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| 1 | Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis显示文摘Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone.Biomineralization is regulated by the ratio of inorganic phosphate(Pi) to mineral inhibitor pyrophosphate(PPi), where local Piand PPi concentrations are controlled by phosphatases including tissue-nonspecific alkaline phosphatase(TNAP) and ectonucleotide pyrophosphatase/phosphodiesterase 1(NPP1). The focus of this study was to define the roles of these phosphatases in cementogenesis. TNAP was associated with earliest cementoblasts near forming acellular and cellular cementum. With loss of TNAP in the Alpl null mouse, acellular cementum was inhibited, while cellular cementum production increased, albeit as hypomineralized cementoid. In contrast, NPP1 was detected in cementoblasts after acellular cementum formation, and at low levels around cellular cementum. Loss of NPP1 in the Enpp1 null mouse increased acellular cementum, with little effect on cellular cementum.Developmental patterns were recapitulated in a mouse model for acellular cementum regeneration, with early TNAP expression and later NPP1 expression. In vitro, cementoblasts expressed Alpl gene/protein early, whereas Enpp1 gene/protein expression was significantly induced only under mineralization conditions. These patterns were confirmed in human teeth, including widespread TNAP, and NPP1 restricted to cementoblasts lining acellular cementum. These studies suggest that early TNAP expression creates a low PPienvironment promoting acellular cementum initiation, while later NPP1 expression increases PPi, restricting acellular cementum apposition. Alterations in PPihave little effect on cellular cementum formation, though matrix mineralization is affected. | Laura E Zweifler Mudita K Patel Francisco H Nociti Jr Helen F Wimer Jose L Milln Martha J Somerman Brian L Foster | 2015 | International Journal of Oral Science2015，7，1： | 5 |
| 2 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 3 | Chitosan-van- comysin composite biomaterial as a laser activated surgical adhesive with regional antimicrobial activity显示文摘 | Foster LJ Thomson K Marcal H | 2010 | Biomacro- molecules2010，11，12： | 1 |
| 4 | Mathematical representation of solute solubility in supercritical carbon dioxide using empirical expression 显示文摘 | JOUYBAN A CHAN H K FOSTER N R | 2002 | Journal of Supercritical Fluids2002，24，： | 1 |
| 5 | J Chem Soc显示文摘 | Baggett N Buck K W Foster A B Randall M H Webber J M | 1965 | :33941965，，： | 1 |
| 6 | Effects of feeding diets containing Fusarium(naturally) contaminated wheat or pure deoxynivalenol(DON) in growing pigs显示文摘 | Trenholm H L Thompson B K Foster B C et a/ | 1994 | Anim Sci1994，74，2： | 1 |
| 7 | Targeting eosinophils in asthma显示文摘 | FOSTER P S ROSENBERG H F ASQUITH K L | 2008 | Curr Mol Med2008，8，6： | 1 |
| 8 | Regulation of mTOR complex 1 (mTORCl) by raptorSer863 and multisite phosphorylation显示文摘 | Foster K G Acosta-Jaquez H A Romeo Y | 2010 | J Biol Chem2010，285，1： | 1 |
| 9 | Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells 显示文摘 | SHINKAI M FOSTER G H RUBIN B K | 2006 | Am J Physiol Lung Cell Mol Physiol2006，290，1： | 1 |
| 10 | J Colloid Interf Sci 显示文摘 | Foster T Dorfman K D Davis H T | 2010 | 351(1):140-1502010，351，1： | 1 |
| 11 | Effect of Salmonella typhimurium ferric uptake regulator (Fur) mutations on iron- and pH-regu lated protein synthesis显示文摘 | FOSTER J W HALL K H | 1992 | Journal of Bacteriology1992，174，13： | 1 |
| 12 | Mathematical Representation of Solute Solubility in Supercritical Carbon Dioxide Using Empirical Expressions显示文摘 | JOUYBAN A CHAN H K FOSTER N R | 2002 | Journal of Supercritical Fluids2002，24，： | 1 |
| 13 | Interleukin-29uses a type1interferon-like program to promote antiviral responses in human hepatocytes显示文摘 | Doyle SE Schreckhise H Khuu-Duong K Henderson K Rosler R Storey H Yao L Liu H Barahmand-pour F Sivakumar P Chan C Birks C Foster D Clegg CH Wietzke-Braun P Mihm S Klucher KM | 2006 | Hepatology2006，44，4： | 1 |
| 14 | Effect of surface cooling and blood flow on the microwave heating of tissue显示文摘 | Foster K R Kritikos H N Schwan H P | 1978 | IEEE Trans on Biomed Eng1978，25，3： | 1 |
| 15 | Electric properties of tissues and biological materials:a critical view显示文摘 | SCHWAN H | 1989 | Crit Rev Biomed Eng1989，17，1： | 1 |
| 16 | Integrins and proximal signaling mechanisms in cardiovascular disease 显示文摘 | LAL H VERMA S K FOSTER D M | 2009 | Front Bioscience2009，14，： | 1 |
| 17 | The rapid destabilization of p53 mRNA in immortal chicken embryo fibroblast cells显示文摘 | KIM H YOU S FOSTER L K | 2001 | Oncogene2001，20，37： | 1 |
| 18 | Development and E-valuation of a Cloud-gap-filled MODIS Daily Snow-coverProduct显示文摘 | Hall D K Riggs G A Foster J h | 2010 | Remote Sensing of Environment2010，114，： | 1 |
| 19 | Gene therapy progress and prospects: Duchenne muscular dystrophy显示文摘 | Foster K Foster H Dickson JG | 2006 | Gene Ther2006，13，24： | 1 |
| 20 | Attenuation of edema and infarct volume following focal cerebral ischemia by early but not delayed administration of a novel small molecule KDR kinase inhibitor显示文摘 | Foster K A Regan H K Danziger A P | 2009 | Neurosci Res2009，63，1： | 1 |
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