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| 1 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 2 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 3 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 4 | Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study显示文摘 | Sheila A Bingham Nicholas E Day Robert Luben Pietro Ferrari Nadia Slimani Teresa Norat Fran?oise Clavel-Chapelon Emmanuelle Kesse Alexandra Nieters Heiner Boeing Anne Tj?nneland Kim Overvad Carmen Martinez Miren Dorronsoro Carlos A Gonzalez Timothy J Key | 2003 | The Lancet2003，，9368： | 1 |
| 5 | Establishment and eharacterisation nf a new tumorigenic cell line with a normal karyotype derived from a human breasl adenocarcinoma显示文摘 | Gioanni J Ire Fran~ ois D Zanghellini E | 1990 | Br J Cancer1990，62，1： | 1 |
| 6 | Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers:a double-blind,randomised,placebo-controlled,cross-over trial显示文摘 | FRAN(C)OIS I E LESCROAT O VERAVERBEKE W S | 2012 | British Joumal of Nutrition2012，108，12： | 1 |
| 7 | Aluminium co mposite coatings containing micrometre and nanometre-sized particles eleetroplated from a non-aqueous electrolyte 显示文摘 | Fran saer J Leunis E | 2002 | Applied Electrochemistry2002，32，2： | 1 |
| 8 | A cooperative approach to particle swarm optimization显示文摘 | Frans V D B Andries P E | 2004 | IEEE Transactions on Evolutionary Computation2004，8，22： | 1 |
| 9 | Transesophageal two - dimensional echocardiographic identification of hiatal hernia显示文摘 | FRANS E E NANDA N C PATELI V | 2005 | Echocardiography2005，22，6： | 1 |
| 10 | A new low-cost sensorless MPPT algorithmor small wind turbines显示文摘 | René Aubrée Fran(c)ois Auger Ping Dai | | 0，，： | 1 |
| 11 | Duodenogastroesophageal reflux and oesophageal mucosal injury in mechanically ventilated patients 显示文摘 | Wilmer A Tack J Frans E | 1999 | Gastroenterology1999，116，6： | 1 |
| 12 | Twin pregnancy with complete hydatidiform mole and coexistent fetus显示文摘 | Jér?me Massardier Fran?ois Golfier Dorothée Journet Lucien Frappart Marcel Zalaquett Anne Marie Schott Véronique Trillet Lenoir Olivier Dupuis Touria Hajri Daniel Raudrant | 2009 | European Journal of Obstetrics and Gynecology2009，，2： | 1 |
| 13 | J of Biol Inorg Chem显示文摘 | van G Adriaan J Frans B H Cornelis E | 2004 | 9(1) :109-1172004，9，1： | 1 |
| 14 | Interactions of DPXPE350 with fluazifop-P, sethoxydim, clethodim, and quizalofop-P 显示文摘 | ordan D L Frans R E McClelland M R | 1993 | Weed Technol1993，7，： | 1 |
| 15 | Clinical events in high-risk hypertensive patients randomly assigned to calcium channd blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trial显示文摘 | Frans HH Leenen Chuke E | 2006 | Hypertension2006，48，： | 1 |
| 16 | Soil - carpophore in some Italian turffl epedo - environments 显示文摘 | Zanini E Giovannet T G Fran C N | 1995 | Agricoltura Med Iterranea1995，125，： | 1 |
| 17 | Lichenic extracts and metabolites as UV filters显示文摘 | Fran oise Lob e zic-Le D e v e hat B e atrice Legouin C e line Couteau | 2013 | Journal of Photochemistry and Photobiology B: Biology2013，120，： | 1 |
| 18 | Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response显示文摘 | Jacquelin Béatrice Mayau Véronique Targat Brice Liovat Anne-Sophie Kunkel Désirée Petitjean Ga?l Dillies Marie-Agnès Roques Pierre Butor Cécile Silvestri Guido Giavedoni Luis D Lebon Pierre Barré-Sinoussi Fran?oise Benecke Arndt Müller-Trutw | 2009 | Journal of Clinical Investigation2009，，： | 1 |
| 19 | A phase II trial of raltitrexed(Tomudex)in advanced pancreatic and biliary carcinoma显示文摘 | Franois E Hebbar M Bennouna J | | 0，，： | 1 |
| 20 | Immune response to Helicobacter pylori infection and gastric cancer development显示文摘Gastric adenocarcinoma is a global health concern,and Helicobacter pylori(H.pylori)infection is the main risk factor for its occurrence.Of note,the immune response against the pathogen seems to be a determining factor for gastric oncogenesis,and increasing evidence have emphasized several host and bacterium factors that probably influence in this setting.The development of an inflammatory process against H.pylori involves a wide range of mechanisms such as the activation of pattern recognition receptors and intracellular pathways resulting in the production of proinflammatory cytokines by gastric epithelial cells.This process culminates in the establishment of distinct immune response profiles that result from the cytokine-induced differentiation of T naïve cells into specific T helper cells.Cytokines released from each type of T helper cell orchestrate the immune system and interfere in the development of gastric cancer in idiosyncratic ways.Moreover,variants in genes such as single nucleotide polymorphisms have been associated with variable predispositions for the occurrence of gastric malignancy because they influence both the intensity of gene expression and the affinity of the resultant molecule with its receptor.In addition,various repercussions related to some H.pylori virulence factors seem to substantially influence the host immune response against the infection,and many of them have been associated with gastric tumorigenesis. | Breno Bittencourt de Brito Fabian Fellipe Bueno Lemos Caroline da Mota Carneiro Andressa Santos Viana Nilo Manoel Pereira Vieira Barreto Gabriela Alves de Souza Assis Barbara Dicarlo Costa Braga Maria Luísa Cordeiro Santos Filipe Antônio França da Silva Hanna Santos Marques Natália Oliveira e Silva Fabrício Freire de Melo | 2021 | World Journal of Meta-Analysis2021，9，3： | 1 |
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