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| 1 | interrelationships between ghrelin, insulin and glucose homeostasis: physiological relevance显示文摘Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach. Both acylated(AG) and unacylated(UAG) forms of ghrelin are found in the circulation. Initially, AG was considered as the only bioactive form of ghrelin. However, recent advances indicate that both AG and UAG exert distinct and common effects in organisms. Soon after its discovery, ghrelin was shown to promote appetite and adiposity in animal and human models. In response to these anabolic effects, an impressive number of elements have suggested the influence of ghrelin on the regulation of metabolic functions and the development of obesityrelated disorders. However, due to the complexity ofits biochemical nature and the physiological processes it governs, some of the effects of ghrelin are still debated in the literature. Evidence suggests that ghrelin influences glucose homeostasis through the modulation of insulin secretion and insulin receptor signaling. On the other hand, insulin was also shown to influence circulating levels of ghrelin. Here, we review the relationship between ghrelin and insulin and we describe the impact of this interaction on the modulation of glucose homeostasis. | FranCois Chabot Alexandre Caron Mathieu Laplante David H St-Pierre | 2014 | World Journal of Diabetes2014，5，3： | 9 |
| 2 | Internal sur-faces including phase change materials for passive opti-mal shift of solar heat gain 显示文摘 | Arnault A Mathieu P Francois | 2010 | Thermal Science2010，49，11： | 1 |
| 3 | Prediction of cadmium and zinc concentration in wheat grain from soils affected by the application of phosphate fertilizers varying in Cd concentration显示文摘 | Mathieu Francois Cynthia Grant Raphael Lambert Sebastian Sauve | 2009 | Nutr Cycl Agroecosyst2009，83，： | 1 |
| 4 | Aqueous hydroformylation reaction mediated by randomly methylated β - cyclodextrin : How substitution degree influences catalytic activity and selectivity 显示文摘 | Francois - Xavier Legrand Mathieu Sauthier Christophe Flahaut | 2009 | Journal of Molecular Catalysis A : Chemical2009，303，： | 1 |
| 5 | Compara- tive Evaluation of the Active Eye and Skin Chemical Splash Decontamination Solution Diphoterine and Hexafluorine with Water and other Rising Solutions: Efficts on Burn Severity and Healing 显示文摘 | Laurence Mathieu Francois Burgher Joel Blomet | 2007 | Journal of Chemical Health and Safety2007，2，1： | 1 |
| 6 | Frequency-band complex noniteger differentiator: characterization and synthesis 显示文摘 | Alain Oustaloup Francois Levron Benoit Mathieu | 2000 | IEEE Transactions on circuits and systems 1 : Fundamental theory and applications2000，47，1： | 1 |
| 7 | Human mesenchymal stem cells favour healing of the cutaneous radiation syndrome in a xenogenic transplant model显示文摘 | Francois S Mouiseddine M Mathieu N | 2007 | Ann Hematol2007，86，1： | 1 |
| 8 | Appearance-based loop closure detection for online large-scale and long-term operation显示文摘 | MATHIEU L FRANCOIS M | 2013 | IEEE Transaction on Robotics2013，9，3： | 1 |
| 9 | Comparison of the Quality of Qualitative Data Obtained Through Telephone,Postal and Email Survey显示文摘 | Anne Mathieu Natalie St-Laurent | 2004 | International Journal of Market research2004，46，3： | 1 |
| 10 | Hydrothermal synthesis of nanosized BaTiO3 powders and dielectric properties of corresponding ceramics 显示文摘 | Madona Boulos Sophie Guillernet-Fritsch Francois Mathieu | 2005 | Solid State Ionics2005，176，： | 1 |
| 11 | State-dependent properties of a new T-type calcium channel blocker enhance Ca V 3.2 selectivity and support analgesic effects显示文摘 | Amaury Francois Nicolas Kerckhove Mathieu Meleine Abdelkrim Alloui Christian Barrere Agathe Gelot Victor N. Uebele John J. Renger Alain Eschalier Denis Ardid Emmanuel Bourinet | 2012 | Pain2012，，： | 1 |
| 12 | Laser Welding of AZ91 and WFA3 Magnesium Alloys 显示文摘 | Mohamed Dhahri Jean Eric Masse Jean Francois Mathieu | 2001 | Advanced Engineering Materials2001，3，7： | 1 |
| 13 | Frequency-band complex noninteger differentiator:characterization and synthesis显示文摘 | Oustaloup Alain Levron Francois Mathieu Benoit etal | 2000 | IEEE Transactionson Circuit and Systems2000，47，1： | 1 |
| 14 | 非ST段抬高急性冠脉综合征患者噻吩并吡啶类药物预治疗的再评价:一项系统性综述和meta分析显示文摘目的探讨非sT段抬高急性冠脉综合征患者应用P2Y12受体拮抗剂预治疗与未行预治疗相比的有效性和安全性。数据来源两名研究者独立检索Medline、Embase、Cochrane Controlled Trials和BioMed Central数据库,查找2001年至2014年随机对照试验和观察性研究。入选标准研究必须报告全因病死率(主要疗效终点)和大出血事件(安全性终点)结局。数据提取独立提取和分析有关样本量、人群特征、药物剂量、服药延迟情况和临床预后信息的数据。 | Anne BeUemain-Appaix Mathieu Kerneis Stephen A O'Connor Johanne Silvain Michel Cucherat Farzin Beygui Olivier Barthelemy Jean-Philippe Collet Laurent Jacq Francois Bernasconi Gilles Montalescot 葛兴 史旭波 | 2015 | 英国医学杂志中文版2015，18，3： | 0 |
| 15 | AB035. Lactate receptor GPR81 modulates epigenetic modification in the subretina显示文摘Background:Retinal pigment epithelium(RPE)is vital for the homeostasis of the subretina including photoreceptors and choroid.Interestingly,our previous results suggested that the recently discovered lactate receptor GPR81 is abundantly expressed in RPE.To date,only one previous study has shown that activating GPR81 could enhance DNA repair by activating HDAC1.Consequently,we investigated whether GPR81 exhibits epigenetic modification in the subretina by using GPR81−/−mice.Methods:GPR81−/−mice and wide type littermates were generated on a background of C57BL/6J mice.The thicknesses of their choroid were evaluated by immunohistochemistry.Meanwhile,Q-PCR,western blot and choroid sprout assay were performed.In vitro,primary retinal pigment epithelium(pRPE)cells were isolated from mice,and cultured for treatments.Results:The thickness of choroid was reduced in GPR81−/−mice compared to GPR81+/+mice,suggesting that GPR81 is important for the integrity of choroid.In the choroid sprout assay,lactate treated RPE/choroid complex showed a significant increase in angiogenesis compared to controls while lactate treated KO RPE/choroid complex showed no difference compared to their controls.For Q-PCR,most of the genes screened elevated their expression in GPR81−/−mice compared to WT mice,suggesting epigenetic modification may exist,which were confirmed by histone acetylation and HDACs activity assay.Conclusions:Taking together,the lactate receptor GPR81 in RPE is very important for maintaining homeostasis of the subretina.This novel discovery sheds new light on the relationship between metabolism and epigenetic modification. | Xiaojuan Yang Raphael Rouget Tang Zhu Christiane Quiniou Shasha Lv Suna Jung Francois Duhamel Houda Tahiri Samy Omri Baraa Noueihed Xin Hou JoséCarlos Rivera Mathieu Nadeau-Vallée Pierre Lachapelle Sylvain Chemtob | 2018 | Annals of Eye Science2018，，1： | 0 |
| 16 | Ventilation practices in burn patients—an international prospective observational cohort study显示文摘Background:It is unknown whether lung-protective ventilation is applied in burn patients and whether they benefit from it.This study aimed to determine ventilation practices in burn intensive care units(ICUs)and investigate the association between lung-protective ventilation and the number of ventilator-free days and alive at day 28(VFD-28).Methods:This is an international prospective observational cohort study including adult burn patients requiring mechanical ventilation.Low tidal volume(V_(T))was defined as V_(T)≤8 mL/kg predicted body weight(PBW).Levels of positive end-expiratory pressure(PEEP)and maximum airway pressures were collected.The association between V_(T) and VFD-28 was analyzed using a competing risk model.Ventilation settings were presented for all patients,focusing on the first day of ventilation.We also compared ventilation settings between patients with and without inhalation trauma.Results:A total of 160 patients from 28 ICUs in 16 countries were included.Low V_(T) was used in 74%of patients,median V_(T) size was 7.3[interquartile range(IQR)6.2–8.3]mL/kg PBW and did not differ between patients with and without inhalation trauma(p=0.58).Median VFD-28 was 17(IQR 0–26),without a difference between ventilation with low or high V_(T)(p=0.98).All patients were ventilated with PEEP levels≥5 cmH_(2)O;80%of patients had maximum airway pressures<30 cmH_(2)O.Conclusion:In this international cohort study we found that lung-protective ventilation is used in the majority of burn patients,irrespective of the presence of inhalation trauma.Use of low V_(T) was not associated with a reduction in VFD-28.Trial registration:Clinicaltrials.gov NCT02312869.Date of registration:9 December 2014. | Gerie J.Glas Janneke Horn Markus W.Hollmann Benedikt Preckel Kirsten Colpaert Manu Malbrain Ary Serpa Neto Karim Asehnoune Marcello Gamma de Abreu Ignacio Martin-Loeches Paolo Pelosi Folke Sjoerg Jan M.Binnekade Berry Cleffken Nicole P.Juffermans Paul Knape Bert G.Loef David P.Mackie Perenlei Enkhbaatar Nadia Depetris Anders Perner Eva Herrero Lucia Cachafeiro Marc Jeschke Jeffrey Lipman Matthieu Legrand Johannes Horter Athina Lavrentieva Alex Kazemi Anne Berit Guttormsen Frederik Huss Mark Kol Helen Wong Therese Starr Luc De Crop Wilson de Oliveira Filho Joa Manoel Silva Junior Cintia M.C.Grion Marjorie Burnett Frederik Mondrup Francois Ravat Mathieu Fontaine Renan Le Floch Mathieu Jeanne Morgane Bacus Maite Chaussard Marcus Lehnhardt Bassem Daniel Mikhail Jochen Gille Aidan Sharkey Nicole Trommel Auke C.Reidinga Nadine Vieleers Anna Tilsley Henning Onarheim Maria Teresa Bouza Alexander Agrifoglio Filip Fredén Tina Palmieri Lynda E.Painting Marcus J.Schultz LAMiNAR investigators | 2021 | Burns & Trauma2021，9，1： | 0 |
| 17 | 家族性主动脉瘤/夹层动脉瘤合并动脉导管未闭的遗传机制显示文摘目的在16p13-12.1位点20 cm的区域内明确致病基因,了解基因型和临床表型的关系。方法采用双向DNA直接测序法筛选候选基因;运用免疫组化和蛋白免疫印迹法等了解突变基因的表达情况。运用质粒重组及体外表达方法获得野生型和突变型蛋白,使用免疫共沉淀法了解这两者的结合程度。结果在两个家系中发现编码平滑肌肌球蛋白的MYH11基因突变,所有TAAD和PDA患者均为突变基因携带者。在法国家系中发现两个突变。前者为剪切点供体杂合子突变,导致编码71个氨基酸的第32外显子完全缺失:第2个突变为第37外显子上的1个点突变,导致精氨酸变为谷氨酸。在美国家系中发现1个杂合子突变,为第28外显子上编码24个氨基酸的72个碱基缺失。在法国患者的病变动脉标本上运用蛋白免疫印迹法,发现野生型和突变型肌球蛋白蛋白共存,但有异常免疫组化表现。体外实验显示重组野生型和突变型蛋白不能正常结合。结论MYH11基因突变导致家族性TAAD合并PDA,野生型和突变型平滑肌肌球蛋白不能正常结合,推论杂合子突变导致“Dominant-negative”作用。 | 朱理敏 Roger VRANCKX Philippe KHAU VAN KIEN Alain LALANDE Nicolas BOISSET Flavie MATHIEU Mark WEGMAN Luke GLANCY Jean-Marie GASC Francois BRUNOTTE Patrick BRUNEVAL Jean-Eric WOLF Jean-Baptiste MICHEL Xavier JEUNEMAITRE | 2007 | 上海医学2007，30，S1： | 0 |
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