|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Screw dislocation structure and mobility in body centered cubic Fe predicted by a Gaussian Approximation Potential显示文摘The plastic flow behavior of bcc transition metals up to moderate temperatures is dominated by the thermally activated glide of screw dislocations,which in turn is determined by the atomic-scale screw dislocation core structure and the associated kink-pair nucleation mechanism for glide.Modeling complex plasticity phenomena requires the simulation of many atoms and interacting dislocations and defects.These sizes are beyond the scope of first-principles methods and thus require empirical interatomic potentials.Especially for the technological important case of bcc Fe,existing empirical interatomic potentials yield spurious behavior.Here,the structure and motion of the screw dislocations in Fe are studied using a new Gaussian Approximation Potential(GAP)for bcc Fe,which has been shown to reproduce the potential energy surface predicted by density-functional theory(DFT)and many associated properties.The Fe GAP predicts a compact,non-degenerate core structure,a single-hump Peierls potential,and glide on{110},consistent with DFT results.The thermally activated motion at finite temperatures occurs by the expected kink-pair nucleation and propagation mechanism.The stress-dependent enthalpy barrier for screw motion,computed using the nudgedelastic-band method,follows closely a form predicted by standard theories with a zero-stress barrier of~1 eV,close to the experimental value of 0.84 eV,and a Peierls stress of~2 GPa consistent with DFT predictions of the Peierls potential. | Francesco Maresca Daniele Dragoni Gábor Csányi Nicola Marzari William A.Curtin | 2018 | npj Computational Materials2018，，1： | 5 |
| 3 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 4 | In-vitra interac tions of itraconazole with flucytosine against clinical isolates of Cryptococcus neoformans显示文摘 | Domenico G Francesca C | 1999 | J Antimicrob Chemother1999，44，1： | 1 |
| 5 | Continuing follow-up of malignant hypertension显示文摘 | Paolo T S Marco G Francesco D C | 2002 | J Nephrol2002，15，4： | 1 |
| 6 | Methane combustion on Mg-doped LaMn03 perovskite catalysts显示文摘 | Guido S Francesco G Giancarlo B | 1999 | Applied Catalysis B1999，20，： | 1 |
| 7 | Genomic and transcriptomic analysis of the AP2/ERF superfamily in Vitis vinifera显示文摘 | FRANCESCO L FEDERICO G SARA Z | 2010 | BMC Genomics2010，11，： | 1 |
| 8 | Lethal and estrogenic effects of 4-nonylphenol in the cockle Cerastoderma glaucum显示文摘 | Marla G M Stefano R Francesco R | 2008 | Marine Pollution Bulletin2008，57，： | 1 |
| 9 | Standardization of terminology,definitions and outcome criteria in immune thrombocypenic purpura of adults and children:report from an internationl working group 显示文摘 | FRANCESCO R ROBERTO S TREEY G | 2009 | Blood2009，113，： | 1 |
| 10 | Evaluation of vascular patterns of cervical lymph nodes with power Doppler sonography显示文摘 | Francesco G Rossela C Alssandra A | 1997 | J Clin Ultrasound1997，25，： | 1 |
| 11 | Multi-echelon, multi-in- denture spare parts inventory control subject to system availabili- ty and budget constraints显示文摘 | Francesco C Giulio D G Massimo T | 2013 | Reliability Engineering & System Safety2013，119，11： | 1 |
| 12 | Challenges and successes in developing new therapies for hepatitis C 显示文摘 | DE FRANCESCO R MIGLIACCIO G | 2005 | Nature2005，436，7053： | 1 |
| 13 | Immature germ cell separation using a modified discontinuous Percoll gradient technique in human semen显示文摘 | Loredana G Andrea L Francesco L | 1999 | Hu- man Reproduction1999，14，4： | 1 |
| 14 | pH-Sensitive hydrogels based on bovine serum albumin for oral drug delivery显示文摘 | Iemma F Spizzirri U G Francesco Puoci | 2006 | International Journal of Pharmaceutics2006，2，12： | 1 |
| 15 | Impact of 3rd gen eration drugs on the activity of first-line chemotherapy in ad ranted non small cell lung cancer (NSCLC): a meta analyti cal approach: BE 07显示文摘 | Francesco G Carlotta D Orazio V | 2007 | J Thorac Oncol2007，2，8： | 1 |
| 16 | TOPS AR:terrain observation by progressive scan 显示文摘 | D Z Francesco M G Andrea | 2006 | IEEE Trans Geoscience and Remote Sensing2006，44，9： | 1 |
| 17 | Autologous conditioned serum for the treatment of osteoarthritis and other possible applications in musculoskeletal disorders显示文摘 | Antonio F Erika G Francesco O | 2013 | British Medical Bulletin2013，105，1： | 1 |
| 18 | Technology and the issue of cost/benefit in diabetes 显示文摘 | Cosimo G Angelika M Francesco C | 2009 | Diabetes Metab Res Rev2009，25，1： | 1 |
| 19 | Influence of pH on Lysozyme Conformation Revealed by Dielectric Spectroscopy显示文摘 | Bonincontro A Francesco A D Onori G | | 0，，： | 1 |
| 20 | Nitrate removal in drinking waters: the effect of tin oxides in the catalytic hydrogenation of nitrate by Pd/SnO2 catalysts 显示文摘 | Roberta G Luca B Francesco P | 2002 | Applied Catalysis B: Environmental2002，38，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员