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| 1 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 2 | MODIFIED MELT TEXTURING PROCESS FOR YBCO BASED ON THE POLYTHERMIC SECTION YO1.5-BA0.4CU0.6O IN THE Y-BA-CU-O PHASE DIAGRAM AT 0.21 BAR OXYGEN PRESSURE显示文摘 | Krabbes G Schatzle P Bieger W Wiesner U Stover G Wu M Strasser T Litzkendorf D Fischer K Gornert P | | 0，，： | 2 |
| 3 | A new sulfur-fluorine compound,sulfur tetrafluoride(preliminary communication)显示文摘 | Fischer J Jaenckner W | 1929 | Angewandte Chemie1929，42，： | 1 |
| 4 | Cell type specificity of the human endoglin promoter显示文摘 | Guaulich W Nettelbeck D M Fischer D | 1999 | Gene1999，227，1： | 1 |
| 5 | Thermal stresses for frictional contact in wheel-rail system 显示文摘 | Fischer F D Wemer E Yan W Y | 1997 | Wear1997，211，2： | 1 |
| 6 | In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP显示文摘 | Deng W Obrocka M Fischer I | 2001 | Biochem Biophy Res Commun2001，282，1： | 1 |
| 7 | Reducing the peak-to-average power ratio of multicarrier modulation by selected mapping 显示文摘 | R W Bauml R F H Fischer J B Huber | 1996 | Electronics Letters1996，32，22： | 1 |
| 8 | Biodegradable magnesium-hydroxyapatite metal matrix composites显示文摘 | WITTE F FEYERABEND F MAIER P FISCHER J STORMER M BLAWERT C DIETZEL W HORT N | 2007 | Biomaterials2007，28，： | 1 |
| 9 | Absorptive capacity and new product development显示文摘 | Stock G N Greis N P Fischer W A | 2001 | Journal of High Technology Management Research2001，12，1： | 1 |
| 10 | Diarrhea as a risk factor for acute lower respiratory tract infections among young children in low income settings 显示文摘 | Christa L Fischer W Jamie P | 2013 | J Glob Health2013，3，01： | 1 |
| 11 | Interaction of Helicobacter pylori with host cells:function of secreted and translocated molecules 显示文摘 | Rieder G Fischer W Haas R | 2005 | Curr Opin Microbiol2005，8，1： | 1 |
| 12 | In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intraeelleular cyclic AMP显示文摘 | Deng W Obroeka M Fischer I | 2001 | Biochem Biophys Res Commum2001，282，1： | 1 |
| 13 | pH values and redox potentials in microsites of the rhizosphere显示文摘 | Fischer W R Flessa H Schaller G | 1989 | Z Pflanzenernahr Bodenk1989，152，2： | 1 |
| 14 | Molecular genetics of the HLA complex 显示文摘 | Fischer G F Mayr W R | 2001 | Wien Klin Wochenschr2001，113，2021： | 1 |
| 15 | Temperature Dependence of Current Gain in AlGaAs/GaAs Heterojunction Bipolar Transistors显示文摘 | Chand N Fischer R Henderson T Klem J Kopp W and Morkoc H | 1984 | Appl Phys Lett1984，，45： | 1 |
| 16 | Effects of phenolic com-pounds in blueberries and muscadine grapes on HepG2 cellviability and apoptosis 显示文摘 | Yi W Akoh C C Fischer J | 2006 | Food Research International2006，39，5： | 1 |
| 17 | The diagnosis and treatment of hypertensivedisorders of pregnancy 显示文摘 | Rath W Fischer T | 2009 | Dtsch Arztebl Int2009，106，： | 1 |
| 18 | A correlation study of biodegradability determinations with varous chemicals in vatious tests 显示文摘 | Gerike P Fischer W K | 1979 | Eco- toxicology and Environmental Safety1979，3，2： | 1 |
| 19 | Diverse functions of protease receptor tissue factor in inflammation and metastasis显示文摘 | Ruf W Fischer EG Huang HY | | 0，，2： | 1 |
| 20 | Oculomotor bias induced by number perception显示文摘 | Fischer M.H Warlop N Hill R.L Fias W | | 0，，02： | 1 |
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