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6篇 您的检索式：作者名="Francesc Villarroya"

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		题名	作者	年代	出处	被引量
	1	SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases.	Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera	2020	Signal Transduction and Targeted Therapy2020，5，1：	7
	2	White, Brown, Beige/Brite: Different Adipose Cells for Different Functions?显示文摘	Marta Giralt Francesc Villarroya	2013	Endocrinology2013，，9：	1
	3	Beyond the Sympathetic Tone: The New Brown Fat Activators显示文摘	Francesc Villarroya Antonio Vidal-Puig	2013	Cell Metabolism2013，，5：	1
	4	BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions显示文摘	Andrew J. Whittle Stefania Carobbio Luís Martins Marc Slawik Elayne Hondares María Jesús Vázquez Donald Morgan Robert I. Csikasz Rosalía Gallego Sergio Rodriguez-Cuenca Martin Dale Samuel Virtue Francesc Villarroya Barbara Cannon Kamal Rahmouni Miguel Lóp	2012	Cell2012，，4：	1
	5	GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK显示文摘	Beiroa Daniel Imbernon Monica Gallego Rosalía Senra Ana Herranz Daniel Villarroya Francesc Serrano Manuel Fern? Johan Salvador Javier Escalada Javier Dieguez Carlos Lopez Miguel Frühbeck Gema Nogueiras Ruben	2014	Diabetes2014，，10：	1
	6	Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat显示文摘	Elayne Hondares Meritxell Rosell Frank J. Gonzalez Marta Giralt Roser Iglesias Francesc Villarroya	2010	Cell Metabolism2010，，3：	1

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