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| 1 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 2 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 3 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 4 | Ultrapure dialysis fluid slows loss of residual renal function in new dialysis patients.显示文摘 | Schiffl H Lang SM Fischer R | | 0，，： | 3 |
| 5 | Plant Productivity in the Arid and Semiarid Zones显示文摘 | R A Fischer N C Turner | 1978 | Annual Review of Plant Physiology1978，，： | 3 |
| 6 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 7 | Perioperative outcomes of major hepatic resections under low central venous pressure anesthesia: blood loss, blood transfusion, and the risk of postoperative renal dysfunction显示文摘 | Jose A Melendez Vittoria Arslan Mary E Fischer David Wuest William R Jarnagin Yuman Fong Leslie H Blumgart | 1998 | Journal of the American College of Surgeons1998，，6： | 2 |
| 8 | Present state of the comparison between radiometric scales based on three primary standards显示文摘 | STOCK M FISCHER J FRIEDRICH R | 1993 | Metrologia1993，30，： | 2 |
| 9 | Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy显示文摘 | Fischer R McGhee JR Vu HL | 2005 | Am J Pathol2005，167，6： | 1 |
| 10 | Stem cell division is regulated by the microRNA pathway显示文摘 | HATFIELD S D SHCHERBATA H R FISCHER K A | 2005 | Nature2005，435，7044： | 1 |
| 11 | High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein显示文摘 | Hartmann G Tschop M Fischer R | 2002 | Cytokine2002，12，3： | 1 |
| 12 | Environmental and technology policies for climate mitigation 显示文摘 | Fischer C Newell R G | 2008 | Journal of Environmental Economics and Management2008，55，： | 1 |
| 13 | Reducing the peak-to-average power ratio of multicarrier modulation by selected mapping 显示文摘 | R W Bauml R F H Fischer J B Huber | 1996 | Electronics Letters1996，32，22： | 1 |
| 14 | Thermogravimetric characteriza- tion of gelcast alumina composites显示文摘 | Dweck J Fischer R Fischer E | 1997 | Journal of Thermal Analys- is and Calorimetry1997，49，3： | 1 |
| 15 | FDG avidity and PET/CT patterns in primary gastric lymphoma显示文摘 | Radan L Fischer D Bar-Shalom R | 2008 | Eur J Nucl Med MolImaging2008，35，8： | 1 |
| 16 | Stereospecificity of phenylalanine plasma kinetics and hydroxylation in nmn following oral application of a stable isotope-labelled pseudo-racemic mixture of L-and D-phenylalanine 显示文摘 | Lehmmm WD Theobald N Fischer R | 1993 | Clin Chim Acta1993，128，2： | 1 |
| 17 | Performed tobacco-specific nitrosamines in tobacco role nitrate and influence of tobacco type显示文摘 | Fischer S Spiegelhalder B Preussmann R | 1984 | Carcin ogenesis1984，10，8： | 1 |
| 18 | 显示文摘 | Fischer R Schrefl T Kronmüller H | 1996 | J Magn Magn Mater1996，153，： | 1 |
| 19 | Molecular farming of pharmaceutical Proteins显示文摘 | Fischer R Emans N | 2000 | Transgenic Res2000，9，： | 1 |
| 20 | Molecular farming of pharmaceutical proteins 显示文摘 | FISCHER R EMANS N | 2000 | Transgenic Research2000，9，： | 1 |
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