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| 1 | Levels of insecticide resistance to deltamethrin,malathion,and temephos,and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands(French West Indies)显示文摘Background:In the Guadeloupe and Saint Martin islands,Aedes aegypti mosquitoes are the only recognized vectors of dengue,chikungunya,and Zika viruses.For around 40 years,malathion was used as a mosquito adulticide and temephos as a larvicide.Since the European Union banned the use of these two insecticide molecules in the first decade of the 21st century,deltamethrin and Bacillus thuringiensis var.israelensis are the remaining adulticide and larvicide,respectively,used in Guadeloupe.In order to improve the management of vector control activities in Guadeloupe and Saint Martin,we investigated Ae.aegypti resistance to and mechanisms associated with deltamethrin,malathion,and temephos.Methods:Ae.aegypti mosquitoes were collected from six different localities of Guadeloupe and Saint Martin.Larvae were used for malathion and temephos bioassays,and adult mosquitoes for deltamethrin bioassays,following World Health Organization recommendations.Knockdown resistance(Kdr)genotyping for V1016I and F1534C mutations,and expression levels of eight enzymes involved in detoxification mechanisms were examined in comparison with the susceptible reference Bora Bora strain.Results:Resistance ratios(RR50)calculated for Ae.aegypti larvae showed high resistance levels to temephos(from 8.9 to 33.1-fold)and low resistance levels to malathion(from 1.7 to 4.4-fold).Adult females displayed moderate resistance levels to deltamethrin regarding the time necessary to affect 50%of individuals,varying from 8.0 to 28.1-fold.Molecular investigations on adult mosquitoes showed high resistant allele frequencies for V1016I and F1534C(from 85 to 96%and from 90 to 98%,respectively),as well as an overexpression of the glutathione S-transferase gene,GSTe2,the carboxylesterase CCEae3a,and the cytochrome genes 014614,CYP6BB2,CYP6M11,and CYP9J23.Conclusions:Ae.aegypti populations from Guadeloupe and Saint Martin exhibit multiple resistance to organophosphates(temephos and malathion),and pyrethroids(deltamethrin).The mechanisms associated with these resistance patterns show strong frequencies of F1534C and V1016I Kdr mutations,and an over-expression of CCEae3a,GSTe2,and four cytochrome P450 genes(014614,CYP9J23,CYP6M11,CYP6BB2).These results will form the baseline for a deeper understanding of the insecticide resistance levels and associated mechanisms of Ae.aegypti populations and will be used to improve vector control strategies in Guadeloupe and Saint Martin. | Daniella Goindin Christelle Delannay Andric Gelasse Cedric Ramdini Thierry Gaude Frederic Faucon Jean-Philippe David Joël Gustave Anubis Vega-Rua Florence Fouque | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 2 | Percutaneous absorption of inorganic lead compounds显示文摘 | Stauber J L Florence T M Gulson G L | 1994 | Sci Total Environ1994，145，： | 1 |
| 3 | The Effect of culture-medium on metal toxicity to the marine diatom Nitzschia-closterium and the fresh-water green-alga Chlorella-pyrenoidosa 显示文摘 | STAUBER J L FLORENCE T M | 1989 | Water Res1989，23，7： | 1 |
| 4 | Thermoelastic stress due to disturbance of uniform heat flow by an insulated ovaloid hole显示文摘 | FLORENCE A L GOODIER J N | 1960 | ASME Journal of Applied Mechanics1960，82，： | 1 |
| 5 | Dynamic triaxial tests of high strength concrete显示文摘 | Gran J K Florence A L Colton J D | 1989 | Journal of Engineering Mechanics ASCE1989，115，5： | 1 |
| 6 | New formulation of vasoactive intestinal peptide using liposomes in hyaluronic acid gel for uveitis显示文摘 | Laure L Serge C Florence A | 2009 | J Contr Release2009，139，1： | 1 |
| 7 | The preparation and properties of niosomes-non-ionic surfactant vesicles显示文摘 | Baillie A J Florence A T Hume L R | 1985 | J Pharm Pharmacol1985，37，12： | 1 |
| 8 | Dynamic triaxial test of high-strength concrete显示文摘 | Gran J K Florence A L Colton J D | 1989 | Journal of Engineering Mechanics1989，115，5： | 1 |
| 9 | Bioavailability of Al in alum-treated drinking water 显示文摘 | Stauber J L Florence T M Davies C M | 1999 | J Am Water Works Assoc1999，91，： | 1 |
| 10 | 查看详情显示文摘 | G M Espallargas L Brammer J van de Streek K Shankland A J Florence H Adams | | 0，，： | 1 |
| 11 | Absence of a prominent Th2 cytokine response in human tuberculosis显示文摘 | Yuanguang L Ming ZH Florence MH | 1996 | Infect Immun1996，64，4： | 1 |
| 12 | Drug release mechanisms from ethylcellulose: PVA-PEG graft copolymer-coated pellets 显示文摘 | Susanne M Florence S Bruno L | 2009 | Eur J Pharm Biopharm2009，72，1： | 1 |
| 13 | The placenta: a main role in congenital toxoplasmosis?显示文摘 | Florence Robert-Gangneux Jean-Benjamin Murat Hélène Fricker-Hidalgo Marie-Pierre Brenier-Pinchart Jean-Pierre Gangneux Hervé Pelloux | 2011 | Trends in Parasitology2011，，12： | 1 |
| 14 | A new polymorphism in the ApoE promoter associ-ated with risk of developing Alzheimer′s Disease显示文摘 | Jean-chaarles L Florence P Dominique C | 1998 | Human Molecular Genetics1998，7，3： | 1 |
| 15 | Thermal stresses due to disturbance of uniform heat flow by an insulated ovaloid hote显示文摘 | Florence A L Goodier J N | 1960 | Journal Applied Mechanics1960，27，4： | 1 |
| 16 | Dynamic triaxial test of high strength concrete显示文摘 | Gran J K Florence A L | 1989 | Journal of Engineering Mechanics1989，115，5： | 1 |
| 17 | Evidence ofpresence of poliovirus genomic sequences in cerebrospinal fluidfrom patients with postpolio syndrome显示文摘 | ISABELLE L G JEAN J FLORENCE F | 1996 | Clin Microbiology1996，34，： | 1 |
| 18 | Aluminum bioavailability from tea infusion 显示文摘 | YOKEL R A FLORENCE R L | 2008 | Food Chem Toxicol2008，46，12： | 1 |
| 19 | Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders显示文摘 | Eider M. Arenaza-Urquijo Brigitte Landeau Renaud La Joie Katell Mevel Florence Mézenge Audrey Perrotin Béatrice Desgranges David Bartrés-Faz Francis Eustache Ga?l Chételat | 2013 | Neuroimage2013，，： | 1 |
| 20 | Incremental Support Vector Machine Learning: A Local Approach 显示文摘 | Ralaivola L Florence d' Alch6-Buc | 2001 | ICANN2001，，： | 1 |
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