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您的检索式：作者名="Felipe Curtolo"
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| 1 | 用线条对话 巴西Torta da Vila餐厅显示文摘位于圣保罗的Torta da Vila餐厅是一个小巧的家庭式餐厅,主营馅饼,面积不大,只有138 m^2,但它是这个家庭的第二家馅饼店。设计师希望能给这个位于居民区的餐厅建立全新的、易于识别的视觉和空间标识。设计团队从之前旧店铺的LOGO里面提取了绿色、灰色和馅饼符号等元素,将它们融入全新的店面设计和品牌身份之中,并且将这些标识系统化,使其可以批量化复制,为餐厅日后的扩张发展做准备。 | 秋落(编译) Manuel Sa(摄) Edson Maruyama Wanessa Simoe Luiz Felipe Curtolo Rodrigo de Moura | 2020 | 室内设计与装修2020，0，3： | 0 |
| 2 | Highly Dynamic Polynuclear Metal Cluster Revealed in a Single Metallothionein Molecule显示文摘Human metallothionein(MT)is a small-size yet efficient metal-binding protein,playing an essential role in metal homeostasis and heavy metal detoxification.MT contains two domains,each forming a polynuclear metal cluster with an exquisite hexatomic ring structure.The apoprotein is intrinsically disordered,which may strongly influence the clusters and the metal-thiolate(M-S)bonds,leading to a highly dynamic structure.However,these features are challenging to identify due to the transient nature of these species.The individual signal from dynamic conformations with different states of the cluster and M-S bond will be averaged and blurred in classic ensemble measurement.To circumvent these problems,we combined a single-molecule approach and multiscale molecular simulations to investigate the rupture mechanism and chemical stability of the metal cluster by a single MT molecule,focusing on the Zn4S11 cluster in theαdomain upon unfolding.Unusual multiple unfolding pathways and intermediates are observed for both domains,corresponding to different combinations of M-S bond rupture.None of the pathways is clearly preferred suggesting that unfolding proceeds from the distribution of protein conformational substates with similar M-S bond strengths.Simulations indicate that the metal cluster may rearrange,forming and breaking metal-thiolate bonds even when MT is folded independently of large protein backbone reconfiguration.Thus,a highly dynamic polynuclear metal cluster with multiple conformational states is revealed in MT,responsible for the binding promiscuity and diverse cellular functions of this metal-carrier protein. | Guodong Yuan Felipe Curtolo Yibing Deng Tao Wu Fang Tian Qun Ma Yutong Liu Jinglin Zuo Guilherme Menegon Arantes Peng Zheng | 2021 | Research2021，，1： | 0 |
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