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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Current status of rabies and prospects for elimination 显示文摘 | Fooks A R Banyard A C Horton D L | 2014 | Lancet2014，384，9951： | 1 |
| 3 | The effect of acupuncture on motor cortex excitability and plasticity显示文摘 | Yew Long Lo Cui S L Chong S Fook | 2005 | Neuroscience Letters2005，384，： | 1 |
| 4 | Mixed culture fermentation studies on the effects of synbiotics on the human intestinal pathogens Campylobacterjejuni and Escherichia coli显示文摘 | Fooks L J Gibson G R | 2003 | Anaerobe2003，9，： | 1 |
| 5 | Prebiotics, probiotics and human gut microbiology显示文摘 | FOOKS L J FULLER R GIBSON G R | 1999 | Dairy J1999，5，9： | 1 |
| 6 | Cannine vaccinerecipients recognize an immunodomiant region of the rabies virus glycoprotein显示文摘 | Johson N Mansfield K L Fooks A R | 2002 | J Gen Virol2002，83，11： | 1 |
| 7 | Prebiotics, Probiotics and human gut microbiology 显示文摘 | Fooks L J Fuller R Gibson G R | 1999 | International Dairy Journal1999，9，1： | 1 |
| 8 | Probiotics as modulators of the gut flora显示文摘 | FOOKS L J GIBSON G R | 2002 | Br J Nutr2002，88，1： | 1 |
| 9 | The challenge of managing mid-foot pain显示文摘 | Baquie P Fooks L Pope J | 2015 | Aust Fam Physician2015，44，3： | 1 |
| 10 | Results, experience and technical points learnt with use of the SKy Bone Expander kyphoplasty system for osteoporotic vertebral compression fractures: a prospective study of 40 patients with a minimum of 12 months of follow-up显示文摘 | Foo L S Yeo W Fook S | 2007 | Eur Spine J2007，16，： | 1 |
| 11 | Breast ultrasound in women with familial risk of breast cancer显示文摘 | Sim L S Hendriks J H Fook Chong S M | 2004 | Ann Acad Med Singapore2004，33，： | 1 |
| 12 | Inferior rabies vac-cine quality and low immunization coverage in dogs(Canis famil-iaris)in China显示文摘 | HU R L A R Fooks A R Zhang S F | 2008 | Epidemiology and infection2008，136，11： | 1 |
| 13 | Prebiotics, probiotics and human gut microbiology显示文摘 | FOOKS L J FULLER R GIBSON G R | 1999 | Int Dairy J1999，9，1： | 1 |
| 14 | Results,experience and technical points learnt with use of the SKy Bone Expander kyphoplasty system for osteoporotic vertebral compression fractures:a prospective study of 40 patients with a minimum of 12 months of follow-up显示文摘 | Foo L S Yeo W Fook S | 2007 | Eur Spine J2007，16，11： | 1 |
| 15 | Lesson of the week:Oxybutynin and cognitive dysfunction显示文摘 | Donnellan CA Fook L McDonald P | 1997 | BMJ1997，315，7119： | 1 |
| 16 | Methods for assessing the potential of prebiotics and probiotics显示文摘 | RYCROFT C E FOOKS L J GIBSON G R | 1999 | Curr Opin Clin Nutr Metab Care1999，2，6： | 1 |
| 17 | Prebiotics, probiotics and human gut microbiology 显示文摘 | Fooks L J Full R Gibson G R | 1999 | Int Dairy J1999，9，： | 1 |
| 18 | Probiotics as modulator of the gut flora显示文摘 | Fooks L Gibson G R | 2002 | Br J Nutr2002，88，1： | 1 |
| 19 | Probiotics as modulators of the gut flor显示文摘 | FOOKS L J GIBSON G R | | 0，，1： | 1 |
| 20 | Probiotics and human gut mierobiology显示文摘 | Fooks L J Fuller R Gibson G R | 1999 | Int Dairy J1999，，9： | 1 |
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