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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Can testosterone therapy be offered to men on active surveillance for prostate cancer? Preliminary results显示文摘这份报告在活跃监视上在 T 缺乏的人的一个队与 T 治疗介绍我们的经验(作为) 为 Gleason 3 + 3 并且 Gleason 3 + 4 前列腺癌症(PCa ) 。回顾的图表评论与 T 缺乏识别了 28 个人经历 T 治疗(T 组) 至少 6 个月了当时在上至于 PCa。96 个人在上的一个比较组至于有未经治疗的 T 缺乏的 PCa (别组织) 在一样的机构被识别。同样协议跟随了修改爱泼斯坦标准和有小量的 Gleason 3 + 的一个单个核心的人的允许的包括 4 PCa。吝啬的年龄是 59.5 和 61.3 年,并且意味着后续是为 T 的 38.9 和 42.4 个月并且不分别地组织。在 T 组的所有 28 个人, 3 (10.7%) 人们在格利森分数开发了增加当时在上作为。22,在 T 的人与 Gleason 3 + 组织 3 疾病, 7 (31.8%) 人们包括开发了 Gleason 3 + 的 3 个人(13.6%) 开发了活体检视前进 4 PCa。有 Gleason 3 + 的 6 个人在基线的 4 疾病, 2 (33.3%) 人们在肿瘤体积开发了增加,并且任何一个都没发展在 Gleason 3 + 以外升级 4。所有 96 个人在别组织有的 Gleason 3 + 在基线的 3 疾病并且,(44.7%) 43 开发了活体检视前进,包括有升级到 Gleason 7 的 9 个人(9.38%)(3 + 4 ) 。活体检视前进率为组和历史的控制是类似的。在人在上的活体检视前进作为在 3 年由 T 治疗显得未受影响。在 T 缺乏的人在上的 T 治疗的未来的控制安慰剂的试用作为应该被认为给对待的人经验丰富的征兆的好处。 | Ravi Kacker Mariam Hult Ignacio F San Francisco William P Conners Pablo A Rojas William C Dewolf Abraham Morgentaler | 2016 | Asian Journal of Andrology2016，18，1： | 2 |
| 3 | Production of free fatty acids from waste oil by application of ultrasound 显示文摘 | Larissa P L Francisco F S Enio C | 2012 | Biomass Conversion and Biorefinery2012，，2： | 1 |
| 4 | Temporal (1958-1995) pattern of ckmnge in a cultural landscape of northwestern Portugal:implications for fire occurrence显示文摘 | FRANCISCO M REGOL F C PAULO G | 2001 | Landscape Ecology2001，16，： | 1 |
| 5 | Muscle fiber type characterization and myosin heavy chain (MyHC) isoform expression in Mediterranean buffaloes显示文摘 | Francisco C L Jorge A M Carani F R | 2011 | Meat Science2011，88，3： | 1 |
| 6 | Development and validation of an HPLC - DAD method for analysis of the six major isofla- vones in extracts from soybean processing 显示文摘 | Gasparetto J C Smolarek F S F De Francisco | 2012 | J Am Oil Chem Soc2012，89，7： | 1 |
| 7 | Temporal (1958-1995) pattern of ckmnge in a cultural landscape of northwestern Portugal:implications for fire occurrence显示文摘 | FRANCISCO M REGOL F C PAULO G | 2001 | Landscape Ecology2001，16，： | 1 |
| 8 | Rate coefficient for reaction SiO+Si2O2 at T=10-1 000 K显示文摘 | André S P Francisco C A Alberico B F | 2006 | J Phys Chem A2006，110，13： | 1 |
| 9 | A new search algorithm for QSPR/QSAR theories:normal boiling points of some organic molecules显示文摘 | Pablo R D Eduardo A C Francisco M F | 2005 | Chemical Physics Letters2005，412，： | 1 |
| 10 | Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF 显示文摘 | Quigley M Pereyra F Nilsson B Porichis F Fonseca C Eichbaum Q Julg B Jcsneck JL Brosnahan K Imam S Russell K Toth I Piechocka-Trocha A Dolfi D Ange- losanto J Crawford A Shin H Kwon DS Zupkosky J Francisco L Freeman GJ Wherry Kaufmann DE Walker BD Ebert B Haining WN | 2010 | Nat Med2010，16，10： | 1 |
| 11 | SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase(ALK) receptors ALK4,ALK5, and ALKT显示文摘 | GARETH J I FRANCISCO J N JAMES F C | 2002 | Mol Pharmaco12002，62，1： | 1 |
| 12 | Determination of volatile phenols in red wines by dispersive liquid-liquid microextraction and gas chromatography-mass spectrometry detection显示文摘 | Laura F Eduardo B Francisco C | 2007 | J Chromatogr A2007，1157，： | 1 |
| 13 | The structure and resilience of financial market networks显示文摘 | Thomas K D P Luciano F C Francisco A R | 2012 | Chaos2012，22，1： | 1 |
| 14 | The structure and resilience of financial market networks 显示文摘 | Thomas K D P Luciano F C Francisco A R | 2012 | Chaos2012，22，01： | 1 |
| 15 | Early Hormonal Markers of Pregnancy Outcome After In Vitro Fertilization and Embryo Transfer显示文摘 | Francisco Carmona Juan Balasch Montserrat Creus Francisco Fábregues Roser Casamitjana Salvadora Cívico Ester Vidal Josep M. Calafell Vicenta Moreno Juan A. Vanrell | 2003 | Journal of Assisted Reproduction and Genetics2003，，12： | 1 |
| 16 | Early Hormonal Markers of Pregnancy Outcome After In Vitro Fertilization and Embryo Transfer显示文摘 | Francisco Carmona Juan Balasch Montserrat Creus Francisco Fábregues Roser Casamitjana Salvadora Cívico Ester Vidal Josep M. Calafell Vicenta Moreno Juan A. Vanrell | 2003 | Journal of Assisted Reproduction and Genetics2003，，12： | 1 |
| 17 | Effect of the application of silicon hydroxide on yield and quality of cher- ry tomato 显示文摘 | Fernando T S Antonio V G Francisco C F | 2012 | Journal of Plant Nutrition2012，35，4： | 1 |
| 18 | Temporal (1958 -1995) Pattern of Change in a Cultural Landscape of Northwestern Portugal:Implications for Fire Occurrence 显示文摘 | Francisco M Regol F C Paulo G | 2001 | Landscape Ecology2001，16，： | 1 |
| 19 | Esophagogastric junction outflow obstruction successfully treated with laparoscopic Heller myotomy and Dor fundoplication: First case report in the literature显示文摘BACKGROUND Esophagogastric junction outflow obstruction(EGJOO) is a rare syndrome,characterized by an elevation of the integrated relaxation pressure of the lower esophageal sphincter, not accompanied by alterations in esophageal motility that may lead to the criteria for achalasia. We were unable to find any prior report of the combination of Heller myotomy with anterior partial fundoplication(Dor) as the treatment for EGJOO. We herein report a case of EGJOO treated with laparoscopic Heller myotomy combined with Dor fundoplication.CASE SUMMARY A 26-year-old man presented with a 3-year history of solid dysphagia and a 30-kg weight loss. He was treated with oral nifedipine, isosorbide, and omeprazole,without resolution of symptoms. An upper gastrointestinal series(barium swallow) revealed a 'bird's beak' sign. Esophagogastroduodenoscopy was positive for Los Angeles grade A peptic esophagitis. High-resolution esophageal manometry was compatible with EGJOO. Esophageal pH monitoring showed pathological acid reflux both in orthostatic and decubitus position. An 8-cm laparoscopic Heller myotomy combined with an anterior 220° Dor fundoplication was performed. Solid diet was introduced on postoperative day 2, and the patient was discharged home the same day. At 17-mo follow-up, he reported no symptoms. Barium swallow was compatible with complete radiologic resolution.Both esophageal manometry and upper endoscopy showed normal findings 9 mo after the operation.CONCLUSION Surgical treatment with Heller myotomy and Dor fundoplication is a potential treatment option for EGJOO refractory to medical treatment. | Pedro F Pereira Andre RP Rosa Leonardo A Mesquita Marcelle J Anzolch Rafael N Branchi Augusto L Giongo Francisco C Paix?o Marcio F Chedid Cleber DP Kruel | 2019 | World Journal of Gastrointestinal Surgery2019，11，2： | 1 |
| 20 | Straightforward rapid spectrophotometric quantification of total cyanogenic glycosides in fresh and processed cassava products显示文摘 | TIVANA L D FRANCISCO J D C ZELDEK F | 2014 | Food Chemistry2014，158，1： | 1 |
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