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| 1 | Acute-on-chronic liver failure: Controversies and consensus显示文摘Acute-on-chronic liver failure(ACLF)is a poorly defined syndrome characterised by rapid clinical deterioration in patients with chronic liver disease.Consequences include high short-term morbidity,mortality,and healthcare resource utilisation.ACLF encompasses a dysregulated,systemic inflammatory response,which can precipitate extra hepatic organ failures.Common precipitants include infection,alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is identified.Heterogenous definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology societies.This can result in delayed or missed diagnoses of ACLF,significant variability in clinical management,and under-estimation of disease burden.Liver transplantation may be considered but the mainstay of treatment is organ support,often in the intensive care unit.This review will provide clarity around where are the controversies and consensus in ACLF including:Epidemiology and resource utilisation,key clinical and diagnostic features,strategies for management,and research gaps. | Natalie L Y Ngu Eliza Flanagan Sally Bell Suong T Le | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 2 | Effects of substrate stiffness on cell morphology, cytoskeletal structure and adhesion 显示文摘 | Yeung T Georges P C Flanagan L Av | 2005 | Cell Motol Cytoskel2005，60，1： | 1 |
| 3 | Finite element evaluation of hydrogen solubility enhancements due to thermal residual stresses in palladium-alumina composites显示文摘 | Dixit P M Balasubramaniam R Flanagan T B | 2003 | J Alloys and Compounds2003，，： | 1 |
| 4 | Tear meniscus height determination using the OCT2 and the RTVue-100 显示文摘 | Keech A Flanagan J Simpson T | 2009 | Optom Vis Sci2009，86，： | 1 |
| 5 | Hydrogen isotherms for following the interna oxidation of ternary Pd alloys显示文摘 | Wang D Flanagan T B | 2000 | Scr Mater2000，42，： | 1 |
| 6 | The thermodynamics of hydrogen in palladium carbon alloys显示文摘 | Kishimoto S Flanagan T B | 1985 | Zeitschrift für Physikalische Chemie1985，，： | 1 |
| 7 | Hydrogen induced lattice migration in Pd-Pt alloy显示文摘 | Flanagan T B Clewley J D Noh H | 1998 | Acta Mater1998，46，： | 1 |
| 8 | The influence of insulin on circulating ghrelin显示文摘 | FLANAGAN D E EVANS M L MONSOD T P | 2003 | Metab2003，284，2： | 1 |
| 9 | Assessing water erosion in small watersheds using WEPP with GIS and digital elevation models显示文摘 | Cochrane T A Flanagan D C | 1999 | Soil and Water Conservation1999，54，4： | 1 |
| 10 | Representativehillslope methods for applying the WEPP model withDEMS and GIS显示文摘 | COCHRANE T A FLANAGAN D C | 2003 | Transactions of the ASAE2003，46，4： | 1 |
| 11 | Application of high-power lasers in electronic assembly显示文摘 | Flanagan A Connely A Glynn T J | 1996 | Key Eng Material1996，118，119： | 1 |
| 12 | Laser soldering andinspection of fine pitch electronic components显示文摘 | Flanagan A Conneely A Glynn T J | 1996 | Journal of Material Processing Technology1996，56，14： | 1 |
| 13 | A umform strain hexahedron and quadrilateral with orthogonal hour glass control显示文摘 | Flanagan D P Belytschko T | 1981 | Int J Numer Meth Engng1981，17，5： | 1 |
| 14 | Low frequency magnetoresistive noise in spin-valve structures 显示文摘 | Ozbay A Gokce A Flanagan T | 2009 | Appl Phys Lett2009，94，20： | 1 |
| 15 | Discrimination against C^18O^16 O during photosynthesis and oxygen isotopic ratio of respired CO2 in boreal forest ecosystem显示文摘 | Flanagan L B Brooks J R Varney G T | 1997 | Global Biogeochemical Cycles1997，11，1： | 1 |
| 16 | Assessing water erosion in small watersheds using WEPP with GIS and digital elevation models显示文摘 | Cochrane T A Flanagan D C | 1999 | J Soil and Water Conserv1999，54，4： | 1 |
| 17 | Orchid diversity-beyond deception显示文摘 | Otero J T Flanagan N S | 2006 | Trends in Ecology & Evolution2006，21，： | 1 |
| 18 | Properties of lipoamino acids incorporated into membrane bilayers显示文摘 | EPAND R F INFANTE M R FLANAGAN T D | 1998 | Biochimica Et Biophysica Acta1998，1373，1： | 1 |
| 19 | Purification and characterization of D-xylulokinase from the pentose-fermenting yeast Pichia stipitis NCYC-1541显示文摘 | Flanagan T Waites M J | 1992 | Enzyme Microb Technol1992，14，12： | 1 |
| 20 | Carbon isotope discrimination during photosynthesis and the isotope radio of respired CO2 in boreal forest ecosystem显示文摘 | Flanagan L B Brooks J R Vamey G T | 1996 | Global Biogeochemical Cycles1996，10，4： | 1 |
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