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| 1 | Physico-chemical and mechanical properties of Ti_3SiC_2-based materials elaborated from SiC/Ti by reactive spark plasma sintering显示文摘In this paper, the synthesis of Ti_3 SiC_2 from SiC/Ti powder using reactive spark plasma sintering(R-SPS) in the temperature range of 1300-1400 ℃ is reported. The results show that the purity of Ti_3 SiC_2 is improved up to 75 wt% when the holding time is increased from 10 to 20 min at1400 ℃. The thermodynamic and experimental results indicate that Ti_3 SiC_2 formation takes place via the reaction of a pre-formed TiC phase with the silicides, formed from the eutectic compositions.Detailed analysis of mechanical behaviour indicates that samples with higher percentage of secondary phases exhibit higher microhardness and better resistance compared to the near single phase Ti_3 SiC_2. | Faten TURKI Houyem ABDERRAZAK Frédéric SCHOENSTEIN Florent TêTARD Mohieddine ABDELLAOUI Noureddine JOUINI | 2019 | Journal of Advanced Ceramics2019，8，1： | 2 |
| 2 | Prevalence and risk factors for adenomas in the ileal pouch and the afferent loop after restorative proctocolectomy for patients with familial adenomatous polyposis显示文摘 | Elise Pommaret Ariane Vienne Jérémie H. Lefevre Philippe Sogni Christian Florent Beno?t Desaint Yann Parc | 2013 | Surgical Endoscopy2013，，10： | 1 |
| 3 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCYI, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance 显示文摘 | Papon N Noel T Florent M | 2007 | Antimicrob Agents Chemother2007，51，1： | 1 |
| 4 | Flow maldist- tribution in heat exchangers 显示文摘 | LALO T FLORENT P LANG S K | 1999 | Applied Thermal Engi- neering1999，19，5： | 1 |
| 5 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 6 | Molecular mechanism of flucytosine resistance in Candida lusitaniae:Contribution of the FCY2,FCY1,and FURl genes to 5-fluorouracil and fluconazole crossresistance显示文摘 | Papon N Noel T Florent M | 2007 | Antimicrob Agents Chemother2007，51，1： | 1 |
| 7 | Non- sense and missense mutations in FCY2 and FCY1 genes are responsible for flueytosine resistance and flucytosine-flueonazole cross-resistance in clinical i- solates of Candida lusitaniae显示文摘 | Florent M Noel T Ruprich-Robert G | 2009 | Antimicrob Agents Chemother2009，53，7： | 1 |
| 8 | Risk models based on time series for count random variables显示文摘 | Helene C Etienne M Florent T | 2011 | Insurance:Mathematics and Economics2011，48，： | 1 |
| 9 | Multiplication and cryopreservation of vanilla (Vanilla planifolia 'Andrews') 显示文摘 | Maria T G A Claudia E L V Florent E | 2009 | In Vitro Cell Dev Biol-Plant2009，45，5： | 1 |
| 10 | Molecular mechanism of flucytosine resistance in Candida lusitaniae: contribution of the FCY2, FCY1, and FUR1 genes to 5-fluorouracil and fluconazole cross-resistance显示文摘 | Papon N Noel T Florent M | 2007 | Antimicrobial Agents and Chemotherapy2007，51，1： | 1 |
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