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| 1 | Acoustic sound speed profile inversion based on orthogonal matching pursuit显示文摘The estimation of ocean sound speed profiles(SSPs)requires the inversion of an acoustic field using limited observations.Such inverse problems are underdetermined,and require regularization to ensure physically realistic solutions.The empirical orthonormal function(EOF)is capable of a very large compression of the data set.In this paper,the non-linear response of the sound pressure to SSP is linearized using a first order Taylor expansion,and the pressure is expanded in a sparse domain using EOFs.Since the parameters of the inverse model are sparse,compressive sensing(CS)can help solve such underdetermined problems accurately,efficiently,and with enhanced resolution.Here,the orthogonal matching pursuit(OMP)is used to estimate range-independent acoustic SSPs using the simulated acoustic field.The superior resolution of OMP is demonstrated with the SSP data from the South China Sea experiment.By shortening the duration of the training set,the temporal correlation between EOF and test sets is enhanced,and the accuracy of sound velocity inversion is improved.The SSP estimation error versus depth is calculated,and the 99%confidence interval of error is within±0.6 m/s.The 82%of mean absolute error(MAE)is less than 1 m/s.It is shown that SSPs can be well estimated using OMP. | Qianqian Li Juan Shi Zhenglin Li Yu Luo Fanlin Yang Kai Zhang | 2019 | Acta Oceanologica Sinica2019，38，11： | 4 |
| 2 | A Post- Processing Method for the Removal of Refraction Artifacts in Multibeam Bathymetry Data 显示文摘 | Fanlin Yang Jiabiao Li Ziyin Wu | 2007 | Marine Geodesy2007，30，3： | 1 |
| 3 | A benzenediamine derivate FC-99 attenuates lupus nephritis in MRLIIpr mice via inhibiting myeloid dendritic cell-secreted BAFF显示文摘Myeloid 树枝状的房间(DC ) 能生产调制 B 房间的幸存和区别并且在全身的豺狼座 erythematosus (SLE ) 的致病起一个枢轴的作用的 B-cell-activating 因素(BAFF ) 。像使用费的受体 4 (TLR4 ) 发信号在 BAFF 的进程有重要函数生产。我们的以前的学习证明 benzenediamine derivate FC-99 拥有反发炎活动并且直接与 interleukin-1 交往联系受体的 kinase 4 (IRAK4 ) ,它是在 TLR4 发信号的一个枢轴的分子。在这研究,我们证明 FC-99 在 MRL/lpr 老鼠稀释了豺狼座肾炎。FC-99 也减少了在 sera 的全部的免疫球蛋白 G (IgG ) 的层次,全部的 IgG2a 和 IgM,以及在 MRL/lpr 老鼠的怒气的 B 房间的激活。而且, FC-99 在怒气禁止了 myeloid DC 的反常激活并且在 MRL/lpr 老鼠的 sera,怒气,和肾减少了 BAFF 的层次。在有在 vitro 的 lipopolysaccharide 的 TLR4 刺激之上,而且, FC-99 在鼠科的骨头禁止了 IRAK4 phosphorylation,以及激活和 BAFF 生产导出髓的 DC。这些数据显示 FC-99 经由禁止藏匿 DC 的 BAFF 在 MRL/lpr 鼠标稀释豺狼座肾炎,建议那 FC-99 可以是 SLE 的处理的一个潜在的治疗学的候选人。 | Jianjian Ji Jingjing Xu Fanlin Li Xiaojing Li Wei Gong Yuxian Song Huan Dou Yayi Hou | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 1 |
| 4 | Precise positioning of underwater static objects without sound speed profile 显示文摘 | YANG Fanlin LU Xiushan LI Jiabiao etal | 2011 | Marine Geodesy ( S0149- 0419 )2011，34，2： | 1 |
| 5 | Precise positioning of underwater static objects without sound speed Profile显示文摘 | YANG Fanlin LU Xiushan LI Jiabiao | 2011 | Marine Geodesy(S0149-0419)2011，34，2： | 1 |
| 6 | A Post-processing method for the removal of refraction artifacts in mulfibeam bathy- merry data显示文摘 | YANG Fanlin LI Jiabiao WU Ziyin | 2007 | Marine Geodesy(0149-0419)2007，30，3： | 1 |
| 7 | Comparison of two Bayesian-point-estimation methods in multiple-source localization显示文摘Environmental uncertainty represents the limiting factor in matched-field localization. Within a Bayesian framework, both the environmental parameters, and the source parameters are considered to be unknown variables. However, including environmental parameters in multiple-source localization greatly increases the complexity and computational demands of the inverse problem. In the paper, the closed-form maximumlikelihood expressions for source strengths and noise variance at each frequency allow these parameters to be sampled implicitly, substantially reducing the dimensionality and difficulty of the inversion. This paper compares two Bayesian-point-estimation methods: the maximum a posteriori(MAP) approach and the marginal posterior probability density(PPD) approach to source localization. The MAP approach determines the sources locations by maximizing the PPD over all source and environmental parameters. The marginal PPD approach integrates the PPD over the unknowns to obtain a sequence of marginal probability distribution over source range or depth.Monte Carlo analysis of the two approaches for a test case involving both geoacoustic and water-column uncertainties indicates that:(1) For sensitive parameters such as source range, water depth and water sound speed, the MAP solution is better than the marginal PPD solution.(2) For the less sensitive parameters, such as,bottom sound speed, bottom density, bottom attenuation and water sound speed, when the SNR is low, the marginal PPD solution can better smooth the noise, which leads to better performance than the MAP solution.Since the source range and depth are sensitive parameters, the research shows that the MAP approach provides a slightly more reliable method to locate multiple sources in an unknown environment. | LI Qianqian MING Pingshou YANG Fanlin ZHANG Kai WU Ziyin | 2018 | Acta Oceanologica Sinica2018，37，6： | 1 |
| 8 | Comparative performances of new and existing indices of crown asymmetry:an evaluation using tall trees of Eucalyptus pilularis(Smith)显示文摘Over the past 50 years,crown asymmetry of forest trees has been evaluated through several indices constructed from the perspective of projected crown shape or displacement but often on an ad hoc basis to address specifi c objectives related to tree growth and competition,stand dynamics,stem form,crown structure and treefall risks.Although sharing some similarities,these indices are largely incoherent and non-comparable as they diff er not only in the scale but also in the direction of their values in indicating the degree of crown asymmetry.As the fi rst attempt at devising normative measures of crown asymmetry,we adopted a relative scale between 0 for perfect symmetry and 1 for extreme asymmetry.Five existing crown asymmetry indices(CAIs)were brought onto this relative scale after necessary modifi cations.Eight new CAIs were adapted from measures of circularity for digital images in computer graphics,indices of income inequality in economics,and a bilateral symmetry indicator in plant leaf morphology.The performances of the 13 CAIs were compared over diff erent numbers of measured crown radii for 30 projected crowns of mature Eucalyptus pilularis trees through benchmarking statistics and rank order correlation analysis.For each CAI,the index value based on the full measurement of 36 evenly spaced radii of a projected crown was taken as the true value in the benchmarking process.The index(CAI 13)adapted from the simple bilateral symmetry measure proved to be the least biased and most precise.Its performance was closely followed by that of three other CAIs.The minimum number of crown radii that is needed to provide at least an indicative measure of crown asymmetry is four.For more accurate and consistent measures,at least 6 or 8 crown radii are needed.The range of variability in crown morphology of the trees under investigation also needs to be taken into consideration.Although the CAIs are from projected crown radii,they can be readily extended to individual tree crown metrics that are now commonly extracted from LiDAR and other remotely sensed data.Adding a normative measure of crown asymmetry to individual tree crown metrics will facilitate the process of big data analytics and artifi cial intelligence in forestry wherever crown morphology is among the factors to be considered for decision making in forest management. | Fanlin Kong Huiquan Bi Michael McLean Fengri Li | 2021 | Journal of Forestry Research2021，32，1： | 1 |
| 9 | The binding epitope of sintilimab on PD-1 revealed by AbMap显示文摘PD-1 plays an important role as an immune checkpoint.Sintilimab is a newly approved PD-1 antibody for cancer immunotherapy with an unknown binding epitope on PD-1.In this study,to elucidate the molecular mechanism by which sintilimab blocks PD-1 activation,we applied Antibody binding epitope Mapping(AbMap)to identify the binding epitope of sintilimab.An epitope was successfully identified,i.e.SLAPKA,aa 127-132.By constructing a series of point mutations,the dominant residues S127,L128,A129,P130,and A132 of PD-1 were further validated by western blot analysis,biolayer interferometry,and flow cytometry.Structural analysis showed that the epitope is partially within the binding interface of PD-1 and PD-L1,and this epitope also partially overlaps with that of nivolumab and pembrolizumab.These results demonstrate that sintilimab can attenuate PD-1 activation by directly competing with the interaction between PD-1 and PD-L1 through binding with the key residues of the FG loop on PD-1.This study also demonstrates the high efficiency and accuracy of AbMap for determining the binding epitope of therapeutic antibodies. | Mingliang Ma Huan Qi Chuansheng Hu Zhaowei Xu Fanlin Wu Nan Wang Danyun Lai Yang Li Hainan Zhang Hewei Jiang Qingfeng Meng Shujuan Guo Yani Kang Xiaodong Zhao Hua Li Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 1 |
| 10 | The crucial role of lysine in the hepatic metabolism of growing Holstein dairy heifers as revealed by LC-MS-based untargeted metabolomics显示文摘The objective of this experiment was to evaluate the effect of supplementing rumen-protected Lys based on a Lys-deficient diet on liver metabolism in growing Holstein heifers.The experiment was conducted for 3 months with 36 Holstein heifers(initial body weight:200±9.0 kg;7-month-old).Heifers were randomly assigned to 2 diets based on corn,soybean meal,alfalfa hay,and wheat bran:control,Lysdeficient diet(LD;0.66%Lys in diet),and Lys-adequate diet(LA;1.00%Lys in diet).The results showed no difference in growth performance between the 2 groups(P>0.05).However,there was a clear trend of increasing feed conversion rate with Lys supplementation(0.05 | Fanlin Kong Yuan Li Qiyu Diao Yanliang Bi Yan Tu | 2021 | Animal Nutrition2021，，4： | 1 |
| 11 | A Postprocessing Method for the Removal of Refraction Artifacts in Multibeam Bathymetry Data显示文摘 | Yang Fanlin Li Jiabiao Wu Ziyin | 2007 | Marine Geodesy2007，30，3： | 1 |
| 12 | Rice3K56 is a high-quality SNP array for genome-based genetic studies and breeding in rice(Oryza sativa L.)显示文摘Single nucleotide polymorphism(SNP)genotyping arrays provide an optimal high-throughput platform for genetic research and molecular breeding programs in both animals and plants.In this study,a highquality and custom-designed Rice3K56 SNP array was developed with the resequencing data of 3024 rice accessions worldwide,which was then tested extensively in 192 representative rice samples.Printed on the Gene Titan chips of Affymetrix Axiom each containing 56,606 SNP markers,the Rice3K56 array has a high genotyping reliability(99.6%),high and uniform genome coverage(an average of 6.7-kb between adjacent SNPs),abundant polymorphic information and easy automation,compared with previously developed rice SNP arrays.When applied in rice varietal differentiation,population diversity analysis,gene mapping of 13 complex traits by a genome-wide association study analysis(GWAS),and genome selection experiments in a recombinant inbred line and a multi-parent advanced generation inter-cross populations,these properties of the Rice3K56 array were well demonstrated for its power and great potential to be a highly efficient tool for rice genetic research and genomic breeding. | Chaopu Zhang Min Li Lunping Liang Jun Xiang Fan Zhang Chenyang Zhang Yizhen Li Jing Liang Tianqing Zheng Fanlin Zhang Hua Li Binying Fu Yingyao Shi Jianlong Xu Bingchuan Tian Zhikang Li Wensheng Wang | 2023 | The Crop Journal2023，11，3： | 0 |
| 13 | Basis functions for shallow-water temperature profiles based on the internal-wave eigenmodes显示文摘The shallow-water temperature profile is typically parameterized using a few empirical orthogonal function(EOF)coefficients.However,when the experimental area is poorly known or highly variable,the adaptability of the EOFs will be significantly reduced.In this study,a new set of basis functions,generated by combining the internal-wave eigenmodes with the average temperature gradient,is developed for characterizing the temperature perturbations.Temperature profiles recorded by a thermistor chain in the South China Sea in 2015 are processed and analyzed.Compared to the EOFs,the new set of basis functions has higher reconstruction accuracy and adaptability;it is also more stable in ocean regions that have internal waves. | Qianqian Li Shoulian Cao Yu Luo Kai Zhang Fanlin Yang | 2023 | Acta Oceanologica Sinica2023，42，2： | 0 |
| 14 | An improved positioning model of deep-seafloor datum point at large incidence angle显示文摘The inhomogeneous sound speed in seawater causes refraction of sound waves,and the elimination of the refraction effect is essential to the accuracy of underwater acoustic positioning.The raytracing method is an indispensable tool for effectively handling problems.However,this method has a conflict between localization accuracy and computational quantity.The equivalent sound speed profile(ESSP)method uses a simple sound speed profile(SSP)instead of the actual complex SSP,which can improve positioning precision but with residual error.The residual error is especially non-negligible in deep water and at large beam incidence angles.By analyzing the residual error of the ESSP method through a simulation,an empirical formula of error is presented.The data collected in the sailing circle mode(large incidence angle)of the South China Sea are used for verification.The experiments show that compared to the ESSP method,the improved algorithm has higher positioning precision and is more efficient than the ray-tracing method. | Qianqian LI Shoulian CAO Fanlin YANG Yu LUO Qian TONG | 2024 | Journal of Oceanology and Limnology2024，42，1： | 0 |
| 15 | Ligation of CD180 inhibits IFN-α signaling in a Lyn-PI3K-BTK-dependent manner in B cells显示文摘全身的豺狼座 erythematosus (SLE ) 的一个特点是由汽车反应的 B 房间的各种各样的自身抗体的一致生产。Interferon-α(IFN-α) 发信号高度在 SLE B 房间被激活并且由 B 房间在抗体反应起一个重要作用。以前的研究证明了 CD180 否定的 B 房间,戏剧性地在 SLE 病人被增加,为自身抗体的生产负责。然而,在 CD180 和 IFN-α 之间的协会;未知的发信号的遗体。在现在的学习,我们在调整 IFN-α 的激活上探索了 CD180 的效果;在 B 房间发信号。我们发现 CD180 否定的 B 房间的数字在 MRL/Mp-Fas (lpr/lpr ) 被增加豺狼座容易的老鼠与野类型的老鼠相比。Phenotypic 分析证明 CD180 否定的 B 房间包括了 CD138 + plasmablast/plasma 房间和 GL-7 + 幼芽的中心(GC ) B 房间。尤其是, CD180 的结扎显著地禁止了 IFN-α信号变换器的导致的 phosphorylation 和抄写 2 的使活跃之物(STAT-2 ) 和以在 vitro 的一种 Lyn-PI3K-BTK-dependent 方式的刺激 IFN 的基因(ISG ) 的表示。而且, CD180 的结扎能也禁止 IFN-α在在 vivo 的 B 房间的导致的 ISG 表示。而且,像使用费的受体 7 并且像使用费的受体 9 发信号小径能显著地 downregulate CD180 表示并且调制在 IFN-α 的激活上发信号的 CD180 的禁止的效果;发信号。一起,我们的结果加亮在 CD180 否定的 B 房间的增加的比例和 IFN-α 的激活之间的靠近的协会;在 SLE 发信号。我们的数据提供分子的卓见进 IFN-α 的机制;在为 SLE 处理的 SLE B 房间和一条潜在的治疗学的途径的发信号的激活。 | Ming You Guanjun Dong Fanlin Li Feiya Ma Jing Ren Yujun Xu Huimin Yue Ruijing Tang Deshan Ren Yayi Hou | 2017 | Cellular & Molecular Immunology2017，14，2： | 0 |
| 16 | Repeated inoculation with rumen fluid accelerates the rumen bacterial transition with no benefit on production performance in postpartum Holstein dairy cows显示文摘Background The dairy cow’s postpartum period is characterized by dramatic physiological changes,therefore imposing severe challenges on the animal for maintaining health and milk output.The dynamics of the ruminal microbiota are also tremendous and may play a crucial role in lactation launch.We aim to investigate the potential benefits of early microbial intervention by fresh rumen microbiota transplantation(RMT)and sterile RMT in postpartum dairy cows.Twelve fistulated peak-lactation dairy cows were selected to be the donors for rumen fluid collection.Thirty postpartum cows were divided into 3 groups as the transplantation receptors respectively receiving 10 L fresh rumen fluid(FR),10 L sterile rumen fluid(SR),or 10 L saline(CON)during 3 d after calving.Results Production performance,plasma indices,plasma lipidome,ruminal microbiome,and liver transcriptome were recorded.After fresh and sterile RMT,we found that the molar proportion of propionic acid was increased on d 7 in the FR and SR groups and the bacterial composition was also significantly changed when compared with the CON group.A similarity analysis showed that the similarities between the CON group and FR or SR group on d 7 were 48.40%or 47.85%,whereas the similarities between microbiota on d 7 and 21 in the FR and SR groups were 68.34%or 66.85%.Dry matter intake and feed efficiency were not affected by treatments.Plasmaβ-hydroxybutyrate concentration in the FR group was decreased and significantly different lipids mainly included phosphatidylcholine and lysophosphatidylcholine containing polyunsaturated fatty acids.Hepatic transcriptomics analysis indicated acutephase response pathways were upregulated in the SR group.Conclusions Our study suggests that RMT can shorten the transition process of the ruminal microbiota of postpartum dairy cows with no benefit on dry matter intake or feed efficiency.Inoculation with rumen fluid may not be a useful approach to promote the recovery of postpartum dairy cows. | Fanlin Kong Feiran Wang Yijia Zhang Shuo Wang Wei Wang Shengli Li | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
| 17 | An improved algorithm based on equivalent sound velocity profile method at large incident angle显示文摘With the development of ultra-wide coverage technology,multibeam echo-sounder(MBES)system has put forward higher requirements for localization accuracy and computational efficiency of ray tracing method.The classical equivalent sound speed profile(ESSP)method replaces the measured sound velocity profile(SVP)with a simple constant gradient SVP,reducing the computational workload of beam positioning.However,in deep-sea environment,the depth measurement error of this method rapidly increases from the central beam to the edge beam.By analyzing the positioning error of the ESSP method at edge beam,it is discovered that the positioning error increases monotonically with the incident angle,and the relationship between them could be expressed by polynomial function.Therefore,an error correction algorithm based on polynomial fitting is obtained.The simulation experiment conducted on an inclined seafloor shows that the proposed algorithm exhibits comparable efficiency to the original ESSP method,while significantly improving bathymetry accuracy by nearly eight times in the edge beam. | Qianqian Li Qian Tong Fanlin Yang Qi Li Zhihao Juan Yu Luo | 2024 | Acta Oceanologica Sinica2024，43，2： | 0 |
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