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| 1 | Dissecting the role of AMP-activated protein kinase in human diseases显示文摘AMP-activated protein kinase(AMPK), known as a sensor and a master of cellular energy balance, integrates various regulatory signals including anabolic and catabolic metabolic processes.Accompanying the application of genetic methods and a plethora of AMPK agonists, rapid progress has identified AMPK as an attractive therapeutic target for several human diseases, such as cancer, type2 diabetes, atherosclerosis, myocardial ischemia/reperfusion injury and neurodegenerative disease. The role of AMPK in metabolic and energetic modulation both at the intracellular and whole body levels has been reviewed elsewhere. In the present review, we summarize and update the paradoxical role of AMPK implicated in the diseases mentioned above and put forward the challenge encountered. Thus it will be expected to provide important clues for exploring rational methods of intervention in human diseases. | Jin Li Liping Zhong Fengzhong Wang Haibo Zhu | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 18 |
| 2 | Effects of dietary fiber on human health显示文摘Dietary fiber(DF)is believed to provide important health benefits and it has become a research hotspot.DF exists in most natural foods,including fruits(16.74%-91.24%),vegetables(6.53%-85.19%),grains(9.76%-69.20%)and so on.DF has different physicochemical properties such as water holding capacity(WHC)(2.01-25.03 g/g),water swelling capacity(WSC)(0.95-23.90 mL/g),oil holding capacity(OHC)(0.65-29.00 g/g),glucose adsorption capacity(GAC)(0.17-4.65 mmol/g),cholesterol adsorption capacity(CAC)(0.03-37.10 mg/g)and viscosity,which make it exhibits different physiological functions such as reducing the risk of obesity,diabetes,cancer,and intestinal diseases.On the basis of consulting related databases,the physicochemical properties of DF and its derived physiological functions are reviewed.It is found that DF has effect on the prevention and treatment of obesity due to good WHC,WSC,OHC and CAC.Good GAC can relieve the symptoms of diabetes.The physicochemical properties of WHC and WSC can reduce the risk of cancer.The WHC,WSC and viscosity are beneficial to intestinal health. | Yang He Bixiang Wang Liankui Wen Fengzhong Wang Hansong Yu Dongxia Chen Xin Su Chi Zhang | 2022 | Food Science and Human Wellness2022，11，1： | 15 |
| 3 | Experimental Research on Resistance Characteristics of H-type Elliptical Finned Tube Bundles显示文摘阻力特性是换热器的基本特性之一,流体横掠换热管产生的绕流扰动是换热器阻力恶化的主要因素。为分析前排绕流对后排阻力的影响规律,分别对管排数2-10不等的换热管进行阻力特性试验研究,同时为定量分析管排数对阻力特性的影响规律,定义了管排阻力修正系数,并根据实验数据给出了其在不同管排数下的取值,具有重要的工程意义;同时基于冷态阻力特性试验台进行实验研究,得到κ=1及κ=1.6的经典椭圆管的阻力特性公式Eu,并研究不同管型及布置方式对其的影响规律。 | LI Fei SHI Yuetao SUN Fengzhong | 2013 | 中国电机工程学报2013，33，32： | 7 |
| 4 | Global practical tracking with prescribed transient performance for inherently nonlinear systems with extremely severe uncertainties显示文摘This paper considers the global practical tracking for a class of uncertain nonlinear systems. Remarkably, the systems under investigation admit rather inherent nonlinearities, and especially allow arguably the most severe uncertainties: unknown control directions and non-parametric uncertainties. Despite this,a refined tracking objective, rather than a reduced one, is sought. That is, not only pre-specified arbitrary tracking accuracy is guaranteed, but also certain prescribed transient performance(e.g., arrival time and maximum overshoot) is ensured to better meet real applications. To solve the problem, a new tracking scheme is established, crucially introducing delicate time-varying gains to counteract the severe uncertainties and guarantee the prescribed performance. It is shown that the designed controller renders the tracking error to forever evolve within a prescribed performance funnel, through which the desired tracking objective is accomplished for the systems. Particularly, by subtly specifying the funnel, global fixed-time practical tracking(i.e., that with prescribed arrival time) and semiglobal practical tracking with prescribed maximal overshoot can be achieved for the systems. Moreover, the tracking scheme remains valid in the presence of rather less-restrictive unmodeled dynamics. | Fengzhong LI Yungang LIU | 2019 | Science China(Information Sciences)2019，62，2： | 4 |
| 5 | A Survey of Ranging Algorithms and Localization Schemes in Underwater Acoustic Sensor Network显示文摘Underwater Acoustic Sensor Network(UASN) has attracted significant attention because of its great influence on ocean exploration and monitoring. On account of the unique characteristics of underwater environment, localization, as one of the fundamental tasks in UASNs, is a more challenging work than in terrestrial sensor networks. A survey of the ranging algorithms and the network architectures varied with different applications in UASNs is provided in this paper. Algorithms used to estimate the coordinates of the UASNs nodes are classified into two categories: rangebased and range-free. In addition, we analyze the architectures of UASNs based on different applications, and compare their performances from the aspects of communication cost, accuracy, coverage and so on. Open research issues which would affect the accuracy of localization are also discussed, including MAC protocols, sound speed and time synchronization. | QU Fengzhong WANG Shiyuan WU Zhihui LIU Zubin | 2016 | China Communications2016，13，3： | 4 |
| 6 | Advances in Researches on Chemical Composition and Functions of Hemerocallis Plants显示文摘The genus Hemerocallis is a kind of perennial herbaceous plants of Liliaceae and consists of about 15 species in the world,11 of which can be found in China. Some species of Hemerocallis are widely cultivated for medicinal,edible and ornamental application. Considerable progress had been made in researches on chemical composition and functions of Hemerocallis plants. Previous phytochemical studies on Hemerocallis plants have demonstrated the presence of flavonoids,anthraquinones,alkaloids,terpenoids,triterpenes and triterpenoid saponins,caffeoylquinic acid derivatives,naphthalene glycosides,steroid and steroidal saponins,phenylethanoid glycosides,and lignans. Functional activities of Hemerocallis plants are mainly manifested in sedative hypnotic,antidepressant,antioxidant,anti-tumor,hepatoprotective,antibacterial and insecticidal activities. Chemical composition of Hemerocallis plants is various,and structural type is rich,and has a variety of significant functional activities,so it is worth further study. | Yan WANG Teng XU Bei FAN Lijing ZHANG Cong LU Donghui WANG Xinmin LIU Fengzhong WANG | 2018 | Medicinal Plant2018，9，2： | 2 |
| 7 | Structural analysis of receptor-like kinase SOBIR1 reveals mechanisms that regulate its phosphorylation-dependent activation显示文摘Plant leucine-rich repeat(LRR)receptor-like kinases(RLKs)and LRR receptor-like proteins(RLPs)comprise a large family of cell surface receptors that play critical roles in signal perception and transduction.Both LRR-RLKs and LRR-RLPs rely on regulatory LRR-RLKs to initiate downstream signaling pathways.BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1/SOMATIC EMBRYOGENESIS RECEPTOR KINASE 3(BAK1/SERK3)and SUPPRESSOR OF BIR1-1(SOBIR1)are important and extensively studied regulatory LRR-RLKs with distinct functions.Although the regulatory mechanism of BAK1 activation has been studied in detail,the activation mechanism of SOBIR1 remains poorly understood.Here,the crystal structures of the catalytically inactive kinase domain of SOBIR1(SOBIR1-KD)from Arabidopsis thaliana were determined in complexes with AMP-PNP and Mg^(2+).The results show that SOBIR1-KD contains a uniquely long β3-αC loop and adopts an Src-like inactive conformation with an unusual architecture at the activation segment,which comprises three helices.Biochemical studies revealed that SOBIR1 is transphosphorylated by BAK1 following its autophosphorylation via an intermolecular mechanism,and the phosphorylation of Thr529 in the activation segment and the β3-αC loop are critical for SOBIR1 phosphorylation.Further functional analysis confirmed the importance of Thr529 and the β3-αC loop for the SOBIR1-induced cell death response in Nicotiana benthamiana.Taken together,these findings provide a structural basis for the regulatory mechanism of SOBIR1 and reveal the important elements and phosphorylation events in the special stepwise activation of SOBIR1-KD,the first such processes found in regulatory LRR-RLKs. | Xue Wei Yulu Wang Su Zhang Tianyi Gu Gabryel Steinmetz Haiyan Yu Guoguang Guo Xin Liu Shilong Fan Fengzhong Wang Yangnan Gu Fengjiao Xin | 2022 | Plant Communications2022，3，2： | 2 |
| 8 | Gravity model in the Korean highway显示文摘 | Woo-Sung Jung Fengzhong Wang H. Eugene Stanley | 2008 | EPL (Europhysics Letters)2008，，4： | 2 |
| 9 | Total Focusing Method Damage Imaging in Frequency Domain Using Laser-Ultrasonic Lamb Wave Based on Time-domain Filtering in Multi-band显示文摘A fully non-contact experimental platform for ultrasonic Lamb wave damage detection was constructed,where laser exciting and the scanning laser Doppler vibrometer were used to realize the high-resolution pickup of the Lamb wave field in the structure,which has overcome the disadvantages of low spatial resolution caused by the conventional contact Lamb wave transducer.In order to suppress the dispersion effect of broadband laser-ultrasonic signal,we proposed time-domain filtering in multi-band method based on wavelet analysis to decompose the broadband signal into multiple narrowband ones and separate the scattering signals effectively without reference signal.On this basis,the total focusing method(TFM)was used for damage imaging.However,when the traditional TFM was applied to image based on ultrasonic Lamb wave,the inherent dispersion characteristic of ultrasonic Lamb wave could lead to the miscalculation of time delay,thus reducing the imaging precision.Therefore,the frequency-domain TFM was developed by applying phase delay in the frequency domain.The logical AND was introduced to synthesize the damage imaging results of multiple narrowband signals to obtain high-precision damage imaging.Our study has shown that the method of time-domain filtering in multi-band combining with frequency-domain TFM can realize non-contact and accurate damage detection in isotropic plate structures,and it is a potential effective method for application in engineering practice. | Fengzhong Li Ying Luo | 2021 | Acta Mechanica Solida Sinica2021，34，3： | 2 |
| 10 | Preface显示文摘 | fengzhong ke | 2005 | 北京林业大学学报2005，27，S2： | 1 |
| 11 | Equimolar mixture of c9,t11 and t9,t11 CLA inhibits the growth and induces apoptosis in Caco‐2 cells显示文摘 | Xian‐FengZhong TingLuo Gui‐DongHuang Ze‐YuanDeng LinLei | 2012 | Technol2012，，4： | 1 |
| 12 | Intelligent transportation space: vehicles, traffic, communications and beyond 显示文摘 | QU Fengzhong WANG Feiyue YANG Liuqing | 2010 | IEEE Communication Magazine2010，48，1： | 1 |
| 13 | Influence of the laser intensity in second-harmonic detection with TDLAS-Comparison of experiment and theory显示文摘 | Kan Ruifeng Dong Fengzhong Zhang Yujun | 2005 | Accepted by Chinese Physics in2005，，： | 1 |
| 14 | WATER HAMMER ANALYSIS OF WATER FEEDING SYSTEM IN COAL FIRED POWER STATION AND ITS INFLUENCE ON THE SAFETY OF OPERATION显示文摘In the coal fired power station, the regulation of the load or the sudden stop operation of the unit in accident may result in water hammer, which would have critical influence on the safe operation of the unit. In this paper, the analysis of the water dynamic characters and the calculation of the pressure increment are shown, when the water hammer is produced in the system . | Sun, Fengzhong Shan, Bo Li, Shuying Huang, Xinyuan | 1997 | Journal of Hydrodynamics1997，9，3： | 1 |
| 15 | Global stability and stabiliza- tion of more general stochastic nonlinear systems 显示文摘 | Li Fengzhong Liu Yungang | 2014 | Journal of Mathematical Analysis and Applications2014，413，2： | 1 |
| 16 | Experimental research of the guiding channels effect on the thermal performance of wet cooling towers subjected to crosswinds-Air guiding effect on cooling tower 显示文摘 | Wang Kai Sun Fengzhong Zhao Yuanbin | 2010 | Applied ThermalEngineering2010，，30： | 1 |
| 17 | Experimental research of the cross walls effect on the thermal performance of wet cooling tow- ers under erosswind conditions显示文摘 | CHEN Youliang SUN Fengzhong WANG Hong- guo | 2011 | Applied Thermal Engineering2011，31，1718： | 1 |
| 18 | Experimental research of the guiding channels effect on the thermal performance of wet cooling tow- ers subjected to crosswinds air guiding effect on cool- ing tower显示文摘 | WANG Kai SUN Fengzhong ZHAO Yuanbin | 2010 | Applied Thermal Engineering2010，30，5： | 1 |
| 19 | GC-MS Analysis on Form and Content of Phytosterol in the Beans from Different Producing Areas显示文摘This paper established the GC-MS method to analyze phytosterol in beans and study the content and distribution of phytosterol in green beans,red beans,black beans and soybeans in 5 main producing areas of China(Inner Mongolia,Heilongjiang,Jilin,Hebei,Shandong).This paper used GC-MS method to analyze the content and distribution of campesterol,stigmasterol,sitostanol,brassicasterol,ergosterol,cycloartanol,cycloartenol,2,4-methylenecycloartanol,spinasterol,cholesterol and cholestanol in the beans from different producing areas.Results showed that the content of sterol in green beans was higher than in three other kinds of beans,and the content of sterol in red beans was the lowest.Different producing areas had a significant impact on the content of sterol in beans,and the dominant producing areas included Inner Mongolia and Heilongjiang.The study provided a basis for quality assessment and nutritional evaluation of beans and provided a reference for traceability and variety distinction study of other edible beans. | Donghui WANG Yue ZHANG Bei FAN Lijing ZHANG Chao SHEN Fengzhong WANG | 2017 | Asian Agricultural Research2017，9，8： | 1 |
| 20 | A Change-Point Perspective on the Software Failure Process显示文摘 | Zou Fengzhong | 2003 | Software Testing Verification and Reliability2003，13，2： | 1 |
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