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| 1 | Gut microbiota-related complications in cirrhosis显示文摘Gut microbiota plays an important role in cirrhosis. The liver is constantly challenged with commensal bacteria and their products arriving through the portal vein in the so-called gut-liver axis. Bacterial translocation from the intestinal lumen through the intestinal wall and to mesenteric lymph nodes is facilitated by intestinal bacterial overgrowth, impairment in the permeability of the intestinal mucosal barrier, and deficiencies in local host immune defences. Deranged clearance of endogenous bacteria from portal and systemic circulation turns the gut into the major source of bacterialrelated complications. Liver function may therefore be affected by alterations in the composition of the intestinal microbiota and a role for commensal flora has been evidenced in the pathogenesis of several complications arising in end-stage liver disease such as hepatic encephalopathy, splanchnic arterial vasodilatation and spontaneous bacterial peritonitis. The use of antibioticsis the main therapeutic pipeline in the management of these bacteria-related complications.However,other strategies aimed at preserving intestinal homeostasis through the use of pre-,pro-or symbiotic formulations are being studied in the last years.In this review,the role of intestinal microbiota in the development of the most frequent complications arising in cirrhosis and the different clinical and experimental studies conducted to prevent or improve these complications by modifying the gut microbiota composition are summarized. | Isabel Gómez-Hurtado José Such Yolanda Sanz Rubén Francés | 2014 | World Journal of Gastroenterology2014，20，42： | 12 |
| 2 | 国际胃袖状切除专家共识:基于>12000手术病例的最佳操作指南显示文摘腹腔镜胃袖状切除术(1aparoscopic sleeve gastrectomy,LSG)系相对较新的减重手术方式。因其操作相对简单、治疗肥胖合并疾病及减重效果明显,逐步得以广泛接受。目前美国代谢与减重手术协会将其推荐为肥胖症治疗的单独标准术式。2011年3月25~26日, | 苏远涛 徐安安 朱江帆 Diaz AA Arvidsson D Baker RS Basso N Bellanger D Boza C El Mourad H France M Gagner M Galvao-Neto M Higa KD Himpens J Hutchinson CM Jacobs M Jorgensen JO Jossart G Lakdawala M Nguyen NT Nocca D Prager G Pomp A Ramos AC Rosenthal RJ Shah S Vix M Wittgrove A Zundel N | 2013 | 中国微创外科杂志2013，13，9： | 12 |
| 3 | GPS(全球定位系统)同步电流差动保护的应用显示文摘介绍数字式电流差动保护在输配电网络中作为主保护的应用情况。讨论电力部门为降低成本而租用电信通道时遇到的问题,分析说明GPS同步数字式电流差动保护如何通过同步数字级(SDH或SONET环)电信网而实现保护的高可靠性。 | S H Richards, S Potts, N Robinson, S Pickering, A Apostolov(Alstom T&D Protection & Control, France) | 2002 | 国际电力2002，6，3： | 8 |
| 4 | Pathological bacterial translocation in cirrhosis: pathophysiology, diagnosis and clinical implications显示文摘 | Pablo Bellot Rubén Francés Jose Such | 2012 | Liver Int2012，，1： | 4 |
| 5 | Immunomodulating effects of antibiotics used in the prophylaxis of bacterial infections in advanced cirrhosis显示文摘The use of norfloxacin either as primary or secondary prophylaxis of bacterial infections in advanced cirrhosis has improved patient's survival. This may be explained not only due to a significant decrease in the number of infections, but also because of a direct immunomodulatory effect. Selective intestinal decontamination with norfloxacin reduces translocation of either viable bacteria or bacteria-driven products from the intestinal lumen. In addition, norfloxacin directly modulates the systemic inflammatory response. The proinflammatory cytokine profile secreted by neutrophils from these patients shows a close, significant, and inverse correlation with serum norfloxacin levels. Similar effects have been described with other quinolones in different clinical conditions. Although the underlying mechanisms are not well defined for most of the antibiotics, the pathways triggered for norfloxacin to induce such immunomodulatory effects involve the down-regulation of pro-inflammatory inducible nitric oxide synthase, cyclooxygenase-2, and NF-κB and the up-regulation of heme-oxygenase 1 and IL-10 expression. The knowledge of these immunomodulatory effects, additional to their bactericidal role, improves our comprehension of the interaction between antibiotics and the cellular host response and offer new possibilities for the development of new therapeutic strategies to manage and prevent bacterial infections in cirrhosis. | Pedro Zapater José Manuel González-Navajas José Such Rubén Francés | 2015 | World Journal of Gastroenterology2015，21，41： | 3 |
| 6 | Oral probiotic VSL #3 attenuates the circulatory disturbances of patients with cirrhosis and ascites显示文摘 | Diego Rincón Javier Vaquero Ana Hernando Evelyn Galindo Cristina Ripoll Marta Puerto Magdalena Salcedo Rubén Francés Ana Matilla María V. Catalina Gerardo Clemente José Such Rafael Ba?ares | 2014 | Liver Int2014，，10： | 2 |
| 7 | Bacterial DNA Induces the Complement System Activation in Serum and Ascitic Fluid from Patients with Advanced Cirrhosis显示文摘 | Rubén Francés José M. González-Navajas Pedro Zapater Carlos Mu?oz Rocío Ca?o Sonia Pascual Dorkas Márquez Francia Santana Miguel Pérez-Mateo José Such | 2007 | Journal of Clinical Immunology2007，，4： | 2 |
| 8 | Protective effect of Bifidobacterium pseudocatenulatum CECT 7765 against induced bacterial antigen translocation in experimental cirrhosis显示文摘 | Alba Moratalla Isabel Gómez‐Hurtado Arlette Santacruz ángela Moya Gloria Peiró Pedro Zapater José M. González‐Navajas Paula Giménez José Such Yolanda Sanz Rubén Francés | 2014 | Liver Int2014，，6： | 2 |
| 9 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 10 | Evidence of neutrophil functional defect despite inflammation in stable cirrhosis显示文摘 | Giovanni Tritto Zois Bechlis Vanessa Stadlbauer Nathan Davies Rubén Francés Naina Shah Rajeshwar P. Mookerjee Jose Such Rajiv Jalan | 2011 | Journal of Hepatology2011，，3： | 2 |
| 11 | Activation of human endothelial cells via S-endo-1 antigen(CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK)显示文摘 | Anfosso F Bardin N Frances V | 1998 | J Biol Chem1998，273，26： | 1 |
| 12 | Directory of clinical nurse specialist programs in the United States显示文摘 | Spross JA Gerard PS France N | 2006 | Clin Nurse Spec2006，20，1： | 1 |
| 13 | Identification of the S-Endo 1 endothelial-associated antigen显示文摘 | Bardin N Frances V Lesaule G | 1996 | Biochem Biophys Res Commun1996，218，1： | 1 |
| 14 | Activation of human endothelial cells via S-endo-1 antigen ( CD146 ) stimulates the tyrosine- phosphorylation of focal adhesion kinase p125 (FAK) 显示文摘 | Anfosso F Bardin N Frances V | 1998 | J Biol Chem1998，273，26： | 1 |
| 15 | Does educational attainment contribute to risk for delirium? A potential role for cognitive reserve显示文摘 | Richard N Jones Frances M Yang Zhang Ying | 2006 | J Gerontol A Biol Sci Med Sci2006，61，12： | 1 |
| 16 | An investigation of head-sea parametric rolling and its influence on container lashing systems 显示文摘 | FRANCE W N LEVADOU M TREAKLE T W | 2003 | Marine technology2003，40，1： | 1 |
| 17 | Treatment of depression in type 2 diabetic patients:effects on depressive symptoms, quality of life and metabolic control 显示文摘 | N icolau J Rivera R Frances C | 2013 | Diabetes Res Clin Pract2013，101，2： | 1 |
| 18 | Small circular- and rectangular-channel boiling with two refrigerants 显示文摘 | TRAN T N WAMBSGANSS M W FRANCE D M | 1996 | International Journal of Multiphase Flow1996，22，3： | 1 |
| 19 | Changes of surface and volume properties of calcite during a batch wet grinding process显示文摘 | Garcia F Le Bolay N Frances C | | 0，，2： | 1 |
| 20 | An investigation of head-sea parametric rolling and its influence on container lashing systems显示文摘 | FRANCE W N LEVADOU M TREAKLE T W | 2003 | Marine Technology2003，40，1： | 1 |
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