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| 1 | The influence of innate and adaptative immune responses on the differential clinical outcomes of leprosy显示文摘Leprosy is a chronic infectious disease caused by Mycobacterium leprae.According to official reports from 121 countries across five WHO regions,there were 213899 newly diagnosed cases in 2014.Although leprosy affects the skin and peripheral nerves,it can present across a spectrum of clinical and histopathological forms that are strongly influenced by the immune response of the infected individuals.These forms comprise the extremes of tuberculoid leprosy(TT),with a M.leprae-specific Th1,but also a Th17,response that limits M.leprae multiplication,through to lepromatous leprosy(LL),with M.leprae-specific Th2 and T regulatory responses that do not control M.leprae replication but rather allow bacterial dissemination.The interpolar borderline clinical forms present with similar,but less extreme,immune biases.Acute inflammatory episodes,known as leprosy reactions,are complications that may occur before,during or after treatment,and cause further neurological damages that can cause irreversible chronic disabilities.This review discusses the innate and adaptive immune responses,and their interactions,that are known to affect pathogenesis and influence the clinical outcome of leprosy. | Adriana Barbosa de Lima Fonseca Marise do Vale Simon Rodrigo Anselmo Cazzaniga Tatiana Rodrigues de Moura Roque Pacheco de Almeida Malcolm S.Duthie Steven G.Reed Amelia Ribeiro de Jesus | 2017 | Infectious Diseases of Poverty2017，6，1： | 2 |
| 2 | COL1A1 Sp1-binding site polymorphism as a risk factor for genital prolapse显示文摘 | Andrea Moura Rodrigues Manoel Jo?o Batista Castello Gir?o Ismael Dale Cotrim Guerreiro Silva Marair Gracio Ferreira Sartori Karina de Falco Martins Rodrigo de Aquino Castro | 2008 | International Urogynecology Journal2008，，11： | 1 |
| 3 | SJES14110700184569显示文摘 | Di?go P. Bezerra Francisco W.M. da Silva Pedro A.S. de Moura Allyson G.S. Sousa Rodrigo S. Vieira Enrique Rodriguez-Castellon Diana C.S. Azevedo | 2014 | Applied Surface Science2014，，： | 1 |
| 4 | Sodium picosulphate or polyethylene glycol before elective colonoscopy in outpatients?A systematic review and meta-analysis显示文摘AIM To determine the best option for bowel preparation [sodium picosulphate or polyethylene glycol(PEG)] for elective colonoscopy in adult outpatients.METHODS A systematic review of the literature following the PRISMA guidelines was performed using Medline, Scopus, EMBASE, Central, Cinahl and Lilacs. No restrictions were placed for country, year of publication or language. The last search in the literature was performed on November 20th, 2017. Only randomized clinical trials with full texts published were included. The subjects included were adult outpatients who underwent bowel cleansing for elective colonoscopy. The included studies compared sodium picosulphate with magnesium citrate(SPMC)and PEG for bowel preparation. Exclusion criteria were the inclusion of inpatients or groups with specific conditions, failure to mention patient status(outpatient or inpatient) or dietary restrictions, and permission to have unrestricted diet on the day prior to the exam. Primary outcomes were bowel cleaning success and/or tolerability of colon preparation. Secondary outcomes were adverse events, polyp and adenoma detection rates. Data on intention-totreat were extracted by two independent authors and risk of bias assessed through the Jadad scale. Funnel plots, Egger's test, Higgins' test(I2) and sensitivity analyses were used to assess reporting bias and heterogeneity. The meta-analysis was performed by computing risk difference(RD) using MantelHaenszel(MH) method with fixed-effects(FE) and random-effects(RE) models.Review Manager 5(RevMan 5) version 6.1(The Cochrane Collaboration) was the software chosen to perform the meta-analysis.RESULTS662 records were identified but only 16 trials with 6200 subjects were included for the meta-analysis. High heterogeneity among studies was found and sensitivity analysis was needed and performed to interpret data. In the pooled analysis,SPMC was better for bowel cleaning [MH FE, RD 0.03, IC(0.01, 0.05), P = 0.003, I2= 33%, NNT 34], for tolerability [MH RE, RD 0.08, IC(0.03, 0.13), P = 0.002, I2 =88%, NNT 13] and for adverse events [MH RE, RD 0.13, IC(0.05, 0.22), P = 0.002,I2 = 88%, NNT 7]. There was no difference in regard to polyp and adenoma detection rates. Additional analyses were made by subgroups(type of regimen,volume of PEG solution and dietary recommendations). SPMC demonstrated better tolerability levels when compared to PEG in the following subgroups:'day-before preparation' [MH FE, RD 0.17, IC(0.13, 0.21), P < 0.0001, I2 = 0%,NNT 6], 'preparation in accordance with time interval for colonoscopy' [MH RE,RD 0.08, IC(0.01, 0.15), P = 0.02, I2 = 54%, NNT 13], when compared to 'highvolume PEG solutions' [MH RE, RD 0.08, IC(0.01, 0.14), I2 = 89%, P = 0.02, NNT13] and in the subgroup 'liquid diet on day before' [MH RE, RD 0.14, IC(0.06,0.22), P = 0.0006, I2 = 81%, NNT 8]. SPMC was also found to cause fewer adverse events than PEG in the 'high-volume PEG solutions' [MH RE, RD-0.18,IC(-0.30,-0.07), P = 0.002, I2 = 79%, NNT 6] and PEG in the 'low-residue diet'subgroup [MH RE, RD-0.17, IC(-0.27, 0.07), P = 0.0008, I2 = 86%, NNT 6].CONCLUSION SPMC seems to be better than PEG for bowel preparation, with a similar bowel cleaning success rate, better tolerability and lower prevalence of adverse events. | Rodrigo Silva de Paula Rocha Igor Braga Ribeiro Diogo Turiani Hourneaux de Moura Wanderley Marques Bernardo Maurício Kazuyoshi Minata Flávio Hiroshi Ananias Morita Júlio Cesar Martins Aquino Elisa Ryoka Baba Nelson Tomio Miyajima Eduardo Guimaraes Hourneaux de Moura | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，12： | 1 |
| 5 | Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy显示文摘 | Leonardo A. Calderon Juliana C. Sobrinho Kayena D. Zaqueo Andrea A. de Moura Amy N. Grabner Maurício V. Mazzi Silvana Marcussi Auro Nomizo Carla F. C. Fernandes Juliana P. Zuliani Bruna M. A. Carvalho Saulo L. da Silva Rodrigo G. Stábeli Andreimar M. Soar | 2014 | BioMed Research International2014，，： | 1 |
| 6 | Real-world treatment patterns and disease control over one year in patients with inflammatory bowel disease in Brazil显示文摘BACKGROUND Crohn’s disease(CD)and ulcerative colitis(UC)are inflammatory bowel diseases(IBDs)with a remission-relapsing presentation and symptomatic exacerbations that have detrimental impacts on patient quality of life and are associated with a high cost burden,especially in patients with moderate-to-severe disease.The Real-world Data of Moderate-to-Severe Inflammatory Bowel Disease in Brazil(RISE BR)study was a noninterventional study designed to evaluate disease control,treatment patterns,disease burden and health-related quality of life in patients with moderate-to-severe active IBD.We report findings from the prospective follow-up phase of the RISE BR study in patients with active UC or CD.AIM To describe the 12-mo disease evolution and treatment patterns among patients with active moderate-to-severe IBD in Brazil.METHODS This was a prospective,noninterventional study of adult patients with active Crohn’s disease(CD:Harvey-Bradshaw Index≥8,CD Activity Index≥220),inadequate CD control(i.e.,calprotectin>200μg/g or colonoscopy previous results),or active ulcerative colitis(UC:Partial Mayo score≥5).Enrollment occurred in 14 centers from October 2016 to February 2017.The proportion of active IBD patients after 9-12 mo of follow-up,Kaplan-Meier estimates of the time to mild or no activity and a summary of treatment initiation,discontinuation and dose changes were examined.RESULTS The study included 118 CD and 36 UC patients,with mean±SD ages of 43.3±12.6 and 44.9±16.5 years,respectively.The most frequent drug classes at index were biologics for CD(62.7%)and 5-aminosalicylate derivates for UC patients(91.7%).During follow-up,65.3%of CD and 86.1%of UC patients initiated a new treatment at least once.Discontinuations/dose changes occurred in 68.1%of CD patients[median 2.0(IQR:2-5)]and 94.3%of UC patients[median 4.0(IQR:3-7)].On average,CD and UC patients had 4.4±2.6 and 5.0±3.3 outpatient visits,respectively.The median time to first mild or no activity was 319(IQR:239-358)d for CD and 320(IQR:288-358)d for UC patients.At 9-12 mo,22.0%of CD and 20.0%of UC patients had active disease.CONCLUSION Although a marked proportion of active IBD patients achieved disease control within one year,the considerable time to achieve this outcome represents an unmet medical need of the current standard of care in a Brazilian real-world setting. | Ligia Yukie Sassaki Sender J Miszputen Roberto Luiz Kaiser Junior Wilson R Catapani Mauro Bafutto António S Scotton Cyrla Zaltman Julio Pinheiro Baima Hagata S Ramos Mikaell Alexandre Gouvea Faria Carolina D Gonçalves Isabella Miranda Guimaraes Cristina Flores Heda M B S Amarante Rodrigo Bremer Nones JoséMiguel Luz Parente Murilo Moura Lima Júlio Maria Chebli Maria de Lourdes Abreu Ferrari Julia F Campos Maria G P Sanna Odery Ramos Rogério Serafim Parra Jose J R da Rocha Omar Feres Marley R Feitosa Rosana Fusaro Caratin Juliana Tosta Senra Genoile Oliveira Santana | 2021 | World Journal of Gastroenterology2021，27，23： | 0 |
| 7 | Study and Evaluation of Aluminum Capsules to Irradiation of Gaseous Samples in Nuclear Reactor显示文摘 | Osvaldo Luiz da Costa Anselmo Feher Joao A. Moura Carla D. Souza Rodrigo Tiezzi Daiane C. B. de Souza Eduardo S. Moura Henrique B. Oliveira Carlos A. Zeituni Maria Elisa C. M. Rostelato | 2015 | Journal of Physical Science and Application2015，5，4： | 0 |
| 8 | Strategy for Controlling the Level in a Dissolved Air Flotation Chamber显示文摘 | Rodrigo Almeida Galdino Alex Elton de Moura Valdemir Alexandre dos Santos Leonie Asfora Sarubbo | 2015 | Journal of Chemistry and Chemical Engineering2015，9，5： | 0 |
| 9 | 用线条对话 巴西Torta da Vila餐厅显示文摘位于圣保罗的Torta da Vila餐厅是一个小巧的家庭式餐厅,主营馅饼,面积不大,只有138 m^2,但它是这个家庭的第二家馅饼店。设计师希望能给这个位于居民区的餐厅建立全新的、易于识别的视觉和空间标识。设计团队从之前旧店铺的LOGO里面提取了绿色、灰色和馅饼符号等元素,将它们融入全新的店面设计和品牌身份之中,并且将这些标识系统化,使其可以批量化复制,为餐厅日后的扩张发展做准备。 | 秋落(编译) Manuel Sa(摄) Edson Maruyama Wanessa Simoe Luiz Felipe Curtolo Rodrigo de Moura | 2020 | 室内设计与装修2020，0，3： | 0 |
| 10 | 决定巴西Espinhaco生物圈保护区森林-草地变化的环境因素显示文摘关于热带雨林(对火敏感)和开放地层(耐火)之间边界所涉及过程的认识对于保护生物多样性和生态系统服务至关重要,尤其是在气候变化和人为压力增加的情况下。本文调查了位于巴西东南部的Espinhaco生物圈保护区内的森林岛屿和湿润草原同时出现的主要环境因素。我们使用Costa(2018)布置的永久样地来收集森林岛屿的土壤变量(水分和化学性质)。对于湿润草原的采样,我们从岛屿边缘沿不同方向设置了4条30m的线。随后,我们在每条线上划了3个点,每个点相距10m,每个区域共12个点。我们还调查了处理火烧前后的植被覆盖情况,并对环境变量进行均值检验和主成分分析。研究结果显示,森林岛屿土壤中钾、盐基总量、阳离子交换容量和有机质的值均高于湿润草地。因此,两种植被类型之间的边界定义似乎主要与土壤肥力和水分梯度有关。在对这些地区进行火烧处理后,在岛屿边缘附近没有发现树木个体的再生。因此,这些研究结果表明,由于明确的土壤气候条件,森林岛屿无法扩张。因此,这些环境应该成为设计公共保护政策的目标焦点,因为它们增加了山地岩石草原植被景观的复杂性。 | Thais Ribeiro Costa Cristiane Coelho de Moura Leovandes Soares da Silva Anne Priscila Dias Gonzaga AndréRodrigo Rech Evandro Luiz Mendonga Machado | 2023 | Journal of Plant Ecology2023，16，5： | 0 |
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