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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Environmental magnetism: Principles and applications显示文摘 | Liu Qingsong Roberts Andrew P Larrasoa?a Juan C Banerjee Subir K Guyodo Yohan Tauxe Lisa Oldfield Frank | 2012 | EN2012，，4： | 3 |
| 3 | A conformationally sensitive GHR antibody : impact on GH signaling and GHR proteolysis显示文摘 | Jiang J Wang X He K Li X Chen C M Sayeski P P Waters M J Frank S J | 2004 | Mol Endocrinol2004，18，12： | 1 |
| 4 | Plankton patchiness in highfrequency internal waves 显示文摘 | Lennert Cody C E Franks P J S | 1999 | Marine Ecology Progress Series1999，186，： | 1 |
| 5 | A general kinetic model for quantitative perfusion imaging woth arterial spin labeling 显示文摘 | Buxton R B Frank L P Wong E C et aI | 1998 | Magn Reson Med1998，40，3： | 1 |
| 6 | Origin and migration of brines from Paleozoic strata in Central Tarim, China: constraints from 87Sr/86Sr, δD, δ18O and water chemistry 显示文摘 | Cai C Franks S G Aagaard P | 2001 | Applied Geochemistry2001，16，9： | 1 |
| 7 | Legacy integration changing perspective显示文摘 | FRANK P C | 2000 | IEEE SOft- ware2000，17，2： | 1 |
| 8 | Testing the Value of Customization:When Do Customers Really Prefer Products Tailored to Their Preferences?显示文摘 | Franke N Keinz P Steger C J | 2009 | Journal of Marketing2009，73，5： | 1 |
| 9 | Implementation of quantittative perfusion imaging techniques for function brin mapping using pulsed arterial spin labeling显示文摘 | Wong E C Buxton R B Frank L P | 1997 | NMR Biomed1997，10，45： | 1 |
| 10 | Neuron-specific enolase increase in cerebral and systemic circulation following focal ischemia显示文摘 | FRANK C B ROBERT K C WILLIAM J P | 1993 | Brain Res1993，623，1： | 1 |
| 11 | Origin and migration of brines from Paleozoic strata in Central Tarim,China: constraints from 87 Sr/S6 St, δD, δ18 O and water chemistry显示文摘 | Cai C Franks S G Aagaard P | 2001 | Applied Geochemis- try2001，16，： | 1 |
| 12 | Macrophage-induced apoptosis limits endovascular trophoblast invasion in the uterine wall of preeclamptic women显示文摘 | REISTER F FRANK H G KINGDOM J C P | 2001 | Lab Invest2001，81，8： | 1 |
| 13 | Evolution of chronic dysphagia following treatment for head and neck cancer显示文摘 | Nguyen N P Moltz C C Frank C | 2006 | Oral Oncol2006，42，4： | 1 |
| 14 | Osteoporotic Vertebral Fractures and Collapse With Intravertebral Vacuum Sign (Kümmel’s Disease)显示文摘 | Pappou Ioannis P Papadopoulos Elias C Swanson Andrew N Cammisa Frank P Girardi Federico P | 2008 | Orthopedics (Online)2008，，1： | 1 |
| 15 | Towards a molecular risk map-Recent advances on the etiology of inflammatory bowel disease显示文摘 | Rosenstiel P Sina C Franke A | 2009 | Semi Immunol2009，21，6： | 1 |
| 16 | Nonlinear observer design via an extended observer canonical form 显示文摘 | Ding X C Frank P M Guo L M | 1990 | Systems & Control Letters1990，15，4： | 1 |
| 17 | Limiting burn extension by transient inhibition of Connexin43 expression at the site of injury显示文摘 | Coutinho P Qiu C Frank S | 2005 | Br J Plast Surg2005，58，5： | 1 |
| 18 | Harnessing in vivo siRNA delivery for drug discovery and therapeutic development 显示文摘 | FRANK Y MARTIN C W LU P Y | 2006 | DDT2006，11，12： | 1 |
| 19 | Kinematics of revolving-knife disk-type sugarcane basecutter-1显示文摘 | Moses Frank Oduori Jun Sakai Gupta C P | 1992 | AMA1992，23，4： | 1 |
| 20 | High surface area substrates for DNA arrays显示文摘 | Glazer M Frank C Vinci R P | 1999 | Materials Research Society Symposium -Proceedings1999，，576： | 1 |
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