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| 1 | Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori显示文摘AIM: To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H pylori).METHODS: Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H pylori to stomach sections. RESULTS: Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric; borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections.CONCLUSION: Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment. | Rachel O'Mahony Huda Al-Khtheeri Deepaka Weerasekera Neluka Fernando Dino Vaira John Holton Christelle Basset | 2005 | World Journal of Gastroenterology2005，11，47： | 29 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial显示文摘 | John Primrose Stephen Falk Meg Finch-Jones Juan Valle Derek O’Reilly Ajith Siriwardena Joanne Hornbuckle Mark Peterson Myrddin Rees Tim Iveson Tamas Hickish Rachel Butler Louise Stanton Elizabeth Dixon Louisa Little Megan Bowers Sian Pugh O James Garden D | 2014 | Lancet Oncology2014，，6： | 2 |
| 4 | Association of cardiovascular system medications with cognitive function and dementia in older adults living in nursing homes in Australia显示文摘ObjectiveTo 在在检验生活和资源使用的质量的 17 所澳大利亚的疗养院的代表性的研究的 Australia.MethodsAs 部分住在疗养院的更老的成年人与认知功能和痴呆的诊断检验在心血管的系统药使用之间的协会,我们检验了在认知缺陷和心血管的药使用之间的协会(使用解剖治疗学的分类系统识别)用一般线性回归和逻辑 regressio 正在收到生活照顾的结束的人是包括的 excluded.ResultsParticipants 有一个平均数的 541 个居民 85.5 | Enwu Liu Suzanne M Dyer Lisa Kouladjian O'Donnell Rachel Milte Clare Bradley Stephanie L Harrison Emmanuel Gnanamanickam Craig Whitehead Maria Crotty | 2017 | Journal of Geriatric Cardiology2017，14，6： | 2 |
| 5 | Resistance to Chloride Intrusion of Concrete Cured at Different Temperatures显示文摘 | Detwiler Rachel J Kjellsen Knut O Gjorv Odde | 1991 | ACI Materials Journal1991，88，1： | 1 |
| 6 | Matrix-assisted laser desorption/ionization-mass spec- trometry of hydrophobic proteins in mixtures显示文摘 | RACHEL R O | 2011 | Sample Preparation in Biological Mass Spectrometry2011，10，3： | 1 |
| 7 | Transmembrane semaphorin5B is proteolytically processed into a repulsive neural guidance cue显示文摘 | Kristen Browne Wenyan Wang Rachel Q. Liu Matthew Piva Timothy P. O’Connor | 2012 | Journal of Neurochemistry2012，，： | 1 |
| 8 | The effect of oxygen on the sporulation and toxicity of Bacillus sphericus 2362 显示文摘 | Mohamed I A K Rachel J L Keith J O | 1993 | Biotechnology letters1993，15，1： | 1 |
| 9 | CMOS-based phase fluorometric oxygen sensor system显示文摘 | Vamsy P C Daniil O S Rachel M B | 2007 | IEEE Trans-actions on Circuts and System-I : Regular Papers2007，54，1： | 1 |
| 10 | Postpartum Hemorrhage显示文摘 | Rachel P Iris O Gershon H | 2011 | Bleeding During Pregnancy2011，4，2： | 1 |
| 11 | Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists显示文摘 | Wei Wang Pratik Devasthale Dennis Farrelly Liqun Gu Thomas Harrity Michael Cap Cuixia Chu Lori Kunselman Nathan Morgan Randy Ponticiello Rachel Zebo Litao Zhang Kenneth Locke Jonathan Lippy Kevin O’Malley Vinayak Hosagrahara Lisa Zhang Pathanjali Kadiyala | 2008 | Bioorganic & Medicinal Chemistry Letters2008，，6： | 1 |
| 12 | Neurocognitive performance and functional disability in the psychosis prodrome显示文摘 | Tara A. Niendam Carrie E. Bearden Jennifer K. Johnson Malin McKinley Rachel Loewy Mary O’Brien Keith H. Nuechterlein Michael F. Green Tyrone D. Cannon | 2006 | Schizophrenia Research2006，，1： | 1 |
| 13 | Respiratory activity in the marine cyanobacterium Spirulina subsalsa and its role in salt tolerance显示文摘 | Rachel G A Mordechay S Khoshana T O Rachel M Elisha T O | 1992 | Arch Micobiol1992，157，2： | 1 |
| 14 | Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer’s disease显示文摘 | Victor Villemagne Rachel Mulligan Svetlana Pejoska Kevin Ong Gareth Jones Graeme O’Keefe J. Chan Kenneth Young Henri Tochon-Danguy Colin Masters Christopher Rowe | 2012 | European Journal of Nuclear Medicine and Molecular Imaging2012，，： | 1 |
| 15 | Prognosis of acute severe autoimmune hepatitis (AS-AIH): The role of corticosteroids in modifying outcome显示文摘 | Andrew D. Yeoman Rachel H. Westbrook Yoh Zen William Bernal Thawab Al-Chalabi Julia A. Wendon John G. O’Grady Michael A. Heneghan | 2014 | Journal of Hepatology2014，，： | 1 |
| 16 | Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats 显示文摘 | Hande G Hilal O Rachel N | 1998 | Toxicology1998，128，3： | 1 |
| 17 | Effect of eradication ofHelicobacter pylori infection on gastric epithelial cell proliferation显示文摘 | Rachel J. Cahill MD H Xia MD PhD Clive Kilgallen MB Shona Beattie SRN Hilary Hamilton SRN Prof. Colm O’morain MD MSc FRCP | 1995 | Digestive Diseases and Sciences1995，，8： | 1 |
| 18 | A novel serum microRNA panel to discriminate benign from malignant ovarian disease显示文摘 | Ream Langhe Lucy Norris Feras Abu Saadeh Gordon Blackshields Rachel Varley Ashling Harrison Noreen Gleeson Cathy Spillane Cara Martin Dearbhaile M. O’Donnell Tom D’Arcy John O’Leary Sharon O’Toole | 2014 | Cancer Letters2014，，： | 1 |
| 19 | and Gjorv Odde, resistance to chloride intrusion of concrete cured at different temperatures 显示文摘 | Detwiler Rachel J Kjellsen Knut O | 1991 | ACI Materials Journal1991，88，1： | 1 |
| 20 | Bank branch closures in New Zealand: the application of a spatial interaction model显示文摘 | Philip S Morrison Rachel O’Brien | 2001 | Applied Geography2001，，4： | 1 |
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