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| 1 | 未处理或上游法处理后精子的DNA碎片能否预测使用赠卵ICSI后的妊娠?显示文摘本研究比较了未处理的精子和上游法处理后精子中的DNA碎片值(SDF)预测使用赠卵ICSI后妊娠的可能性。总共81例不孕女性接受通过夫精和赠卵ICSI后的胚胎移植。这种方式排除了目前公认的影响精子DNA修复的女方因素。在ICSI受精时,同时使用DNA碎片率检测试剂盒(Halosperm)进行盲法检测未处理的和上游法处理后精液中的精子DNA碎片。经上游法处理后的精液样本中SDF值呈显著下降。有趣的是,未处理的或上游法处理后精液样本中的SDF值均能预测妊娠。通过ROC曲线和其衍生的约登指数计算得出未处理前和上游法处理后精子sDF的临界值分别是24.8%和17.5%。未处理精子SDF预测妊娠的敏感性和特异性分别为75%和69%,而上游法处理后的精子SDF预测妊娠的敏感性和特异性分别是78%和73%。虽然SDF值增高与生育呈负相关,但我们发现在精子筛选降低sDF值后再与赠卵进行ICSI并不能保证获得妊娠。这表明目前的技术手段对于一些DNA损伤仍无法探及,从而相对影响辅助生殖成功的机率。因此,我们认为对目前的“冰山模式”作一些修饰后可以用来解释SDF在生育中的作用。 | Jaime Gosálvez Pedro Caballero Carmen López-Fernández Leonor Ortega José Andrés Guijarro José Luís FernAndez Stephen D Johnston Rocio Nufiez-Calonge | 2013 | Asian Journal of Andrology2013，15，6： | 3 |
| 2 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 3 | Cadmium inhibition of a structural wheat peroxidase显示文摘 | Converso D A Fernandez M E Tomaro M L | 2000 | J Enzy Inhib2000，15，： | 2 |
| 4 | Study of gastrointestinal transit times with capsule endoscopy 显示文摘 | Velayos Jimenez B Fernandez Salazar L Aller de la Fuente R | 2005 | Gastroenterol Hepatol2005，28，6： | 1 |
| 5 | Postpartum hemolytic uremic syndrome:a rare entity and a treatment challenge 显示文摘 | Alsina Segui E Martin Conde M Craver Hospital L Fernandez Oiraldez E | 2008 | Nefrologia2008，28，： | 1 |
| 6 | Role of ischemic preconditioning and the portosystemic shunt in the prevention of liver and lung damage after rat liver transplantation显示文摘 | Fernandez L Heredia N Peralta C | 2003 | Transplantation2003，76，2： | 1 |
| 7 | Incidence on power system dynamics of high penetration of fixed speed and doubly fed wind energy systems-study of the spanish case显示文摘 | Fernandez J L Beato D | 2002 | IEEE Transactions on Power Systems2002，17，4： | 1 |
| 8 | Determinants of innovation through a knowledge -based theory lens显示文摘 | Aranda D A Molina- Fernandez L M | 2002 | Industrial Management Data Systems2002，102，56： | 1 |
| 9 | Effect of chromium tripicolinate on growth, glucose tolerance, insulin sensitivity, plasma metabolites, and growth hormone in pigs 显示文摘 | AMOIKON E K FERNANDEZ J M SOUTHERN L L | 1995 | Journal of Animal Science1995，73，： | 1 |
| 10 | The matrix metalloproteinase-9/neutrophil gelatinase-associated lipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients显示文摘 | Fernandez CA Yan L Louis G | 2005 | Clin Cancer Res2005，11，： | 1 |
| 11 | Transition to androgen-independence in prostate cancer 显示文摘 | Navarro D Luzardo OP Fernandez L | 2002 | J Steroid Biochem Mol Biol2002，81，3： | 1 |
| 12 | Learning in large cooperative multi-robot domains显示文摘 | FERNANDEZ F PARLER L E | 2001 | International Journal of Robotics and Automation2001，16，4： | 1 |
| 13 | Interleukin-1 increases fibronectin production by cultured rat cardiac fibroblasts显示文摘 | Fernandez L Mosqucra JA | 2002 | Pathobiology2002，70，4： | 1 |
| 14 | The effect of music amplitude on the reaction to unexpected visual events显示文摘 | Turner M L Fernandez J E Nelson K | 1996 | The Journal of General Psychol ogy1996，123，1： | 1 |
| 15 | Mannose-binding lectin gene polymorphisms are associated with gestational diabetes mellitus显示文摘 | Megia A Gallart L Fernandez RJM | | 0，，10： | 1 |
| 16 | Conventional and microwave induced pyrolysis of coffee hulls for the production of hydrogen rich fuel gas显示文摘 | DOMINGUEZ A MENENDEZ J A FERNANDEZ Y PIS J J VALENTE NABAIS JM CARROTT J M RIBEIRO CARROTT M M L | | 0，，1： | 1 |
| 17 | Biotic and abiotic causes of yield failure in tropical aerobic rice显示文摘 | Kreye C Bouman B A M Reversat G Fernandez L Faronilo J E Llorca L | | 0，，： | 1 |
| 18 | Design and Implementation of a Soil Geographic Data base for Rural Planning and Management 显示文摘 | FERNANDEZ R N RUSINKIEWICZ M DASILVA L M | 1993 | Journal of Soil and Water Conservation1993，48，2： | 1 |
| 19 | AVATAR: an improved solution for personalized TV based on semantic inference 显示文摘 | Fernandez Y B Pazos Arias J J Nores M L | 2006 | Consumer Electronics IEEE Transactions on2006，52，1： | 1 |
| 20 | Struc-ture-properties relationship for resols with different formalde-hyde/phenol molar ratio显示文摘 | Manfredi L B de la Osa O Galego Fernandez N | 1999 | Ploymer1999，40，13： | 1 |
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