management of patients with spontaneous rupture of HCC in a single center during a 5-year period and to evaluate one-stage hepatectomy.Methods:A series of 4,209 patients with HCC were collected at Eastern Hepatobiliary Surgery Hospital from April 2002 to November 2006,of whom 200 patients(4.8%) with ruptured HCC were studied retrospectively regarding their clinical characteristics and prognostic factors.The one-stage therapeutic approach to manage ruptured HCC consisted of initial management by conservative method,transarterial embolization(TAE) or surgical hepatectomy.Results of various treatments were evaluated and compared in the randomly selected 202 patients with no history of rupture during the same study period.Results:A total of 200 patients with spontaneous rupture of HCC were studied who underwent surgical treatment(n=105),TAE 33 and conservative treatment(ConT 62).A multivariate analysis using the Cox hazard regression model(including all the patients;n=200) identified surgical hepatectomy as the only independent factor determining a relatively long survival period(P<0.0001).On the other hand,in a further analysis of the patients in whom surgical hepatectomy was successfully performed(n=105),which identified a maximum tumor size exceeding 6 cm as significant determinants of a poor 12-month(P=0.036),and a multivariate analysis did not identify as any inverse independent factor determining relatively long-term survival,only a maximum tumor size exceeding 6 cm exhibited a tendency toward being a determinant factor(P=0.083).Conclusion:Considering the high propensity to spontaneous rupture,as long as preoperatively clinical evaluation meet surgery requirements,elective one-stage hepatectomy for patients with ruptured HCC is the first treatment option.Prolonged survival could be achieved in selected patients with hepatic resection,although the survival results were inferior to those of the patients who did not have the complication of rupture. | Zhu Qian Yan Jianjun Zhang Xianghua Cao Jie Huang Liang Li Jing Shen Jun Zhou Feiguo Yan Yiqun | 2012 | Journal of Medical Colleges of PLA(China)2012，27，3： | 2 |
| 9 | Lanthanum Inhibited the Binding of LPS with Monocyte and CD 14 Expression Upregulation显示文摘To investigate the effects of lanthanum chloride on binding of LPS to monocyte and CD14 expression upregulation induced by LPS, human monocytes were analyzed by flow cytometry (FCM). The results indicated that lanthanum chloride could decrease the binding rate of LPS with monocyte significantly. LPS upregulated the expression of CD14 on monocyte in dose dependant manner, however, lanthanum chloride could inhibit the increase of CD14 expression on monocytes by halves. Cellular & Molecular Immunology.2004; 1(5):392-394. | YangWang FeiGuo FengHu GongxianWang GuohuiLi | 2004 | Cellular & Molecular Immunology2004，1，5： | 2 |
| 10 | Biological effects of extract from newborn porcine liver on hepatocytes,hepatic stellate cells,and hepatoma cell line显示文摘Objective: Porcine liver extract has been shown to be effective in the clinical treatment of severe hepatitis. The aim of the present study was to study its antifibrotic as well as immune regulatory effect in vitro. Methods: Hepatocytes, hepatic stellate cells (HSCs), hepatoma cell line (HepG2) and human peripheral blood mononuclear cells (PMNCs) were studied with respect to proliferation, extracellular matrix production and apoptotic activities by proliferation assay, radioimmunoassay, gene transfection, reporter gene analysis and flow cytometry, respectively. Results: A strong stimulatory proliferation effect was observed in hepatocytes, and an inhibitory effect was found in HSCs. Hyaluronic acid (HA) production and reporter gene activities driven by various α1(I) procollagen gene promoters in HSC-T6 were significantly decreased after treatment with the extract. Fluo-Anexin V binding apoptotic HepG2 cells were more prominent in the presence of 60 μg/ml extract. More CD4+/CD69+ positive T lymphocytes existed in the presence of the extract. Conclusion: Porcine liver extract is effective for antifibrogenesis via hepatocyteregeneration, HSC and hepatoma cell inhibition in vitro. The elevation of active T lymphocytes is helpful for immune surveillance. Fine mapping of the extract is necessary in order to get definite molecules which are essential in all described functions. | Zhou Changlin Zhou Feiguo Gao Chunfang Wang Hao Xu Lingling Zhang Lingzheng Chen Jie | 2008 | Journal of Medical Colleges of PLA(China)2008，23，6： | 1 |
| 11 | Pulmonary embolism after transcatheter arterial chemoembolization for hepatocellular carcinoma:a retrospective analysis on 10 years' experience显示文摘Objective:To study the clinical characteristics and treatment of pulmonary embolism(PE)after transcatheter arterial chemoembolization(TACE)for hepatocellular carcinoma(HCC).Methods:The clinical records of 13 512 patients diagnosed with HCC and received TACE from January 2000 to December 2009 were reviewed.Among these patients,5 031 were allocated into group A who had one or more disorders like diabetes,hypertension,coronary heart disease,obesity or varicose vein of lower limb,while the other 8 481 patients who did not have such disorders were in group B.Results:A total of 39 185 TACE procedures were performed for the 13 512 patients.Five(0.01%)patients in group A developed PE after TACE,of whom two recovered 4 and 5 d later with early anticoagulant therapy while the hypertension,coronary heart disease,obesity or varicose vein of lower limb are possibly more likely to develop PE other 3 died of respiratory failure within 5 h.The mortality of PE was 60%(3/5).Conclusion:HCC patients with diabetes, after TACE than those without such disorders.Patients who have such disorders should be more carefully observed after TACE and early treatment with heparin should be applied once PE develops. | Li Jing YanYiqun Huang Liang Yan Jianjun Zhou Feiguo Zhang Xianghua Liu Caifeng | 2011 | Journal of Medical Colleges of PLA(China)2011，26，3： | 1 |
| 12 | Numerical study on gas–liquid nano-flows with pseudo-particle modeling and soft-particle molecular dynamics simulation显示文摘 | Feiguo Chen Wei Ge Limin Wang Jinghai Li | 2008 | Microfluidics and Nanofluidics2008，，5： | 1 |
| 13 | Eulerian–Lagrangian simulation of bubble coalescence in bubbly flow using the spring-dashpot model显示文摘The Eulerian–Lagrangian simulation of bubbly flow has the advantage of tracking the motion of bubbles in continuous fluid, and hence the position and velocity of each bubble could be accurately acquired. Previous simulation usually used the hard-sphere model for bubble–bubble interactions, assuming that bubbles are rigid spheres and the collisions between bubbles are instantaneous. The bubble contact time during collision processes is not directly taken into account in the collision model. However, the contact time is physically a prerequisite for bubbles to coalesce, and should be long enough for liquid film drainage. In this work we applied the spring-dashpot model to model the bubble collisions and the bubble contact time, and then integrated the spring-dashpot model with the film drainage model for coalescence and a bubble breakage model. The bubble contact time is therefore accurately recorded during the collisions. We investigated the performance of the spring-dashpot model and the effect of the normal stiffness coefficient on bubble coalescence in the simulation.The results indicate that the spring-dashpot model together with the bubble coalescence and breakage model could reasonably reproduce the two-phase flow field, bubble coalescence and bubble size distribution. The influence of normal stiffness coefficient on simulation is also discussed. | Jing Xue Feiguo Chen Ning Yang Wei Ge | 2017 | Chinese Journal of Chemical Engineering2017，25，3： | 0 |
| 14 | Quantifying growth and breakage of agglomerates in fluid-particle flow using discrete particle method显示文摘The cohesive solids in liquid flows are featured by the dynamic growth and breakage of agglomerates, and the difficulties in the development, design and optimization of these systems are related to this significant feature.In this paper, discrete particle method is used to simulate a solid–liquid flow system including millions of cohesive particles, the growth rate and breakage rate of agglomerates are then systematically investigated. It was found that the most probable size of the agglomerates is determined by the balance of growth and breakage of the agglomerates the cross point of the lines of growth rate and breakage rate as a function of the particle numbers in an agglomerate, marks the most stable agglomerate size. The finding here provides a feasible way to quantify the dynamic behaviors of growth and breakage of agglomerates, and therefore offers the possibility of quantifying the effects of agglomerates on the hydrodynamics of fluid flows with cohesive particles. | Lingfeng Zhou Junwu Wang Wei Ge Shiwen Liu Jianhua Chen Ji xu Limin Wang Feiguo Chen Ning Yang Rongtao Zhou Lin Zhang Qi Chang Philippe Ricoux Alvaro Fernandez | 2018 | Chinese Journal of Chemical Engineering2018，26，5： | 0 |
| 15 | NURBS-based DEM for non-spherical particles显示文摘The discrete element method(DEM)is used to analyze complex practical granular systems;however,the representation of real shapes is an important consideration because behavior of non-spherical particles is unlike that of spherical particles both individually and collectively.In this study,we use non-uniform rational basis-splines(NURBS)to describe the shapes of non-spherical particles and introduce a contact detection scheme based on quadratic convergence,to simulate the behaviors of elliptical particles.The simulation results are compared with those based on polygons,in terms of the shape description and contact treatment,to demonstrate the high accuracy and efficiency of NURBS-based DEM. | Shiwen Liu Feiguo Chen Wei Ge Philippe Ricoux | 2020 | Particuology2020，18，2： | 0 |
| 16 | Sorafenib in hepatocellular carcinoma:efficacy and predictive factors显示文摘Objective:To evaluate the efficacy and safety in patients with hepatocellular carcinoma treated with sorafenib and determine the predictive factors for survival.Methods:From April 2009 to December 2010,all patients with hepatocellular carcinoma treated with sorafenib were included in the study.Clinical data and survival time were collected.Survival analysis was conducted using the Kaplan-Meier method,and predictive factors for survival were analysed using the Cox's model.Results:A total of 51 patients were included in the study,the median time of follow-up was 10 months(range 1-22).All the 51 patients had one or more adverse events,of which 2 patients died of upper gastrointestinal bleeding and 6 patients discontinued treatment.The mean survival time was 11 months and 1-year survival was 60.8%.On univariate analysis,the median survival time of patients with tumors of BCLC A,B and C were 17,12.5 and 8.5 months,and 1-year survival were 71.4%,61.1%,and 23.1%, respectively(P=0.006).Compared with those with mild and poor arterial supply tumors,patients with good arterial supply tumors had longer median survival time(12 months vs 8 months and 9 months) and higher 1-year survival(52.0%vs 30.8%and 38.5%)(P=0.037).Patients with portal invasion had shorter median survival time and lower 1-year survival(8.5 months vs 13 months and 57.6%vs 16.7%,respectively) than those without(P=0.012).Patients with prealbumin≥170 mg/L had longer median survival time and higher 1-year survival(13.5 months vs 9 months and 55.6%vs 36.4%,respectively) than those with prealbumin<170 mg/L(P=0.016).Early tumor BCLC staging and high level of prealbumin were independent predictive factors for survival on multivariate analysis using Cox's regression model,the hazard ratio were 3.69(95%CI:1.30-10.53,P=0.015) and 3.53(95%CI:1.40-8.91,P=0.008) respectively.Conclusion:Upper gastrointestinal bleeding was a severe event need to be concerned in patients with hepatocellular carcinoma treated with sorafenib.Patients with high level of prealbumin could benefit more from sorafenib treatment,and prealbumin could be a predictor for survival in HCC patients treated with sorafenib. | Li Jing Huang Liang Yan Jianjun Zhou Feiguo Liu Caifeng Yan Yiqu | 2011 | Journal of Medical Colleges of PLA(China)2011，26，6： | 0 |
| 17 | Lignosulfonate and Its Derivatives for Oil-well Drilling:A Concise Review显示文摘Lignosulfonate,a byproduct of the pulp and paper industry,has been used in the oil-well drilling industry for a significant amount of time.Lignosulfonate and its derivatives serve different roles in the oil-well drilling industry because of their unique structures and properties.This review summarizes lignosulfonate and its derivatives,including lignosulfonate complexed with metal ions,lignosulfonate graft copolymers,lignosulfonatetannin complexes,and other lignosulfonate-containing composites,in terms of their preparation,properties,and potential applications in oil-well drilling industry.It provides readers with a quick review of existing studies in this area and some inspirations for future studies pertaining to the utilization of lignosulfonate-based materials in the oil-well drilling industry. | Ping He Lei Dai Xinyu Li Zongjian Yang Feiguo Hua Liang Li Bing Wei | 2021 | Paper And Biomaterials2021，6，2： | 0 |
| 18 | Inhibition of NMDA receptor and GSK3β vmediates the fast onset of antidepressant like natural product显示文摘OBJECTIVE To investigate the fast antidepressant effect and the underlying mechanism of it.METHODS C57BL/6 mice were exposed to a 6-week chronic unpredictable mild stress(CUMS)protocol,and treated with YY-23 or a positive drug fluoxetine in the last 3weeks,behavioral assessments proceed every week.NMDA-induced current were recorded by whole-cell patch clamp on dissociated hippocampal CA1 neurons of Sprague-Dawley rats.Phosphorylation of the signaling proteins was evaluated by Western blotting.RESULTS The electrophysiological results showed that YY-23 is a non-competitive NMDA receptor antagonist,neither in′use-dependent′nor′voltage-dependent′way,with no prominent effect on AMPA induced current.This antagonism of YY-23 could be partially prevented by proven blockers MK801 and Mg2+,laterally indicating the nature of NMDA receptor antagonist both pharmacologically and physiologically.Behavioral and Biochemical study showed that YY-23 could act as antidepressant and exerted strong inhibitory effect on GSK3β in PFC of CMS depression mice model.CONCLUSION YY-23 showed promising antidepressant effect with rapid onset,which might be related to NMDA receptor antagonism and GSK3β inhibition. | QiZHANG FeiGUO Zhi-WenFU BingZHANG Cheng-GangHUANG YangLI | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 0 |
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