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| 1 | Targeting circular RNAs as a therapeutic approach: current strategies and challenges显示文摘Significant progress has been made in circular RNA(circRNA)research in recent years.Increasing evidence suggests that circRNAs play important roles in many cellular processes,and their dysregulation is implicated in the pathogenesis of various diseases.CircRNAs are highly stable and usually expressed in a tissue-or cell type-specific manner.Therefore,they are currently being explored as potential therapeutic targets.Gain-of-function and loss-of-function approaches are typically performed using circRNA expression plasmids and RNA interference-based strategies,respectively.These strategies have limitations that can be mitigated using nanoparticle and exosome delivery systems.Furthermore,recent developments show that the cre-lox system can be used to knockdown circRNAs in a cell-specific manner.While still in the early stages of development,the CRISPR/Cas13 system has shown promise in knocking down circRNAs with high specificity and efficiency.In this review,we describe circRNA properties and functions and highlight their significance in disease.We summarize strategies that can be used to overexpress or knockdown circRNAs as a therapeutic approach.Lastly,we discuss major challenges and propose future directions for the development of circRNA-based therapeutics. | Alina T.He Jinglei Liu Feiya Li Burton B.Yang | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 5 |
| 2 | Influence of traffic on the temperature field of tunnel in cold region:A case study on the world’s longest highway spiral tunnel显示文摘The impact of the piston wind caused by vehicle traffic on the temperature field distribution of the tunnel cannot be ignored,especially in spiral tunnels,where the temperature field distribution is more complicated than that in straight tunnels.Based on the world’s longest highway spiral tunnel,this study explores the influence of traffic on the temperature fields of spiral and straight tunnels,and proposes a new design method for laying length of insulation layer.The results show that traffic has a significant effect on the temperature field dis-tribution in the tunnel.The influence degree of different traffic elements decreases in the following order:average vehicle speed>daily traffic>morning rush hour>evening rush hour.The temperature field distribution of spiral tunnels is asymmetry on the left and right compared with straight tunnels,while the influence degree of traffic on the outside of spiral tunnels is similar to that of straight tunnels.Due to the difference of wind direction and traffic direction at different tunnel openings,an asymmetric insulation layer laying method is proposed.It is suggested that the lengths of the insulation layers of the Jinjiazhuang Tunnel should be 1200 m for the right tunnel inlet,700 m for the right tunnel outlet,700 m for the left tunnel inlet,and 1400 m for the left tunnel outlet. | Yifan Jiang Jianyou Yu Ping Zhou Feicong Zhou Jiayong Lin Jinyi Li Ming Lin Feiya Lei Zhijie Wang | 2023 | Underground Space2023，，1： | 2 |
| 3 | Proteomic Analysis of High Temperature Stress-Responsive Proteins in Chrysanthemum Leaves显示文摘Chrysanthemum is one of the most important ornamental flowers in the world,and temperature has a significant influence on its field production.In the present study,differentially expressed proteins were investigated in the leaves of Dendranthema grandiflorum‘Jinba’under high temperature stress using label-free quantitative proteomics techniques.The expressed proteins were comparatively identified and analyzed.A total of 1,463 heat-related,differentially expressed proteins were successfully identified by Liquid Chromatography-tandem Mass Spectrometry(LC-MS/MS),and 1,463 heat-related,differentially expressed proteins were successfully identified by mass spectrometry after a high temperature treatment.Among these,701 proteins were upregulated and 762 proteins were downregulated.The in-depth bioinformatics analysis of these differentially expressed proteins revealed that these were involved in energy metabolism pathways,protein metabolism,and heat shock.In the present study,the investigators determined the changes in the levels of some proteins,and their expression at the protein and molecular levels in chrysanthemum to help reveal the mechanism of heat resistance in chrysanthemum.Furthermore,the present study elucidated some of the proteins correlated to heat resistance in chrysanthemum,and their expression changes at the protein and molecular levels to help reveal the mechanism of heat resistance in this flower species.These results provide a theoretical basis for the selection of new heat resistant varieties of chrysanthemum in the field. | Xin Li Feiya Liao Qiqi Ma Beibei Jiang Yuanzhi Pan Cheng Luo Xinjie Wang Aining Ran | 2021 | Phyton-International Journal of Experimental Botany2021，90，5： | 1 |
| 4 | Force measurement of the integrin-fibronectin interaction显示文摘 | Feiya Li Redick SD Erickson HP | 2003 | Biophys J2003，84，： | 1 |
| 5 | Force measurements of the a5/31 integrin-fibronectin interaction显示文摘 | LI Feiya REDICK S D ERICKSON H P | 2003 | Biophys J2003，84，2： | 1 |
| 6 | Analysis of the Role of General Practitioners Services in Rural Areas during the COVID-19 Epidemic显示文摘Since the outbreak of the COVID-19,various regions of China have been rapidly deployed under the leadership of the Central Committee of the Party to actively prevent and control the COVID-19.The rural areas of my country have weak links to the prevention and management of public health emergencies.Problems include lack of medical and health resources and farmers’low awareness of epidemic prevention.Situations that correspond to the prevention and management of the COVID-19 are more serious.As the patient’s first contact and“gatekeeper”in the fight against the epidemic,the general practitioner is responsible for the“first visit-subsequent ongoing intervention”.This article is about the prevention and control of the COVID-19 epidemics and epidemic prevention in terms of dissemination of knowledge,informed crowd control,joint prevention and control,and standardized management of people.This is a summary of the efforts of general practitioners.Quarantine at home,interactive referrals to medical consortiums,special care for contracted families.The function during the management period aims to analyze the role played by general practitioners during the epidemic and to provide new ideas for the prevention and management of the epidemic.Provide more targeted general practitioner-style services in rural areas to promote the implementation and improvement of health and poverty alleviation.The health level of the rural population provides a theoretical standard. | Zuohua Liu Feiya Li Zihan Liu Qiuxia Wu Xiangyu Li Qiang Wang | 2021 | Journal of Advances in Medicine Science2021，4，2： | 1 |
| 7 | Simultaneous determination of ten nucleosides and bases in Ganoderma by micellar electrokinetic chromatography显示文摘Ganoderma(lingzhi)is a famous herbal medicine and edible supplement in oriental countries for a long history.In this study,a simple micellar electrokinetic chromatography(MEKC)method was established for the analysis of nucleosides and bases,the major bioactive components in Ganoderma for the first time.By optimizing the borate concentration,the sodium dodecyl sulfate(SDS)concentration and the pH value of running buffer,10 nucleosides and bases achieved an ideal separation.In real sample analysis,the developed method was successfully used to determine the 10 target analytes in 23 batches of Ganoderma samples from different regions.Results indicated that contents of 10 investigated analytes in each sample showed obvious variation.The principal components analysis(PCA)and hierarchical cluster analysis(HCA)analysis classified the samples into three groups,and the HCA tree visualized the relationships which was mainly contributed by geographical partition.The results indicated geographical origin to be an important factor that affect the accumulation of nucleosides and bases in Ganoderma.In summary,this study provides a simple and practical strategy for quality assessment and cultivation reference of Ganoderma. | Feiya Sheng Songsong Wang Xiao Luo Jianbo Xiao Linfeng Hu Peng Li | 2022 | Food Science and Human Wellness2022，11，2： | 1 |
| 8 | Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells显示文摘全身的豺狼座 erythematosus (SLE ) 的一个特点是由汽车反应的 B 房间的各种各样的自身抗体的一致生产。Interferon-α(IFN-α) 发信号高度在 SLE B 房间被激活并且由 B 房间在抗体反应起一个重要作用。以前的研究证明了 CD180 否定的 B 房间,戏剧性地在 SLE 病人被增加,为自身抗体的生产负责。然而,在 CD180 和 IFN-α 之间的协会;未知的发信号的遗体。在现在的学习,我们在调整 IFN-α 的激活上探索了 CD180 的效果;在 B 房间发信号。我们发现 CD180 否定的 B 房间的数字在 MRL/Mp-Fas (lpr/lpr ) 被增加豺狼座容易的老鼠与野类型的老鼠相比。Phenotypic 分析证明 CD180 否定的 B 房间包括了 CD138 + plasmablast/plasma 房间和 GL-7 + 幼芽的中心(GC ) B 房间。尤其是, CD180 的结扎显著地禁止了 IFN-α信号变换器的导致的 phosphorylation 和抄写 2 的使活跃之物(STAT-2 ) 和以在 vitro 的一种 Lyn-PI3K-BTK-dependent 方式的刺激 IFN 的基因(ISG ) 的表示。而且, CD180 的结扎能也禁止 IFN-α在在 vivo 的 B 房间的导致的 ISG 表示。而且,像使用费的受体 7 并且像使用费的受体 9 发信号小径能显著地 downregulate CD180 表示并且调制在 IFN-α 的激活上发信号的 CD180 的禁止的效果;发信号。一起,我们的结果加亮在 CD180 否定的 B 房间的增加的比例和 IFN-α 的激活之间的靠近的协会;在 SLE 发信号。我们的数据提供分子的卓见进 IFN-α 的机制;在为 SLE 处理的 SLE B 房间和一条潜在的治疗学的途径的发信号的激活。 | Ming You Guanjun Dong Fanlin Li Feiya Ma Jing Ren Yujun Xu Huimin Yue Ruijing Tang Deshan Ren Yayi Hou | 2017 | Cellular & Molecular Immunology2017，14，2： | 0 |
| 9 | Direct synthesis of moirésuperlattice through chemical vapor deposition growth of monolayer WS_(2)on plasma-treated HOPG显示文摘Vertical van der Waals(vdW)heterostructures composed of two-dimensional(2D)layered materials have recently attracted substantial interests due to their unique properties.However,the direct synthesis of moirésuperlattice remains a great challenge due to the difficulties in heterogeneous nucleation on smooth vdW surfaces.Here,we report a controllable chemical vapor deposition growth of complete monolayer WS_(2)on highly ordered pyrolytic graphite(HOPG)substrates through the plasma pretreatment.The results show that the morphologies of the grown WS_(2)have a strong dependence on the plasma parameters,including gas composition,source power,and treatment time.It is found that the surface C–C bonds are broken in the plasma pretreated HOPG,and the formed small clusters can act as the nucleation sites for the subsequent growth of WS_(2).Moreover,the height of clusters dominates the growth mode of WS_(2)islands.A transition from a 2D mode to three-dimensional(3D)growth mode occurs when the height is higher than the interlayer spacing of the heterostructure.Besides,diverse moirésuperlattices with different twist angles for WS_(2)/HOPG heterostructures are observed,and the formation mechanism is further analyzed by firstprinciples calculations. | Xiaowen Zhou Zongnan Zhang Xinlong Zeng Yaping Wu Feiya Xu Chunmiao Zhang Xu Li Zhiming Wu Junyong Kang | 2022 | Nano Research2022，15，9： | 0 |
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