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| 1 | Evidence to suggest adoption of water exchange deservesbroader consideration:Its pain alleviating impact occurs in90%of investigators显示文摘AIM: To determine variations in colonoscopy real-time insertion pain among investigators using three different insertion techniques.METHODS: From March 2013 through June 2014, 18-85-year-old diagnostic and 50-70-year-old screening patients were enrolled at each center to on-demand sedation colonoscopy with water exchange(WE), water immersion(WI) and insufflation with air or CO2 for insertion and withdrawal [air or carbon dioxide(AICD)]. Data were aggregated for analysis. Primary outcome: Variations in real-time maximum insertion pain(0 = none, 1-2 = discomfort, 10 = worst).RESULTS: One thousand and ninety-one cases analyzed: WE(n = 371); WI(n = 338); AICD(n = 382). Demographics and indications were comparable. The WE group had the lowest real-time maximum insertion pain score, mean(95%CI): WE 2.8(2.6-3.0), WI 3.8(3.5-4.1) and AICD 4.4(4.1-4.7), P < 0.0005. Ninety percent of the colonoscopists were able to use water exchange to significantly decrease maximum insertion pain scores. One investigator had high insertion pain in all groups, nonetheless WE achieved the lowest real-time maximum insertion pain score. WE had the highest proportions of patients with painless unsedated colonoscopy(vs WI, P = 0.013; vs AICD, P < 0.0005); unsedated colonoscopy with only minor discomfort(vs AICD, P < 0.0005), and completion without sedation(vs AICD, P < 0.0005).CONCLUSION: Aggregate data confirm superiority of WE in lowering colonoscopy real-time maximum insertion pain and need for sedation. Ninety percent of investigators were able to use water exchange to significantly decrease maximum insertion pain scores. Our results suggest that the technique deserves consideration in a broader scale. | Sergio Cadoni Mauro Liggi Premysl Falt Stefano Sanna Mariangela Argiolas Viviana Fanari Paolo Gallittu Donatella Mura Maria L Porcedda Vit Smajstrla Matteo Erriu Felix W Leung | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 2 |
| 2 | the proto-oneogene c-kit is expressed in leiomyo sarcomas of the uterus显示文摘 | Wang L Felix JJC Lee JI | 2003 | Gynecol Oncol2003，90，3： | 1 |
| 3 | Parallcl ization of the Scatter Search for the p median Problem 显示文摘 | FELIX G L BELEN M B JOSE A M P | 2003 | Parallel Computing2003，29，5： | 1 |
| 4 | Environmental impact and management of phosphogypsum 显示文摘 | Hanan T Mohamed C Felix A L | 2009 | Journal of Environmental Man- agement2009，90，8： | 1 |
| 5 | Uphill permeation of Cr(Ⅵ) using Hostarex A327 as ionophore by membrane-solvent extraction processing显示文摘 | Francisco J A Manuel A Felix L | 2008 | Chemosphere2008，72，： | 1 |
| 6 | The successful treatment of lupus pemio with the flashlamp pulsed dye laser 显示文摘 | Cliff S Felix RH Singh L | 1999 | J Cutan Laser Ther1999，1，1： | 1 |
| 7 | Synthesis of Nickel-chronium-zinc Powders from Stainless Steel Pickling Liquor显示文摘 | Auroru LD Felix A L | 1999 | J Mater Res1999，14，8： | 1 |
| 8 | A single locus determines sensitivity to bacterial flagellin in Arabidopsis thaliana显示文摘 | GOMEZ-GOMEZ L FELIX G BOLLER T | | 0，，： | 1 |
| 9 | Development and Validation of a Deep Learning Based Automated Minirhizotron Image Analysis Pipeline显示文摘Root systems of crops play a significant role in agroecosystems.The root system is essential for water and nutrient uptake,plant stability,symbiosis with microbes,and a good soil structure.Minirhizotrons have shown to be effective to noninvasively investigate the root system.Root traits,like root length,can therefore be obtained throughout the crop growing season. | Felix Maximilian Bauer Lena Lärm Shehan Morandage Guillaume Lobet Jan Vanderborght Harry Vereecken Andrea Schnepf | 2022 | Plant Phenomics2022，4，1： | 1 |
| 10 | Structural models and endogeneity in corporate finance:The link between managerial ownership and corporate performance显示文摘 | Coles Jeffrey L Lemmon Michael L &Felix Meschke J | 2012 | Journal of Financial Economics2012，103，1： | 1 |
| 11 | Faecal calprotectin and magnetic resonance imaging in detecting Crohn's disease endoscopic postoperative recurrence显示文摘AIM To assess magnetic resonance imaging(MRI) and faecal calprotectin to detect endoscopic postoperative recurrence in patients with Crohn's disease(CD).METHODS From two tertiary centers, all patients with CD who underwent ileocolonic resection were consecutively and prospectively included. All the patients underwent MRI and endoscopy within the first year after surgery or after the restoration of intestinal continuity [median = 6 mo(5.0-9.3)]. The stools were collected the day before the colonoscopy to evaluate faecal calprotectin level. Endoscopic postoperative recurrence(POR) was defined as Rutgeerts' index ≥ i2b. The MRI was analyzed independently by two radiologists blinded from clinical data.RESULTS Apparent diffusion coefficient(ADC) was lower in patients with endoscopic POR compared to those with no recurrence(2.03 ± 0.32 vs 2.27 ± 0.38 × 10^(-3) mm^2/s, P = 0.032). Clermont score(10.4 ± 5.8 vs 7.4 ± 4.5, P = 0.038) and relative contrast enhancement(RCE)(129.4% ± 62.8% vs 76.4% ± 32.6%, P = 0.007) were significantly associated with endoscopic POR contrary to the magnetic resonance index of activity(Ma RIA)(7.3 ± 4.5 vs 4.8 ± 3.7; P = 0.15) and MR scoring system(P = 0.056). ADC < 2.35 × 10^(-3) mm^2/s [sensitivity = 0.85, specificity = 0.65, positive predictive value(PPV) = 0.85, negative predictive value(NPV) = 0.65] and RCE > 100%(sensitivity = 0.75, specificity = 0.81, PPV = 0.75, NPV = 0.81) were the best cutoff values to identify endoscopic POR. Clermont score > 6.4(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74), Ma RIA > 3.76(sensitivity = 0.61, specificity = 0.82, PPV = 0.73, NPV = 0.74) and a MR scoring system ≥ MR1(sensitivity = 0.54, specificity = 0.82, PPV = 0.70, and NPV = 0.70) demonstrated interesting performances to detect endoscopic POR. Faecal calprotectin values were significantly higher in patients with endoscopic POR(114 ± 54.5 μg/g vs 354.8 ± 432.5 μg/g; P = 0.0075). Faecal calprotectin > 100 μg/g demonstrated high performances to detect endoscopic POR(sensitivity = 0.67, specificity = 0.93, PPV = 0.89 and NPV = 0.77).CONCLUSION Faecal calprotectin and MRI are two reliable tools to detect endoscopic POR in patients with CD. | Pierre Baillet Guillaume Cadiot Marion Goutte Felix Goutorbe Hedia Brixi Christine Hoeffel Christophe Allimant Maud Reymond Hélène Obritin-Guilhen Benoit Magnin Gilles Bommelaer Bruno Pereira Constance Hordonneau Anthony Buisson | 2018 | World Journal of Gastroenterology2018，24，5： | 1 |
| 12 | CAS Lib 显示文摘 | Sachetto-Martins G Fernandes L D Felix D | 1995 | Int J Plant Sci1995，156，： | 1 |
| 13 | A Double-Difference Earthquake Location Algorithm: Method and Application to the northern Hayward fault, California显示文摘 | Felix Waldhauser and William L Ellsworth | 2000 | Bulletin of the Seismological Society of America2000，90，： | 1 |
| 14 | Comparison of accelerated solvent extraction with conventional solvent extraction for organophosphorus pesticides and herbicides显示文摘 | Ezzell J L Richter B E Felix W D | 1995 | LC/GC1995，13，5： | 1 |
| 15 | Adding sodium bicarborate to lidocaine enhances the depth of epidural blockade 显示文摘 | Curatolo M Petersen - felix S Arendt - Nielsen L | 1998 | Anesth Analg1998，86，： | 1 |
| 16 | The proto-oncogene c-kit is expressed in leiomyosarcomas of the uterus显示文摘 | Wang L Felix J JC Lee JL | 2003 | Gynecol Oncol2003，90，2： | 1 |
| 17 | A Double-Difference Earthquake Location Algorithm: Method and Application to the Northern Hayward Fault,California显示文摘 | Felix Waldhauser William L Ellsworth | 2000 | Bull Seismol Soc Amer2000，90，6： | 1 |
| 18 | Identification of micrometastases in histologically negative lymph nodes of earlystage cervical cancer patients显示文摘 | Lentz S E Muderspach L I Felix J C | 2004 | Obstet Gyneco2004，103，6： | 1 |
| 19 | Maintenance strategy based on a multicriterion classification of equipments 显示文摘 | C G L H Felix J R C Jose | 2006 | Reliability Engineering and System Safety2006，，91： | 1 |
| 20 | Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease显示文摘 | Fabian C. Franzeck Danielle Hof Remo D. Spescha Matthias Hasun Alexander Akhmedov Jan Steffel Yi Shi Francesco Cosentino Felix C. Tanner Arnold von Eckardstein Willibald Maier Thomas F. Lüscher Christophe A. Wyss Giovanni G. Camici | 2011 | Atherosclerosis2011，，1： | 1 |
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