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| 1 | Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy:A case report and review of literature显示文摘BACKGROUND Primary extra-gastrointestinal stromal tumors(E-GIST)of the liver are rare.The clinical presentation may range from asymptomatic to bleeding or manifestations of mass effect.Oncologic surgery followed by adjuvant therapy with imatinib is the standard of care.However,under specific circumstances,a cytoreductive approach may represent a therapeutic option.We describe herein the case of an 84-year-old woman who presented with a tender,protruding epigastric mass.Abdominal computed tomography scan revealed a large,heterogeneous mass located across segments III,IV,V,and VIII of the liver.The initial approach was transarterial embolization of the tumor,which elicited no appreciable response.Considering the large size and central location of the tumor and the advanced age of the patient,non-anatomic complete resection was indicated.Due to substantial intraoperative bleeding and hemodynamic instability,only a near-complete resection could be achieved.Histopathology and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the liver.Considering the risk/benefit ratio for therapeutic options,debulking surgery may represent a strategy to control pain and prolong survival.CASE SUMMARY Here,we present a case report of a patient diagnosed with E-GIST primary of the liver,which was indicated a cytoreductive surgery and adjuvant therapy with imatinib.CONCLUSION E-GIST primary of the liver is a rare conditional,the treatment is with systemic therapy and total resection surgery.However,a cytoreductive surgery will be necessary when a complete resection is no possible. | Michel Ribeiro Fernandes Caroline Lorenzoni Almeida Ghezzi Tomaz J M Grezzana-Filho Flávia Heinz Feier Ian Leipnitz Aljamir Duarte Chedid Carlos Thadeu Schmidt Cerski Marcio Fernandes Chedid Cléber RositoPinto Kruel | 2021 | World Journal of Gastrointestinal Surgery2021，13，3： | 3 |
| 2 | Detection of contaminants in cell cultures, sera and trypsin显示文摘 | Tatiana Flávia Pinheiro de Oliveira Ant?nio Augusto Fonseca Marcelo Fernandes Camargos Anapolino Macedo de Oliveira Ana Cláudia Pinto Cottorello Antonizete dos Reis Souza Iassudara Garcia de Almeida Marcos Bryan Heinemann | 2013 | Biologicals2013，，6： | 2 |
| 3 | Diabetic Nephropathy Amelioration by a Low-Dose Sitagliptin in an Animal Model of Type 2 Diabetes (Zucker Diabetic Fatty Rat)显示文摘 | Cristina Mega Edite Teixeira de Lemos Helena Vala Rosa Fernandes Jorge Oliveira Filipa Mascarenhas-Melo Frederico Teixeira Flávio Reis Yoshio Shimizu | 2011 | Experimental Diabetes Research2011，，： | 1 |
| 4 | Influence of Total Intravenous Anesthesia, Entropy and Laparoscopy on Oxidative Stress显示文摘 | Rogean Rodrigues Nunes Fernando Squeff Nora Danielle Maia Holanda Dumaresq Rute Maria Araújo Cavalcante Amanda Antunes Costa Lara Moreira Mendes Carneiro Julio Cesar Garcia de Alencar Flávia Pereira Fernandes Cardoso | 2012 | Brazilian Journal of Anesthesiology2012，，4： | 1 |
| 5 | Correlation between shaking behaviors and seizure severity in five animal models of convulsive seizures显示文摘 | Rodrigues MC Rossetti F Foresti ML Arisi GM Furtado MA Dal-Có1 ML Bertti P Fernandes A Santos FL Del Vecchio F Garcia-Cairasco N | | 0，，03： | 1 |
| 6 | Xylo-oligosaccharides from lignocellulosic materials: Chemical structure, health benefits and production by chemical and enzymatic hydrolysis显示文摘 | Ana Flávia Azevedo Carvalho Pedro de Oliva Neto Douglas Fernandes da Silva Gláucia Maria Pastore | 2013 | Food Research International2013，，1： | 1 |
| 7 | Bacterial adhesion on the titanium and zirconia abutment surfaces显示文摘 | Cássio do Nascimento Murillo Sucena Pita Flávio Henrique Nogueira Carri?o Fernandes Vinícius Pedrazzi Rubens Ferreira de Albuquerque Junior Ricardo Faria Ribeiro | 2014 | Clin Oral Impl Res2014，，3： | 1 |
| 8 | Brain-derived neurotrophic factor and neuron-specific enolase, but not S100 β , levels are associated to the occurrence of delirium in intensive care unit patients显示文摘 | Carmen Grandi Cristiane Damiani Tomasi Keiti Fernandes Laura Stertz Flávio Kapczinski Jo?o Quevedo Felipe Dal-Pizzol Cristiane Ritter | 2011 | Journal of Critical Care2011，，2： | 1 |
| 9 | Hi Focus Helix electrode insertion:surgical approach显示文摘 | Castilho AM Pauna HF Fernandes FL | 2015 | BMC research notes2015，8，1： | 1 |
| 10 | First-Line Paclitaxel and Carboplatin in Persistent/Recurrent or Advanced Cervical Cancer: A Retrospective Analysis of Patients Treated at Brazilian National Cancer Institute显示文摘 | álvaro Henrique Ingles Garces Paulo Alexandre Ribeiro Mora Flávia Vieira Guerra Alves Claudio Calazan do Carmo Rachele Grazziotin Anna Cristina Ferr?o Mangia Fernandes Angélica Nogueira-Rodrigues Andréia Cristina de Melo | 2013 | International Journal of Gynecological Cancer2013，，4： | 1 |
| 11 | Effects of Sitagliptin Treatment on Dysmetabolism, Inflammation, and Oxidative Stress in an Animal Model of Type 2 Diabetes (ZDF Rat)显示文摘 | Liliana Ferreira Edite Teixeira-de-Lemos Filipa Pinto Belmiro Parada Cristina Mega Helena Vala Rui Pinto Patrícia Garrido José Sereno Rosa Fernandes Paulo Santos Isabel Velada Andreia Melo Sara Nunes Frederico Teixeira Flávio Reis Gema Frühbeck | 2010 | Mediators of Inflammation2010，，： | 1 |
| 12 | Mechanical, physical, and chemical characterization of Ti–35Nb–5Zr and Ti–35Nb–10Zr casting alloys显示文摘 | Ana Lúcia Roselino Ribeiro Rubens Caram Junior Flávia Farias Cardoso Romeu Belon Fernandes Filho Luís Geraldo Vaz | 2009 | Journal of Materials Science: Materials in Medicine2009，，8： | 1 |
| 13 | β1 Adrenergic receptor is key to cold- and diet-induced thermogenesis in mice显示文摘 | Cintia B Ueta Gustavo W Fernandes Luciane P Capelo Tatiane L Fonseca Flávia D’Angelo Maculan Cecilia H A Gouveia Patrícia C Brum Marcelo A Christoffolete Marcelo S Aoki Carmen L Lancellotti Brian Kim Antonio C Bianco Miriam O Ribeiro | 2012 | Journal of Endocrinology2012，，3： | 1 |
| 14 | Larynx cancer: quality of life and voice after treatment显示文摘 | Rossi VC Fernandes FL Ferreira MA | 2014 | Braz J Otorhinolaryngol2014，80，5： | 1 |
| 15 | Can gadoxetic acid–enhanced magnetic resonance imaging be used to avoid liver biopsy in patients with nonalcoholic fatty liver disease?显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major cause of liver disease worldwide.The diagnosis of nonalcoholic steatohepatitis(NASH),the most severe form of NAFLD,is crucial and has prognostic and therapeutic implications.However,currently this diagnosis is based on liver biopsy and has several limitations.AIM To evaluate the performance of gadoxetic acid–enhanced magnetic resonance imaging(GA-MRI)in differentiating isolated steatosis from NASH in patients with NAFLD.METHODS In this prospective study,56 patients with NAFLD(18 with isolated steatosis and 38 with NASH)underwent GA-MRI.The contrast enhancement index(CEI)was calculated as the rate of increase of the liver-to-muscle signal intensity ratio from before and 20 min after intravenous GA administration.Between-group differences in mean CEI were examined using Student's t test.The area under the receiver operator characteristic curve and the diagnostic performance of gadoxetic acid–enhanced magnetic resonance imaging were evaluated.RESULTS The mean CEI for all subjects was 1.82±0.19.The mean CEI was significantly lower in patients with NASH than in those with isolated steatosis(P=0.008).Two CEI cut-off points were used:<1.66(94%specificity)to characterize NASH and>2.00(89%sensitivity)to characterize isolated steatosis.CEI values between 1.66 and 2.00 indicated liver biopsy,and the procedure could be avoided in 40%of patients with NAFLD.CONCLUSION GA-MRI is an effective noninvasive method that may be useful for the differentiation of NASH from isolated steatosis,and could help to avoid liver biopsy in patients with NAFLD. | Viviane Brandão Amorim Daniella Braz Parente Fernando Fernandes Paiva Jaime Araújo Oliveira Neto Amanda Almeida Miranda Cláudia Cravo Moreira Flávia Ferreira Fernandes Carlos Frederico FerreiraCampos Nathalie Carvalho Leite Renata de Mello Perez Rosana Souza Rodrigues | 2020 | World Journal of Hepatology2020，12，9： | 0 |
| 16 | In vitro induced pluripotency from urine-derived cells in porcine显示文摘BACKGROUND The generation of induced pluripotent stem cells(iPSC)has been a game-changer in translational and regenerative medicine;however,their large-scale applicability is still hampered by the scarcity of accessible,safe,and reproducible protocols.The porcine model is a large biomedical model that enables translational applications,including gene editing,long term in vivo and offspring analysis;therefore,suitable for both medicine and animal production.AIM To reprogramme in vitro into pluripotency,and herein urine-derived cells(UDCs)were isolated from porcine urine.METHODS The UDCs were reprogrammed in vitro using human or murine octamer-binding transcription factor 4(OCT4),SRY-box2(SOX2),Kruppel-like factor 4(KLF4),and C-MYC,and cultured with basic fibroblast growth factor(bFGF)supplementation.To characterize the putative porcine iPSCs three clonal lineages were submitted to immunocytochemistry for alkaline phosphatase(AP),OCT4,SOX2,NANOG,TRA181 and SSEA 1 detection.Endogenous transcripts related to the pluripotency(OCT4,SOX2 and NANOG)were analyzed via reverse transcription quantitative realtime polymerase chain reaction in different time points during the culture,and all three lineages formed embryoid bodies(EBs)when cultured in suspension without bFGF supplementation.RESULTS The UDCs were isolated from swine urine samples and when at passage 2 submitted to in vitro reprogramming.Colonies of putative iPSCs were obtained only from UDCs transduced with the murine factors(mOSKM),but not from human factors(hOSKM).Three clonal lineages were isolated and further cultured for at least 28 passages,all the lineages were positive for AP detection,the OCT4,SOX2,NANOG markers,albeit the immunocytochemical analysis also revealed heterogeneous phenotypic profiles among lineages and passages for NANOG and SSEA1,similar results were observed in the abundance of the endogenous transcripts related to pluripotent state.All the clonal lineages when cultured in suspension without bFGF were able to form EBs expressing ectoderm and mesoderm layers transcripts.CONCLUSION For the first time UDCs were isolated in the swine model and reprogrammed into a pluripotentlike state,enabling new numerous applications in both human or veterinary regenerative medicine. | Kaiana Recchia Lucas Simões Machado Ramon Cesar Botigelli Naira Caroline Godoy Pieri Gabriela Barbosa Raquel Vasconcelos Guimarães de Castro Mariana Groke Marques Laís Vicari de Figueiredo Pessôa Paulo Fantinato Neto Flávio Vieira Meirelles Aline Fernanda de Souza Simone Maria Massami Kitamura Martins Fabiana Fernandes Bressan | 2022 | World Journal of Stem Cells2022，14，3： | 0 |
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