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| 1 | Endoscopic ultrasound-guided vs endoscopic retrograde cholangiopancreatography biliary drainage for obstructed distal malignant biliary strictures: A systematic review and meta-analysis显示文摘BACKGROUND For palliation of malignant biliary obstruction(MBO), the gold-standard method of biliary drainage is endoscopic retrograde cholangiopancreatography(ERCP)with the placement of metallic stents. Endoscopic ultrasound(EUS)-guided drainage is an alternative that is typically reserved for cases of ERCP failure.Recently, however, there have been robust randomized clinical trials(RCTs)comparing EUS-guided drainage and ERCP as primary approaches to MBO.AIM To compare EUS guidance and ERCP in terms of their effectiveness and safety in palliative biliary drainage for MBO.METHODS This was a systematic review and meta-analysis, in which we searched the MEDLINE, Excerpta Medica, and Cochrane Central Register of Controlled Trials databases. Only RCTs comparing EUS and ERCP for primary drainage of MBO were eligible. All of the studies selected provided data regarding the rates of technical and clinical success, as well as the duration of the procedure, adverse events, and stent patency. We assessed the risk of biases using the Jadad score and the quality of evidence using the Grading of Recommendations Assessment,Development and Evaluation criteria.RESULTS The database searches yielded 5920 records, from which we selected 3 RCTs involving a total of 222 patients(112 submitted to EUS and 110 submitted to ERCP). In the EUS and ERCP groups, the rate of technical success was 91.96%n and 91.81%, respectively, with a risk difference(RD) of 0.00%(95%CI:-0.07, 0.07;P = 0.97; I^2 = 0%). The clinical success was 84.81% and 85.53% in the EUS and ERCP groups, respectively, with an RD of-0.01%(95%CI:-0.12, 0.10; P = 0.90; I^2 =0%). The mean difference(MD) for the duration of the procedure was-0.12%(95%CI:-8.20, 7.97; P = 0.98; I^2 = 84%). In the EUS and ERCP groups, there were14 and 25 adverse events, respectively, with an RD of-0.06%(95%CI:-0.23, 0.12; P= 0.54; I^2 = 77%). The MD for stent patency was 9.32%(95%CI:-4.53, 23.18; P =0.19; I^2 = 44%). The stent dysfunction rate was significantly lower in the EUS t group(MD =-0.22%; 95 CI:-0.35,-0.08; P = 0.001; I^2 = 0%).CONCLUSION EUS represents an interesting alternative to ERCP for MBO drainage,demonstrating lower stent dysfunction rates compared with ERCP. Technical and clinical success, duration, adverse events and patency rates were similar. | Fernanda P Logiudice Wanderlei M Bernardo Facundo Galetti Vitor M Sagae Carolina O Matsubayashi Antonio C Madruga Neto Vitor O Brunaldi Diogo T H de Moura Tomazo Franzini Spencer Cheng Sergio E Matuguma Eduardo G H de Moura | 2019 | World Journal of Gastrointestinal Endoscopy2019，11，4： | 6 |
| 2 | Magnetic resonance imaging of the cirrhotic liver: An update显示文摘Noninvasive imaging has become the standard for hepatocellular carcinoma(HCC) diagnosis in cirrhotic livers. In this review paper, we go over the basics of MR imaging in cirrhotic livers and describe the imaging appearance of a spectrum of hepatic nodules marking the progression from regenerative nodules to low- and high-grade dysplastic nodules, and ultimately to HCCs. We detail and illustrate the typical imaging appearancesof different types of HCC including focal, multifocal, massive, diffuse/infiltrative, and intra-hepatic metastases; with emphasis on the diagnostic value of MR in imaging these lesions. We also shed some light on liver imaging reporting and data system, and the role of different magnetic resonance imaging(MRI) contrast agents and future MRI techniques including the use of advanced MR pulse sequences and utilization of hepatocyte-specific MRI contrast agents, and how they might contribute to improving the diagnostic performance of MRI in early stage HCC diagnosis. | Agnes Watanabe Miguel Ramalho Mamdoh Al Obaidy Hye Jin Kim Fernanda G Velloni Richard C Semelka | 2015 | World Journal of Hepatology2015，7，3： | 5 |
| 3 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 4 | Serum Thyrotropin Levels Following Levothyroxine Administration at Breakfast显示文摘 | Camila LSP Fernanda SA Hans G | 2013 | Thyroid2013，23，7： | 1 |
| 5 | Wine and grape polyphenols-a chemical perspective 显示文摘 | JORGE G FERNANDA B | 2011 | Food Research International2011，44，10： | 1 |
| 6 | Additional 3- nitropropanoyl esters of glucose from lndigoferasuffruticosa (Leguminosae) 显示文摘 | Wahnir S G Fernanda R Barison A | 2003 | Biochem Syst Ecol2003，31，2： | 1 |
| 7 | A framework for measuring logistics performance in the wine industry 显示文摘 | FERNANDA A GARCIA MARTIN G MARCHETTA MAURICIO CAMARGO | 2012 | International Journal of Production Eco- nomics2012，，135： | 1 |
| 8 | Synthesis and Biological Evaluation of Some 6-Substi?tuted Purines显示文摘 | FERNANDA G B ELAINE S C MAGNUM 0 M | 2007 | EurJ of Med Chern2007，42，： | 1 |
| 9 | Method of quantifying the loss of acidification activity of lactic acid starters during freezing and frozen storage 显示文摘 | FERNANDA F BEAL C CORRIEU G | 2000 | Dairy Research2000，67，： | 1 |
| 10 | Molecular model of cyclin-dependent kinase S complexed with roscovitine显示文摘 | Walter F A Renato T G Fernanda C | 2002 | Biochem Biophys Res Commun2002，297，5： | 1 |
| 11 | Methods and parameters of melting curve analysis for identification of Leishmania species:A scoping review显示文摘Leishmaniasis is a set of diseases with a worldwide distribution that affects mainly economically underprivileged populations in developing countries. It has a major impact on public health, with a global cost of billions of dollars per year. The treatment and control of leishmaniasis vary according to the Leishmania species involved, which require reliable methods for species identification. Since most of the currently used methods have limitations, there is a need for assays that allow rapid, precise identification of the offending species. Real-time polymerase chain reactions in conjunction with dissociation curve analysis have been used to detect differences in the DNA composition of selected genes of Leishmania spp. Kinetoplast DNA is the main molecular target used because of its high copy number per parasite, but other targets have also been studied. As part of an effort to establish melting temperature standards for each target gene, we have reviewed the pertinent literature available in public databases, including Pub Med, Web of Science, Sci ELO and LILACS, using the keywords 'Leishmania', 'leishmaniasis', 'realtime PCR', 'melting temperature', and 'melting curve', alone or in combination. After applying eligibility criteria, 27 articles were selected for analysis. A considerable variation in the methodologies analyzed was found regarding molecular targets, standardization of the methods, reproducibility and specificity. Because of this, statistical analysis was not performed. In most cases, the methods were able to differentiate the parasite at the subgenus level or few species regardless of the target chosen. | Juliana J G Ferreira Fernanda S Nascimento Glaucia E B Marcon Eros A de Almeida Sandra C B Costa | 2021 | Asian Pacific Journal of Tropical Medicine2021，14，12： | 1 |
| 12 | Grain and floret number in response to photoperiod during stem elongation in fully and slightly vernalized wheats显示文摘 | Fernanda G Gonzalez Gustavo A | 2003 | Field Crops Research2003，81，： | 1 |
| 13 | 显示文摘 | Lueiana cla C Fernanda M B C Viviane G T | 2008 | Polymer Bul- letin2008，61，3： | 1 |
| 14 | Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma显示文摘 | Staquicini Fernanda I Ozawa Michael G Moya Catherine A Driessen Wouter H P Barbu E Magda Nishimori Hiroyuki Soghomonyan Suren Flores Leo G Liang Xiaowen Paolillo Vincenzo Alauddin Mian M Basilion James P Furnari Frank B Bogler Oliver Lang F | 2011 | Journal of Clinical Investigation2011，，1： | 1 |
| 15 | Antimicrobial and antioxidant properties of chitosan enzymatically functionalized with flavonoids显示文摘 | Fernanda S Georg M G Vanja K | 2009 | Process Biochemistry2009，44，7： | 1 |
| 16 | Use of UHPFRC overlay to reduce stresses in orthotropic steel decks 显示文摘 | Lamine D Pierre M Fernanda G | 2013 | Journal of Constructional Steel Research2013，89，5： | 1 |
| 17 | Revealing climatic variability of the last three millennia in northwestern Iberia using pollen influx data 显示文摘 | Desprat S María Fernanda S G Loutre M F | 2003 | Earth and Planetary Science Letters2003，213，12： | 1 |
| 18 | The role of cerium in the oxidation of ethanol over SnO2 - supported molybdenum oxides 显示文摘 | Fernanda M G Paulo R S Medeiros Lucia G Appel | 2001 | Appl Catal A : General2001，208，： | 1 |
| 19 | Synthesis,characterization and evaluation of sulfonic resins as catalysts显示文摘 | Fernanda M B C Rosane R S Ailton S G | 2004 | European Polymer Journal2004，40，7： | 1 |
| 20 | Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats显示文摘瞄准:在一个动物模型在不含酒精的脂肝疾病(NAFLD ) 的预防每氧化和口头的 SNAC 管理的效果在类脂化合物的抑制评估 S-nitroso-N-acetylcysteine (SNAC ) 的潜力。方法:NAFLD 被胆碱缺乏的饮食为 4 wk 在 Wistar 雄的老鼠导致。对待 SNAC 的动物(n=6 )(1.4 mg/kg 每 SNAC 的天,口头上地) 与 2 个控制组相比:(n=6 ) 收到了 PBS 答案,其它(n=6 ) 收到了 NAC 答案(7 mg/kg 每天) 。组织学的变量半关于宏和 microvacuolar 脂肪被测定变化,它的带的分发,坏死的 foci,门和 perivenular 纤维变性,并且煽动性与带的分发渗入。从肝 homogenates 的样品的 LOOH 被 HPLC 确定。在门静脉的血浆的硝酸盐层次被化合光估计。水的低密度的脂蛋白(LDL ) 暂停(200 microg protein/mL ) 在 37 度摄氏为 15 h 在 SNAC (300 micromol/L ) 的缺席和存在与 CuCl (2 )(300 micromol/L ) 被孵化。LDL 氧化的程度被 fluorimetry 估计。亚油酸(LA )(18.8 micromol/L ) 氧化被大豆 lipoxygenase (SLO )(0.056 micromol/L ) 当面在 37 度摄氏导致并且 N-acetylcysteine (NAC ) 和 SNAC (56 和 560 micromol/L ) 的缺席并且在 234 点监视了 nm。结果:在控制组的动物在仙子门区域开发了中等的宏和微小囊的丰满的变化。对待 SNAC 的动物与丰满的变化的缺席显示了仅仅分离的组织学的改变并且没得肝脂肪变性。在对待 SNAC 的组的 NAFLD 的缺席断然在肝匀浆在 LOOH 的集中与减少被相关,与控制组相比(0.7+/-0.2 nmol/mg 对 3.2+/-0.4 nmol/mg 蛋白质,分别地 P<0.05 ) ,当 aminotransferases 的浆液层次是未改变的时。在每氧化阻止类脂化合物的 SNAC 的能力作为模型底层用 LA 和 LDL 在在试管内实验被证实。结论:SNAC 的口服在用胆碱缺乏的饮食喂的 Wistar 老鼠阻止 NAFLD 的发作。这效果与 SNAC 的能力被相关每氧化在试管内和在试管内堵住类脂化合物的繁殖。 | Claudia PMS de Oliveira Fernanda I Simplicio Vicencia MR de Lima Katia Yuahasi Fabio P Lopasso Venancio AF Alves Dulcinéia SP Abdalla Flair J Carrilho Francisco RM Laurindo Marcelo G de Oliveira | 2006 | World Journal of Gastroenterology2006，12，12： | 1 |
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