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您的检索式：作者名="Fernanda AM"
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| 1 | Active tuberculosis in inflammatory bowel disease patients under treatment from an endemic area in Latin America显示文摘BACKGROUND There has been an increase in cases of inflammatory bowel disease(IBD)in recent years.There is also greater access and availability of immunosuppressive and biological agents,which increase the risk of opportunistic infection despite improving the quality of life and promoting mucosal healing.Tuberculosis(TB)remains a public health problem,and it has a high incidence in several countries.Therefore,knowledge of the risk of developing TB in patients with IBD is important.AIM To evaluate the risk of active TB in patients with IBD under treatment from an endemic area in Latin America.METHODS A standard questionnaire included demographic variables,clinical aspects of IBD disease,history of active TB during treatment,active TB characteristics and evolution,initial screening and results and time from the start of anti-tumor necrosis factor alpha(TNFα)to TB development.RESULTS Azathioprine,anti-TNFα and the combination of these two drugs were associated with a higher risk of active TB incidence.The TNFα blockers increased the relative risk of developing active TB compared to other treatments.All four multivariable models showed that the use of TNFα blockers alone or in combination with azathioprine was an important risk factor for the incidence of active TB.After adjustment for sex,age,type of IBD and latent TB,anti-TNFα with azathioprine increased the relative risk to 17.8 times more than conventional treatment.Late TB,which was diagnosed 3 mo after the start of anti-TNFα,was the most frequent.CONCLUSION Treatment with anti-TNFα increased the risk of active TB in IBD patients from an endemic area in Latin America.This risk was increased when anti-TNFα was combined with azathioprine.The time from the beginning of the treatment to the active TB diagnosis suggests a new TB infection. | Flora Maria Lorenzo Fortes Ney Boa Sorte Victor D Mariano Laila D Andrade Fernanda A Oliveira Monique CA Santos Claudia Ivanilda N dos Santos Catharina A Passos Mila P Pacheco Valdiana C Surlo Neogelia P de Almeida Jaciane AM Fontes Andrea M Pimentel Raquel Rocha Genoile Oliveira Santana | 2020 | World Journal of Gastroenterology2020，26，44： | 1 |
| 2 | Correlation between chromosomal variants and male infertility in a population of Brazilian infertile men显示文摘 | Denise Mari C Fernanda AM Rubens PN | 2012 | Reproductive System&Sexual Disorders2012，1，1： | 1 |
| 3 | Pleistocene Birds of Gruta Nova da Columbeira(Bombarral-Portugal):A Paleontological and Paleoenvironmental Aproach显示文摘Discovered in 1962,the Columbeira cave has a Mousterian sequence dated between 101 and 35 Ka(U-series)and between 28,900 and 18,000 BP 14C.Excavations recovered abundant lithic implements and provided rich assemblage of vertebrates,including mammals,reptiles,birds and a remain of Homo neanderthalensis.In this work,authors present the taxonomy at the level of genus and species of the bird assemblage and its possible relationship with the paleoenvironments in which they lived.Thirteen species of birds have been identified out of 283 bones.Most of these bones are very fragmented and unsuitable for identification down to species or the genus level.Nevertheless,it is possible to say that the species vary through the sequence and that the assemblage is dominated by Pyrrhocorax,Corvus,Columba Turdus and Alectoris. | Silvério D. Figueiredo Fernanda Sousa Solange Silva Luís Raposo Telmo Pereira Américo Rosa | 2018 | Journal of Environmental Science and Engineering(A)2018，7，6： | 0 |
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