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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Enamel microabrasion: An overview of clinical and scientific considerations显示文摘Superficial stains and irregularities of the enamelare generally what prompt patients to seek dental intervention to improve their smile. These stains or defects may be due to hypoplasia, amelogenesis imperfecta, mineralized white spots, or fluorosis, for which enamel microabrasion is primarily indicated. Enamel microabrasion involves the use of acidic and abrasive agents, such as with 37% phosphoric acid and pumice or 6% hydrochloric acid and silica, applied to the altered enamel surface with mechanical pressure from a rubber cup coupled to a rotatory mandrel of a lowrotation micromotor. If necessary, this treatment can be safely combined with bleaching for better esthetic results. Recent studies show that microabrasion is a conservative treatment when the enamel wear is minimal and clinically imperceptible. The most important factor contributing to the success of enamel microabrasion is the depth of the defect, as deeper, opaque stains, such as those resulting from hypoplasia, cannot be resolved with microabrasion, and require a restorative approach. Surface enamel alterations that result from microabrasion, such as roughness and microhardness, are easily restored by saliva. Clinical studies support the efficacy and longevity of this safe and minimally invasive treatment. The present article presents the clinical and scientific aspects concerning the microabrasion technique, and discusses the indications for and effects of the treatment, including recent works describing microscopic and clinical evaluations. | Núbia Inocencya Pavesi Pini Daniel Sundfeld-Neto Flavio Henrique Baggio Aguiar Renato Herman Sundfeld Luis Roberto Marcondes Martins José Roberto Lovadino Débora Alves Nunes Leite Lima | 2015 | World Journal of Clinical Cases2015，3，1： | 6 |
| 3 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 4 | Sense of Belonging in School as a Protective Factor Against Drug Abuse Among Native American Urban Adolescents显示文摘 | Maria N Flavio FM Stephen K | 2003 | Journal of Social Work Practice in the Addietions2003，3，2： | 1 |
| 5 | Optimising monitoring in the management of Crohn’s disease: A physician’s perspective显示文摘 | Pavol Papay Ana Ignjatovic Konstantinos Karmiris Heda Amarante Pal Milheller Brian Feagan Geert D’Haens Philippe Marteau Walter Reinisch Andreas Sturm Flavio Steinwurz Laurence Egan Julián Panés Edouard Louis Jean-Frédéric Colombel Remo Panaccione | 2013 | Journal of Crohn’s and Colitis2013，，： | 1 |
| 6 | Hepatic cholesterol transport from plama into bile:implications for gallstone disease显示文摘 | Silvarm Z Attilio R Flavio N | 2004 | Curt Opin Lipidol2004，15，3： | 1 |
| 7 | Participatory landrace selection for on-farm conservation: An example from the Central Valleys of Oaxaca, Mexico显示文摘 | Mauricio R. Bellon Julien Berthaud Melinda Smale José Alfonso Aguirre Suketoshi Taba Flavio Aragón Jaime Díaz Humberto Castro | 2003 | Genetic Resources and Crop Evolution2003，，4： | 1 |
| 8 | Temporal synchronization of non-overlapping videosusing known object motion显示文摘 | Darlan N Brito Flavio L C Padua Guilherme A S PereiraL | 2011 | Pattern Recognition Letters2011，32，1： | 1 |
| 9 | Optical recognition of motor vehicle license plate显示文摘 | Paolo F Mario N G Flavio S | 1995 | Transactions on Vehicle Technology1995，44，4： | 1 |
| 10 | Clinicopathological findings and results of surgical treatment in cardiac adenocarcinoma显示文摘 | Lorenzo B Gabriella N Flavio M | 2000 | J Surgical Oncology2000，74，2： | 1 |
| 11 | Adaptive output feedback control of uncertain nonlinear systems using single-hidden-layer neural networks显示文摘 | NAIRA H FLAVIO N KIM N | 2002 | IEEE Trans on Neural Networks2002，13，6： | 1 |
| 12 | A novel error observer-based adaptive output feedback approach for control of uncertain systems显示文摘 | NAIRA H FLAVIO N CALISE A | 2002 | IEEE Transactions on Automatic Control2002，47，8： | 1 |
| 13 | Adaptive output feedback control of uncertain nonlinear systems using single-Hiddenlayer neural networks显示文摘 | NAIRA H FLAVIO N CALISE A | 2002 | IEEE Transactions on Neural Networks2002，13，6： | 1 |
| 14 | Startup of a distillation column using intelligent control techniques显示文摘 | JOAO A E ARRUDA L V R FLAVIO N J | 2005 | Computers and Chemical Engineering2005，30，2： | 1 |
| 15 | A Recur sive Least Square Adaptive Filter for Nonuniformity Correc tion of Infrared Image Sequences显示文摘 | Flavio Torres Sergio N Torres Cesar San Martin | 2005 | Lecture Notes in Com puter Science2005，3773，： | 1 |
| 16 | Optical chaotic communication using generalized and complete synchronization 显示文摘 | PISARCHIK A N FLAVIO R Ruiz-Oliveras | 2010 | IEEE journal of quantum electronics2010，46，3： | 1 |
| 17 | 乌拉圭的自然保护地体系——发展与保护相协同显示文摘目前,乌拉圭已建成国家自然保护地体系(El Sistema Nacional de Áreas Protegidas,简称SNAP),其已成为协调环境保护(特别是自然景观、生态系统、物种和文化要素多样性)与经济社会发展的基础工具。该体系通过娱乐、旅游、教育和研究,以及开发与自然保护相适应的富有成效的活动,为自然保护地所在社区和整个社会创造安居乐业的机会。 | 先义杰(文) Flavio Toti Monzón(图) | 2022 | 人与生物圈2022，，4： | 0 |
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