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| 1 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | How does high-intensity intermittent training affect recreational endurance runners? Acute and chronic adaptations: A systematic review显示文摘Objective: This systematic review aimed to critically analyze the literature to determine how high-intensity intermittent training(HIIT) affects recreational endurance runners in the short-and long-term.Methods: Electronic databases were searched for literature dating from January 2000 to October 2015. The search was conducted using the key words 'high-intensity intermittent training' or 'high-intensity interval exercise' or 'interval running' or 'sprint interval training' and 'endurance runners' or 'long distance runners'. A systematic approach was used to evaluate the 783 articles identified for initial review. Studies were included if they investigated HIIT in recreational endurance runners. The methodological quality of the studies was evaluated using the Physiotherapy Evidence Database(PEDro) scale(for intervention studies) and the modified Downs and Black Quality Index(for cross-sectional studies).Results: Twenty-three studies met the inclusionary criteria for review. The results are presented in 2 parts: cross-sectional(n = 15) and intervention studies(n = 8). In the 15 cross-sectional studies selected, endurance runners performed at least 1 HIIT protocol, and the acute impact on physiological, neuromuscular, metabolic and/or biomechanical variables was assessed. Intervention studies lasted a minimum of 4 weeks, with 10 weeks being the longest intervention period, and included 2 to 4 HIIT sessions per week. Most of these studies combined HIIT sessions with continuous run(CR) sessions; 2 studies' subjects performed HIIT exclusively.Conclusion: HIIT-based running plans(2 to 3 HIIT sessions per week, combining HIIT and CR runs) show athletic performance improvements in endurance runners by improving maximal oxygen uptake and running economy along with muscular and metabolic adaptations. To maximize the adaptations to training, both HIIT and CR must be part of training programs for endurance runners. | Felipe García-Pinillos Víctor M.Soto-Hermoso Pedro A.Latorre-Román | 2017 | Journal of Sport and Health Science2017，6，1： | 2 |
| 4 | Coronary physiology assessment in the catheterization laboratory显示文摘Physicians cannot rely solely on the angiographic appearance of epicardial coronary artery stenosis when evaluating patients with myocardial ischemia. Instead, sound knowledge of coronary vascular physiology and of the methods currently available for its characterization can improve the diagnostic and prognostic accuracy of invasive assessment of the coronary circulation, and help improve clinical decision-making. In this article we summarize the current methods available for a thorough assessment of coronary physiology. | Felipe Díez-delhoyo Enrique Gutiérrez-Ibanes Gerard Loughlin Ricardo Sanz-Ruiz María Eugenia Vázquez-álvarez Fernando Sarnago-Cebada Rocío Angulo-Llanos Ana Casado-Plasencia Jaime Elízaga Francisco Fernández Avilés Diáz | 2015 | World Journal of Cardiology2015，7，9： | 2 |
| 5 | Effects of 12 weeks of barefoot running on foot strike patterns,inversion-eversion and foot rotation in long-distance runners显示文摘Purpose:The purpose of this study was to determine the effects of 12 weeks of barefoot running on foot strike patterns,inversion-eversion and foot rotation in long-distance runners.Methods:Thirty-one endurance runners with no experience in barefoot running were randomized into a control group and an experimental group who received barefoot training.At pre-test and post-test,all subjects ran at low and high self-selected speeds on a treadmill.Data were collected by systematic observation of lateral and back recordings at 240 Hz.Results:McNemar’s test indicated significant changes(p <0.05) in the experimental group at both high and low speed running in foot strike patterns,reducing the percentage of high rearfoot strikers and increasing the number of midfoot strikers.A significant increase(p <0.05) of external rotation of the foot and a decrease of inversion occurred at comfortable speed in the experimental group.Conclusion:Twelve weeks of barefoot running,applied progressively,causes significant changes in foot strike pattern with a tendency toward midfoot or forefoot strikes,regardless of running speed and significant changes in foot rotation at low speed,while the inversion was reduced in left foot at low speed with a tendency toward centered strike. | Pedro ALatorre-Román Felipe García-Pinillos Víctor M.Soto-Hermoso Marcos Munoz-Jiménez | 2019 | Journal of Sport and Health Science2019，8，6： | 2 |
| 6 | Mature results of PulmonArt:Involved-field 3D radiotherapy(RT)and docetaxel/ cisplatin chemotherapy(CT)in a randomised phase 2 study comparing concurrent CT-RT followed by consolidation CT, with induction CT followed by concurrent CT-RT in patients(pts)with stage III non-small cell lung cancer(NSCLC): B5-06 显示文摘 | van Meerbeeck JP Felipe C Johan V | 2007 | J Thorac Oncol2007，2，8： | 1 |
| 7 | A simple description of age-related changes in crystalline lens thickness显示文摘 | Garcia-Domene MC Díez-Ajenjo MA Gracin V Felipe A Artigas JM | | 0，，05： | 1 |
| 8 | Transesterifica- tion of Vegetable Oils:Simulating the Replacement of Batch Reactors with Continuous Reactors 显示文摘 | Felipe A S F Jose A V Sergio P R | 2010 | Bioresource Technology2010，101，： | 1 |
| 9 | Effects of dietary live yeast Debaryomyces hansenii on the im- mune and antioxidant system in juvenile leopard grouper Mycteroperca rosacea exposed to stress 显示文摘 | Martha R B Dariel T R Felipe A V | 2008 | Aquaculture2008，280，14： | 1 |
| 10 | Corporate so-cial responsibility, firm value and financial performance inBrazil显示文摘 | VICENTE L C FREIRE F S FELIPE C V | 2011 | Social Responsibility Journal2011，7，2： | 1 |
| 11 | Cancer gene therapy by thyroid hormone-mediated expression of toxin genes显示文摘 | Martin V Cortes ML de Felipe P | 2000 | Cancer Res2000，60，12： | 1 |
| 12 | Role of glycerol addition on xylose-to-xylitol bioconversion by Candida guiUiermondii 显示文摘 | Arruda P V Felipe M G | 2009 | Current Microbiology2009，58，3： | 1 |
| 13 | Jasmonate modulates development and light-regulated alkaloid biosynthesis in Catharanthus Roseus显示文摘 | Flotaand V Felipe A | 1998 | Phytochem1998，49，2： | 1 |
| 14 | Cancer gene therapy by thyroid hormone-mediated expression of toxin genes显示文摘 | Martin V Cortes ML de Felipe P el al | 2000 | CancerRes2000，60，12： | 1 |
| 15 | Growth, feed efficiency and condition of common Octopus fed two formulated moist diets显示文摘 | Jesus C V Maria D H Felipe A G | 2008 | Aquaculture2008，275，： | 1 |
| 16 | Successful use of a plant gene in the treatment of cancer in vivo显示文摘 | Cortes ML de Felip P Martin V | 1998 | Gene Therapy1998，5，11： | 1 |
| 17 | Private sector participate on in the delivery of highway infrastructure in Central America and Mexico显示文摘 | Felipe V Stephen A | 2004 | Construction Management and Economics2004，22，： | 1 |
| 18 | Monitoring and modeling water-vegetation interactions in groundwater-dependent ecosystems显示文摘 | Felipe O Parikshit V Steven P | 2012 | Reviews of Geophysics2012，50，3： | 1 |
| 19 | Site-specific release of nascent chains from ribosomes at a sense codon显示文摘 | Doronina V A Wu C de Felipe P | | 0，，13： | 1 |
| 20 | Analysis and functionaL annotation of an expressed sequence tag collection for tropical crop sugarcane显示文摘 | ANDPE L V FELIPE R S EDSON L K et at | 2003 | Genome Res2003，13，： | 1 |
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