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| 1 | Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations显示文摘 | Thompson MC Fuller C Hogg TL Dalton J Finkelstein D Lau CC Chintagumpala M Adesina A Ashley DM KeUie SJ Taylor MD Curran T Gajjar A Gilbertson RJ | 2006 | 中国神经肿瘤杂志2006,4,1: | 17 |
| 2 | Mechanism of sperm capacitation and the acrosome reaction: role of protein kinases显示文摘哺乳动物的精子必须经历一系列生物化学、生理的修正,一起叫的 capacitation,在在 acrosome 反应(AR ) 以前的女繁殖的道。尽管蛋白质 kinases 被显示在 capacitation 和 AR 期间涉及细胞内部的 Ca 2+ 的规定,这些修正的机制很好没被描绘。在现在的评论,我们总结一些涉及 capacitation 的发信号的事件。在 capacitation 过程期间, phosphatidyl-inositol-3-kinase (PI3K ) 是经由一个蛋白质 kinase A (PKA ) 依赖者的 phosphorylated/activated 由蛋白质 kinase C α 的串联,和 downregulated;(PKCα) 。PKCα在 capacitation 的开始是活跃的,导致 PI3K inactivation。在 capacitation 期间, PKCα象 PP1γ 一样; 2 被 PKA 依赖的机制降级,允许 PI3K 的激活。PKA 的激活主要在 capacitation 期间取决于酸式碳酸盐依赖者生产的周期的腺苷 monophosphate (营地) 可溶的 adenylyl cyclase。PKA 的这激活在肌动朊聚合导致增加,必需品为 hyperactivated 活动性的发展处理,它为成功的授精是必要的。肌动朊聚合被果仁 2 以二个方法调停:首先,果仁 2 为 phospholipase D (PLD ) 激活,和秒充当一个余因子,作为绑并且禁止象 gelsolin 那样的切断肌动朊的蛋白质的一个分子。gelsolin 的酷氨酸 phosphorylation 为它的 inactivation 也在由 Src 家庭 kinase (SFK ) 的 capacitation 期间是重要的。在 AR 以前, gelsolin 被免除果仁 2 并且经历 dephosphorylation/activation,导致 AR,导致快 F 肌动朊 depolymerization。 | Debby Ickowicz Maya Finkelstein Haim Breitbart | 2012 | Asian Journal of Andrology2012,14,6: | 17 |
| 3 | 美国学术职业的发展历程显示文摘通过对美国高校教师学术职业历史变迁进行详细、细致、深入的发掘及梳理发现:1800年之前,学院教师是年轻的导师,对学生生活及学习全面负责。19世纪,在工业经济及科学知识大发展的促动下,教师工作实现职业化,即接受长期专门学科学术训练,专门从事教学,从事的社会活动与专业相关,职业晋升路径开始形成。20世纪早期,学术职业巩固且精细化;学术专长被高度认可,教师们争取且获得了范围更广的学术权力;职业晋升路径完善,教师更积极地利用学术专长投身社会事务。1940年至1969年,学术职业群体持续增长且变得更加多样化。1975年至今,教师聘任类型多样化,终身职比例极大缩减,学术职业离心力增大。教师的中心地位遵循着'低-高-低'的钟摆式发展趋势。 | Martin Joel Finkelstein 于汝霜 | 2019 | 高教探索2019,,3: | 5 |
| 4 | 肝细胞癌与肝内胆管癌间基因表型差异分析显示文摘目的:通过对肝细胞癌(HCC)和肝内胆管癌(ICC)之间抑癌基因(tumor suppressor gene,TSG)和微卫星(mi—crosatellite,MS)变异谱特点进行对比分析,了解这两种肝脏最常见恶性肿瘤在基因发生路径上的差异。方法:采用微组织切割法,从石蜡包埋的组织切片中提取基因组DNA进行直接测序,对33例信息性(杂合性)HCC和22例ICC进行了6种TSG杂合性缺失(loss of heterozygosity,LOH)的检测,并对其中10例HCC和全部22例ICC做7个MS的LOH分析。结果:6种TSG的变异情况在HCC依次为:p53(4/5,80.0%)、OGG1(2/4,50.0%)、APC(5/12,41.7%)、RB1(1/5,20.0%)、DCC(0/4,0%)、MCC(0/3,0%);在ICC为:APC(11/16,68.8%)、DCC(6/13,46.2%)、OGG1(5/12,41.7%)、p53(6/16,37.5%)、RB1(2/9,22.2%)、MCC(1/7,14.3%)。HCC和ICC中7个MS的LOH发生率分别为30.0%(3/10)和59.1%(13/22)。7个MS在HCC中仅有2个发生LOH,而在ICC中则全部出现LOH,其中与p16/MTS-1和MXI-1基因连锁的4个MS仅在ICC中出现LOH。结论:HCC和ICC之间TSG和MS存在着明显不同的LOH谱,推测两者在发生过程中可能沿循各自不同的分子路径。对LOH基因谱成员的分析,有助于进一步认识HCC和ICC发生的分子机制。 | 丛文铭 Demetris AJ Finkelstein SD 吴孟超 | 2003 | 第二军医大学学报2003,24,4: | 4 |
| 5 | Breast cancer in China显示文摘 | Lei Fan Kathrin Strasser-Weippl Jun-Jie Li Jessica St Louis Dianne M Finkelstein Ke-Da Yu Wan-Qing Chen Zhi-Ming Shao Paul E Goss | 2014 | Lancet Oncology2014,,7: | 4 |
| 6 | Deceased Donor Split-Liver Transplantation in Adult Recipients: Is the Learning Curve Over?显示文摘 | Ryan P. Cauley Khashayar Vakili Nora Fullington Kristina Potanos Dionne A. Graham Jonathan A. Finkelstein Heung Bae Kim | 2013 | Journal of the American College of Surgeons2013,,: | 2 |
| 7 | What did Medicare do? The initial impact of Medicare on mortality and out of pocket medical spending显示文摘 | Amy Finkelstein Robin McKnight | 2007 | Journal of Public Economics2007,,7: | 2 |
| 8 | Mucin-Producing Neoplasms of the Pancreas: An Analysis of Distinguishing Clinical and Epidemiologic Characteristics显示文摘 | Stefano Crippa Carlos Fernández–del Castillo Roberto Salvia Dianne Finkelstein Claudio Bassi Ismael Domínguez Alona Muzikansky Sarah P. Thayer Massimo Falconi Mari Mino–Kenudson Paola Capelli Gregory Y. Lauwers Stefano Partelli Paolo Pederzoli Andrew L. W | 2010 | Clinical Gastroenterology and Hepatology2010,,2: | 2 |
| 9 | The activation of sulphide minerals for flotation: a review显示文摘 | Finkelstein N P | 1997 | Inter J Miner Process1997,52,: | 2 |
| 10 | Renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man显示文摘 | Smith HW Finkelstein N Aliminosa L | 1945 | J clin Invest1945,24,: | 2 |
| 11 | Back pain and parenthood显示文摘 | Finkelstein MM | 1995 | Occup Environ Med1995,52,1: | 2 |
| 12 | Treatment with Histone Deacetylase Inhibitor Attenuates MAP Kinase Mediated Liver Injury in a Lethal Model of Septic Shock 1显示文摘 | Robert A. Finkelstein Yongqing Li Baoling Liu Fahad Shuja Eugene Fukudome George C. Velmahos Marc deMoya Hasan B. Alam | 2010 | Journal of Surgical Research2010,,1: | 2 |
| 13 | Homocysteine 显示文摘 | Finkelstein JD Martin JJ | 2000 | Int J Biochem Cell Biol2000,32,4: | 1 |
| 14 | Totol homocysteine levels in plasma:high-performance liquid choromatographic determination with electrochemical detection and glassy carbon electrode 显示文摘 | Finkelstein AE Boccazzi FO Fridman O | 1998 | J Chromatogr B1998,720,12: | 1 |
| 15 | New methods for using Cayley Graphs in interconnection networks显示文摘 | Finkelstein L | 1992 | Discrete Applied Math1992,3738,: | 1 |
| 16 | The Aggregate Effects of Health Insurance: Evidence from the Introduction of Medicare显示文摘 | Finkelstein A | 2007 | Quarterly Journal of Medicare2007,122,1: | 1 |
| 17 | Gene type classification of colorectal adenocarcinoma biologic behavior correlates with k-ras-2 muta- tion type显示文摘 | Finkelstein SD Sayegh R Christensen S | 1993 | Cancer1993,71,: | 1 |
| 18 | Large Tcelllym- phomain a 13-year-old with hyperim munoglobulinemia syndrome 显示文摘 | Mossefi R Finkelstein Y Monselize Y | 2002 | Pediatr Allergy Immunol2002,13,2: | 1 |
| 19 | Influence of implantable cardioverter-defibrillators on longterm prognosis of survivors of out-of-hospital cardiac arrest 显示文摘 | Powell AC Fuchs T Finkelstein DM | 1993 | Circulation1993,88,3: | 1 |
| 20 | Chief executive compensation: a study of the intersection of markets and political processes显示文摘 | Finkelstein Sydney Hambrick D | 1989 | Strategic Management Journal1989,10,: | 1 |