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| 1 | Efficacy and safety of endoscopic prophylactic treatment with undiluted cyanoacrylate for gastric varices显示文摘AIM:To evaluate the efficacy and safety of undiluted N-butyl-2 cyanoacrylate plus methacryloxysulfolane(NBCM)as a prophylactic treatment for gastric varices(GV)bleeding.METHODS:This prospective study was conducted at a single tertiary-care teaching hospital between October 2009 and March 2013.Patients with portal hypertension(PH)and GV,with no active gastrointestinal bleeding,were enrolled in primary prophylactic treatment with NBCM injection without lipiodol dilution.Initial diagnosis of GV was based on endoscopy and confirmed with endosonography(EUS); the same procedure was used after treatment to confirm eradication of GV.After puncturing the GV with a regular injection needle,1 mL of undiluted NBCM was injected intranasally into GV.The injection was repeated as necessary to achieve eradication or until a maximum total volume of 3 mL of NBCM had been injected.Patients were followed clinically and evaluated with endoscopy at 3,6 and 12 mo.Later follow-ups were performed yearly.The main outcome measures were efficacy(GV eradication),safety(adverse events related to cyanoacrylate injection),recurrence,bleeding from GV and mortality related to GV treatment.RESULTS:A total of 20 patients(15 male)with PH and GV were enrolled in the study and treated with undiluted NBCM injection.Only 2(10%)patients had no esophageal varices(EV); 18(90%)patients were treated with endoscopic band ligation to eradicate EV before inclusion in the study.The patients were followed clinically and endoscopically for a median of 31 mo(range:6-40 mo).Eradication of GV was observed in all patients(13 patients were treated with 1 session and 7 patients with 2 sessions),with a maximum injected volume of 2 mL NBCM.One patient had GV recurrence,confirmed by EUS,at 6-mo follow-up,and another had late recurrence with GV bleeding after 35 mo of follow-up; overall,GV recurrence was observed in 2 patients(10%),after 6 and 35 mo of follow-up,and GV bleeding rate was 5%(1 patient).Mild epigastric pain was reported by 3 patients(15%).No mortality or major complications,including embolism,or damage to equipment were observed.CONCLUSION:Endoscopic injection with NBCM,without lipiodol,may be a safe and effective treatment for primary prophylaxis of gastric variceal bleeding. | Matheus Cavalcante Franco Gustavo Flores Gomes Frank Shigeo Nakao Gustavo Andrade de Paulo Angelo Paulo Ferrari Jr Ermelindo Della Libera Jr | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，6： | 16 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Cryptococcal me ningoencephalitis and pulmonary noduleinnon-HIV-infecte- dimmunoeompetentpatient 显示文摘 | Lambertucci JR Franco R de Queiroz LC | 2005 | Rev Soc Bras Med Trop2005，38，2： | 1 |
| 4 | Xenon purity analysis for exo-200 via mass spectrometry 显示文摘 | Dobi A Hall C Slutsky S Yen Y R Aharmin B Auger M Barbeau P S Benitez-Medina C Breidenbach M Cleveland B Conley R Cook J Cook S Counts I Craddock W Daniels T Davis C G Davis J Devoe R Dixit M Dolinski M J Donato K Fairbank Jr W Farine J Fierlinger P Franco D Giroux G Gornea R Graham K Gratta G Green C Hagemann C Hall K Hallman D Hargrove C Herrin S Hughes M Hodgson J Juget F Karelin A Kaufman L J Kuchenkov A Kumar K Leonard D S Lutter G Mackay D Maclellan R Marino M Mong B Montero Diez M Morgan P MUller A R Neilson R Odian A Oullivan K Piepke A Pocar A Prescott C Y Pushkin K Rivas A Rollin E Rowson P C Sabourov A Sinclair D Skarpaas K Stekhanov V Strickland V Swift M Twelker K Vuilleumier J L Vuilleumier J M Weber M Wichoski U Wodin J Wright J D Yang L | 2012 | Nuclear Instruments and Methods in Physics Research Section A: Accelerators Spectrometers Detectors and Associated Equipment2012，675，： | 1 |
| 5 | Re- dundant or separate entities roles of Twistl and Twist2 as molecular switches during gene trans-cription 显示文摘 | Franco HL Casasnovas J Rodrfguez-Medina JR | 2011 | Nucleic Acids Res2011，39，4： | 1 |
| 6 | Quality of life for children with obstructive sleep apnea显示文摘 | Franco JR Richard M Rao M | 1999 | Otolaryngology-Head and Neck Surgery1999，121，2： | 1 |
| 7 | Quality of life for children withobstructive sleep apnea显示文摘 | Franco RA Jr Rosenfeld RM Rao M | 2000 | Otolaryngol Head Neck Surg2000，123，11： | 1 |
| 8 | First place- resident clinical science award 1999: Quality of life for children with obstructive sleep apnea显示文摘 | Franco RA Jr Rosenfeld RM Rao M | 2000 | Otolaryngol Head Neck Surg2000，123，： | 1 |
| 9 | Redundant or separate entities? roles of Twist1 and Twist2 as molecular switches during gene transcription显示文摘 | Franco HL Casasnovas J Rodriguez-Medina JR | 2011 | Nucleic Acids Res2011，39，4： | 1 |
| 10 | Effects ofrecombinant LH supplementation to recombinant FSH duringinduced ovarian stimulation in the GnRH-agonist protocol: amatched case-control study显示文摘 | Franco JG Jr Baruffi RL Oliveira JB | 2009 | Reprod Biol Endocrinol2009，7，： | 1 |
| 11 | Effects of recombinant LH supplementation to re- combinant FSH during induced ovarian stimulation in the GnRH-agonist protocol: a matched case-con- trol study显示文摘 | Franco JG Jr Baruffi RL Oliveira JB | 2009 | Reprod Biol Endocrinol2009，7，： | 1 |
| 12 | Thermal perfomlance modeling ofNASA's scientific balloons 显示文摘 | Franco H Cathey H M Jr | 2004 | Advances in Space Research2004，33，10： | 1 |
| 13 | Significance of large nuclear vacuoles in human spermatozoa:implications for ICSI 显示文摘 | Franco JG Jr Baruffi RL Mauri AL | 2008 | Reprod Biomed Online2008，17，1： | 1 |
| 14 | ProBNP for stratifying patients with heart failure 显示文摘 | Pereira - Barretto AC De Oliveira MT Jr Franco FG | 2003 | Arq Bras Cardiol2003，81，3： | 1 |
| 15 | First place-resident clinical science award 1999: Quality of life for childrenwith obstruction sleep spnea显示文摘 | Franco RA Jr Rosenfeld RM Rao M | 2000 | Otolaryngol Head Neck Surg2000，123，1： | 1 |
| 16 | HIF- lalpha diminishes SGLTl and SGLT2 expression in renal epithelial tubular cells (LLC-PK1) under hypoxia 显示文摘 | Zapata-Morales JR Galicia-Cruz OG Franco M | 2014 | J Biol Chem2014，289，1： | 1 |
| 17 | Laryngeal chondroma显示文摘 | Franco RA Jr Singh B Har-El G | 2002 | J Voice2002，16，： | 1 |
| 18 | Best site for embryo transfer: the upper or lower half of endometrial cavity?显示文摘 | Franco JG Jr Martins AM Baruffi RL | 2004 | Hum Reprod2004，19，8： | 1 |
| 19 | Laryngeal chondroma显示文摘 | FRANCO R A Jr SINGH B HAR-EL G | 2002 | J Voice2002，16，1： | 1 |
| 20 | Best site for embryo transfer:the upper or lower half of endometrial cavity显示文摘 | FRANCO J G Jr MARTINS A M BARUFFI R L | | 0，，08： | 1 |
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