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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Effect of femtosecond laser-assisted lens surgery on the optic nerve head and the macula显示文摘AIM: To evaluate the effect of femtosecond laser-assisted lens surgery(FLALS;cataract surgery or refractive lens exchange) on the structure of the optic nerve head and the macula.METHODS: This prospective longitudinal study included healthy eyes undergoing FLALS. Eyes with glaucoma or any other ocular disease that could alter optical coherence tomography results were excluded. Retinal nerve fiber layer(RNFL), Bruch’s membrane opening-minimum rim width(BMO-MRW) and macular thickness(MT) were measured preoperatively, 1 and 6 mo after surgery using spectral-domain optical coherence tomography(SD-OCT). Changes between preoperative and postoperative values were evaluated.RESULTS: A total of 87 eyes of 46 patients were included in this study. Preoperative RNFL, BMO-MRW and MT in microns(μm) were 100.77±10.39, 330.31±49.99 and 276.30±33.39, respectively. Postoperative RNFL, BMO-MRW and MT were 104.74±11.55, 348.32±54.05 and 279.83±22.65 1 mo after surgery and 102.93±11.17, 343.11±53.4 and 278.90±22.19 6 mo after surgery, respectively;which equals an increase of 3.93%, 5.45% and 1.27%,respectively, 1 mo after surgery, and 2.14%, 3.87% and 0.94% 6 mo after surgery. The differences between the preoperative and the postoperative RNFL and BMO-MRW values were statistically significant(P<0.001). Regarding MT values, there were not statistically significant differences(P=0.26).CONCLUSION: Our study suggests that FLALS does not have a negative impact on the structural status of the optic nerve head in healthy eyes, assessed by SD-OCT. There is a slight increase in the values of RNFL, BMO-MRW and MT 1 mo and 6 mo after surgery. | Josefina Renones de Abajo Beatriz Estévez Jorge Jesús María González Martín Humberto Carreras Díaz Juan Francisco Loro Ferrer Alfonso Antón López | 2019 | International Journal of Ophthalmology(English edition)2019，12，6： | 2 |
| 3 | Analyses of genetic diversity in Cuban rice varieties using isozyme, RAPD and AFLP markers显示文摘 | Jorge Luis Fuentes Fabio Escobar Alba Alvarez Geraldo Gallego Miriam Cristina Duque Mirle Ferrer Juan Enrrique Deus Joe M. Tohme | 1999 | Euphytica1999，，2： | 1 |
| 4 | Achieving Europe's R&D Objectives显示文摘 | Jorge Ntlfiez Ferrer Filipa Figueira | 2011 | Swedish Institute for European Policy Studies2011，，6： | 1 |
| 5 | Steroid-induced interface fluid syndrome after LASIK显示文摘 | Moya Calleja T Iribarne Ferrer Y Sanz Jorge A | 2009 | J Refract Surg2009，25，： | 1 |
| 6 | Achieving Europej s R&D Objectives 显示文摘 | Jorge Nfi?ez Ferrer Filipa Figueira | 2011 | Swedish Institute for European Policy Studies2011，，6： | 1 |
| 7 | Steroid-induced interface fluid syndrome after LASIK显示文摘 | Moya Calleja T Iribarne Ferrer Y Sanz Jorge A | 2009 | J Refract Surg2009，25，： | 1 |
| 8 | Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth显示文摘 | Myriam Solar Carina Cardalda Isabelle Houbracken Mercè Martín Miguel Angel Maestro Nele De Medts Xiaobo Xu Vanessa Grau Harry Heimberg Luc Bouwens Jorge Ferrer | 2009 | Developmental Cell2009，，6： | 1 |
| 9 | Steroid-induced interface fluid syndrome after LASIK显示文摘 | Moya Calleja T Iribame Ferrer Y Sanz Jorge A Sedo FernandezS | 2009 | JRefract Surg2009，25，2： | 1 |
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