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| 1 | Two quantitative trait loci, Dw1 and Dw2, are primarily responsible for rootstock-induced dwarfing in apple显示文摘The apple dwarfing rootstock‘Malling9’(‘M9’)has been used worldwide both to reduce scion vigour and as a genetic source for breeding new rootstocks.Progeny of‘M9’segregate for rootstock-induced dwarfing of the scion,indicating that this trait is controlled by one or more genetic factors.A quantitative trait locus(QTL)analysis of a rootstock population derived from the cross between‘M9’בRobusta5’(non-dwarfing)and grafted with‘Braeburn’scions identified a major QTL(Dw1)on linkage group(LG)5,which exhibits a significant influence on dwarfing of the scion.A smaller-effect QTL affecting dwarfing(Dw2)was identified on LG11,and four minor-effect QTLs were found on LG6,LG9,LG10 and LG12.Phenotypic analysis indicates that the combination of Dw1 and Dw2 has the strongest influence on rootstock-induced dwarfing,and that Dw1 has a stronger effect than Dw2.Genetic markers linked to Dw1 and Dw2 were screened over 41 rootstock accessions that confer a range of effects on scion growth.The majority of the dwarfing and semi-dwarfing rootstock accessions screened carried marker alleles linked to Dw1 and Dw2.This suggests that most apple dwarfing rootstocks have been derived from the same genetic source. | Toshi M Foster Jean-Marc Celton David Chagné D Stuart Tustin Susan E Gardiner | 2015 | Horticulture Research2015，2，1： | 10 |
| 2 | Total pancreatectomy and islet autotransplantation: A decade nationwide analysis显示文摘AIM: To investigate outcomes and predictors of inhospital morbidity and mortality after total pancreatectomy(TP) and islet autotransplantation. METHODS: The nationwide inpatient sample(NIS) database was used to identify patients who underwent TP and islet autotransplantation(IAT) between 2002-2012 in the United States. Variables of interest were inherent variables of NIS database which included demographic data(age, sex, and race), comorbidities(such as diabetes mellitus, hypertension, and deficiency anemia), and admission type(elective vs nonelective). The primary endpoints were mortality and postoperative complications according to the ICD-9 diagnosis codes which were reported as the second to 25 th diagnosis of patients in the database. Risk adjusted analysis was performed to investigate morbidity predictors. Multivariate regression analysis was used to identify predictors of in-hospital morbidity.RESULTS: We evaluated a total of 923 patients who underwent IAT after pancreatectomy during 2002-2012. Among them, there were 754 patients who had TP + IAT. The most common indication ofsurgery was chronic pancreatitis(86%) followed by acute pancreatitis(12%). The number of patients undergoing TP + IAT annually significantly increased during the 11 years of study from 53 cases in 2002 to 155 cases in 2012. Overall mortality and morbidity of patients were 0% and 57.8 %, respectively. Postsurgical hypoinsulinemia was reported in 42.3% of patients, indicating that 57.7% of patients were insulin independent during hospitalization. Predictors of inhospital morbidity were obesity [adjusted odds ratio(AOR): 3.02, P = 0.01], fluid and electrolyte disorders(AOR: 2.71, P < 0.01), alcohol abuse(AOR: 2.63, P < 0.01), and weight loss(AOR: 2.43, P < 0.01). CONCLUSION: TP + IAT is a safe procedure with no mortality, acceptable morbidity, and achieved high rate of early insulin independence. Obesity is the most significant predictor of in-hospital morbidity. | Reza Fazlalizadeh Zhobin Moghadamyeghaneh Aram N Demirjian David K Imagawa Clarence E Foster Jonathan R Lakey Michael J Stamos Hirohito Ichii | 2016 | World Journal of Transplantation2016，6，1： | 9 |
| 3 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 4 | Chemoradiation with 5-fluorouracil and mitomycin C in the treatment of vulvar squamous cell carcinoma显示文摘 | Mulayim N Foster Silver D Schwartz P E | 2004 | Gynecol Oncol2004，93，3： | 2 |
| 5 | Oxidation products formed from gaseous alkane by the bacterium Pseudomonas metharica 显示文摘 | Leadbetter E R Foster J W | 1959 | Arch Biochem Biophys1959，82，： | 1 |
| 6 | Three-dimen-sional trans-abdominal ultrasound identification of aortic plaque显示文摘 | Foster E Heidenreich P | 1995 | Am J Card Imaging1995，9，4： | 1 |
| 7 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 8 | Impact of tricuspid regurgitation on long-term survival显示文摘 | Nath J Foster E Heidenreich P A | 2004 | J Am Coll Cardid2004，43，3： | 1 |
| 9 | Recommend- ations for evaluation of the severity of native valvular reg-urgitation with two-dimensional Doppler Echocardiography 显示文摘 | Zoghbi W A Enriquez-Sarano M Foster E | 2003 | J Am Soc Echocardiogr2003，16，7： | 1 |
| 10 | New untwist on diastole: what goes around comes back显示文摘 | Foster E Lease KE | 2006 | Circulation2006，113，21： | 1 |
| 11 | Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients with cystic fibrosis显示文摘 | Mahenthiralingam E Campbell M E Foster J | 1996 | J Clin Microbiol1996，34，5： | 1 |
| 12 | Health and safety implication of exposure to electromagnetic fields in the frequency range 300Hz to 10 MHz 显示文摘 | Foster KR Repacholi MH | 2002 | Bioelectromagnetics2002，23，1： | 1 |
| 13 | Poetry in general practice education: Per- ceptions of learners显示文摘 | Foster W Freeman E | 2008 | Fam pract2008，25，4： | 1 |
| 14 | Surbibal in malignant peripheral nerve sheath tumours: a comparison between sporadic and neurofibromatosis type I-Associated tumours 显示文摘 | PORTER D E PRASAD V FOSTER L | 2009 | Sarcoma2009，2009，75： | 1 |
| 15 | In vitro analysis of the anthelmintle axtivity of forage chicory (Cichorium intybus L) sesquiterpene laxtones against a predominatly Haemonchus contortus egg population 显示文摘 | Foster J G Cassida K A Turner K E | 2011 | Veterinary Parasitology2011，180，34： | 1 |
| 16 | Australia's search for petroleum: patterns of discovery显示文摘 | Bradshaw M T Foster C B Fellows M E & Rowland D C | 1999 | Oil & Gas Journal1999，97，23： | 1 |
| 17 | Highly bioactive silver and silver/titania composite films grown by chemical vapour deposition显示文摘 | Brook L A Evans P Foster H A Pemble M E | 2007 | Journal of Photochemistry and Photobiology A:Chemistry2007，187，1： | 1 |
| 18 | An engineering analysis of plastic wave propagation in the Taylor test显示文摘 | Jones S E Maudlin P J Foster Jr J C | 1998 | International Journal Impact Engineering1998，20，2： | 1 |
| 19 | Difficult Supracondylar Elbow Fractures in Children;Analysis of Percutaneous Pinning Technique显示文摘 | KALLIO P E FOSTER B K PATERSON D C | 1992 | J Pediatr Orthop1992，12，： | 1 |
| 20 | Representing virtual data:a metadata architecture for location and materialization transparency显示文摘 | DEELMAN E FOSTER I KESSELMAN C | 2001 | Technical Report Griphy2001，，4： | 1 |
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