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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Bladder exstrophy and phenotypic gender determination on fetal magnetic resonance imaging 显示文摘 | Hsieh K O'Loughlin MT Ferrer FA | 2005 | Urology2005，65，5： | 1 |
| 3 | Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development显示文摘 | Rodríguez-Concepción M Forés O Martínez-García J.F González V Phillips M.A Ferrer A and Boronat A | | 0，，： | 1 |
| 4 | Radiant flash pyrolysis of cellulose-evidence for the formation of short life time intermediate liquid species显示文摘 | FERRER M LEDE J | 1998 | Journal of Analytical and Applied Pyrolysis1998，47，1： | 1 |
| 5 | Biochemical structure features of a novel cyclodextrinase from cow rumen metagenome显示文摘 | Ferrer M Beloqui A Golyshina O V | 2007 | Biotechnology Journal2007，2，： | 1 |
| 6 | Determination af O3 and CO2 Transmission Rates through Microperforated Films for Modified Atmosphere Packaging of Fresh Fruits and Vegetables显示文摘 | JAIME G FERRER A SALVADOR O R | 2008 | Journal of Food Engineering2008，86，： | 1 |
| 7 | Ground resistance of concrete foundation in substation yards显示文摘 | Thapar B Ferrer O Blank D A | 2000 | IEEE Tmns on Magnetics2000，36，6： | 1 |
| 8 | Effect of corticosteroids on treatment failure among hospitalized patients with severe community-acquired pneumonia and high inflammatory response:a randomized clinical trial显示文摘 | Torres A Sibila O Ferrer M | 2015 | JAMA2015，313，7： | 1 |
| 9 | Noninvasive yentilation after intubation and mechanical ventilation显示文摘 | FERRER M BERNADICH O NAvA S | 2002 | Eur Respir J2002，19，5： | 1 |
| 10 | Differential cellular distribution and dynamics of HSP70, cyclooxygenase-2, and c-Fos in the rat brain after transient focal ischemia or kainic acid 显示文摘 | Sanz O Estrada A Ferrer I | 1997 | Neuroscience1997，80，1： | 1 |
| 11 | Liquid chromatography-high-resolution mass spectrometry for pesticide residue analysis in fruit and vegetables:Screening and quantitative studies显示文摘 | GóMEZ-RAMOS M M FERRER C MALATO O | 2013 | Journal of Chromatography A2013，1287，： | 1 |
| 12 | Novel hydrolase diversity retrieved from a metagenome library of bovine rumen micro flora 显示文摘 | FERRER M GOLYSHINA O V CHERNIKOVA T N | 2005 | Environmental Microbiology2005，7，12： | 1 |
| 13 | Dynamic angiography in age related macular degeneration显示文摘 | Torron Fernandez-Blanco C Perez Olivan S Melcon Sanc-hez-Friera B Ferrer Novella E Ruiz-Moreno O Honrubia Lopez FM | 2002 | Arch Soc Esp Oftalmol2002，77，： | 1 |
| 14 | Radiant flash pyrolysis of cellulose-evidence for the formation of short life time intermediate liquid species 显示文摘 | BOUTIN O FERRER M LéDé J | 1998 | Journal of Analytical and Applied Pyrolysis1998，47，1： | 1 |
| 15 | Noninvasive ventilation after intubation and mechanical ventilation 显示文摘 | Ferrer M Bemadich O Nava S | 2002 | Eur Respir J2002，19，5： | 1 |
| 16 | Radiant Flash Pyrolysis of Cellulose--Evidence for the Formation of Short Life Time Intermediate Liquid Species 显示文摘 | Boutin O Ferrer M LIDI J | 1998 | Journal of Analytical and Applied Pyrolysis1998，47，1： | 1 |
| 17 | No- vel hydrolase diversity retrieved from a metagenome library of bovine rumen microflorar显示文摘 | Ferrer M Golyshina O V Chernikova T N | 2005 | Environmental Microbiology2005，7，12： | 1 |
| 18 | Noninvasive ventilation after intubation and mechanical ventilation显示文摘 | Bernadich O Nava S | 2002 | Eur Respir J2002，19，5： | 1 |
| 19 | Therapeutic drug monito- ring of lamotrigine 显示文摘 | Bentu Ferrer D Tribut O Verdier MC | 2010 | Th6rapie2010，65，： | 1 |
| 20 | Longterm comparisonofcornealaberrationchangesafterlaserinsitukeratomileusis:mechanicalmicrokeratomeversusfemtosecondlaserflapcreation显示文摘 | MuozG AlbarránDiegoC FerrerBlascoT GarcíaLázaroS CervioExpósitoA | 2010 | JCataractRefractSurg2010，36，11： | 1 |
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