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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 3 | Cholangiocarcinoma, gone without the Wnt?显示文摘Cholangiocarcinoma(CCA) is a relatively rare malignancy of the intra- or extra-hepatic bile ducts that is classified according to its anatomical localization as intrahepatic, perihilar or distal. Overall, CCA has a dismal prognosis due to typical presentation at an advanced irresectable stage, lack of effective non-surgical treatments, and a high rate of disease recurrence. CCA frequently arises on a background of chronic liver inflammation and cholestasis. Chronic inflammation is accompanied by enhanced cell turnover with generation of additional inflammatory stimuli, and a microenvironment rich in pro-inflammatory mediators and proliferative factors that enable accumulation of mutations, transformation and expansion of mutated cells. A recent study by Boulter et al implicates the Wnt signaling cascade in cholangiocarcinogenesis. Wnt ligands Wnt7 B and Wnt10 A were found to be highly overexpressed in human CCA tissue. Wnt7 B protein was present throughout the tumor stroma, and often co-localized with a subset of CD68+ macrophages. To address in a direct manner whether Wnt signaling is engaged in development of CCA, Boulter et al explored the Wnt signaling pathway in an experimental model that recapitulates the multi-stage progression of human CCA.Wnt ligands found to be elevated in human CCA were also upregulated during the course of CCA development following thioacetamide treatment. Wnt10 a increased during the(pre-cancerous) regenerative phase, while Wnt7 b induction paralleled tumor growth. Along with upregulation of target genes, the findings demonstrate that the canonical Wnt pathway is progressively activated during cholangio-carcinogenesis. Macrophage depletion,eliminating a major source of Wnt7 b, prevented activation of the canonical Wnt cascade, and resulted in reduced number and volume of tumors in this model. Moreover,specific inhibitors of the canonical Wnt pathway(ICG-001 and C-59) caused reduction of tumor area and number,in xenograft and thioacetamide models of CCA. The aggregated findings show that experimental, and presumably human CCA, is a Wnt-driven tumor. Modulation of Wnt signaling, alone or in combination with surgicalor chemotherapy approaches, holds promise in the management of this fatal malignancy. | Anne T R Noll Thorsten Cramer Steven W M Olde Damink Frank G Schaap | 2016 | World Journal of Hepatology2016，8，26： | 3 |
| 4 | Prosthetic above-knee femoropopliteal bypass grafting: Five-year results of a randomized trial显示文摘 | Richard M Green William M Abbott Teruo Matsumoto Jock R Wheeler Normand Miller Frank J Veith Sam Money H Edward Garrett | 2000 | Journal of Vascular Surgery2000，，： | 2 |
| 5 | Optical fiber Bragg gratings for tunnel surveillance显示文摘 | NELLEN P M FRANK A BRONNIMANN R | 2000 | SPIE2000，3986，： | 2 |
| 6 | Stomach contents of juvenile Cobia, Rachycentron canadum, from the northern Gulf of Mexico 显示文摘 | Franks J S Garber N M Warren J R | 1996 | Fishery Bulletin1996，94，2： | 1 |
| 7 | Oxidation of thioacetamide by ferrate(VI)显示文摘 | Frank J M | 2000 | Marine Chemistry2000，70，1： | 1 |
| 8 | Neural stem cells as a novel platform for tumor-specific delivery of therapeutic antibodies显示文摘 | FRANK R T EDMISTON M KENDALL S E | 2009 | PLoS One2009，4，12： | 1 |
| 9 | Geographic origin of meat-elements of an analytical approach to its authentication显示文摘 | Franke B M Gremaud G Hadorn R | 2005 | European Food Research and Technology2005，221，： | 1 |
| 10 | Podophyllotoxin 显示文摘 | Canel C Moraes R M Frank E D | 2000 | Phytochem2000，54，2： | 1 |
| 11 | Growth hormone receptor is a target for presenilin-dependent gam- ma-secretase cleavage 显示文摘 | Cowan J W Wang X D Guan R He K Jiang J Baumann G Black R A Wolfe M S Frank S J | 2005 | J Biol Chem2005，280，19： | 1 |
| 12 | Modified lignin in tobacco and poplar plants over- expressing the Arabidopsis gene encoding ferulate 5 - hydroxylase显示文摘 | Franke R McMichael C M Meyer K | 2000 | Plant J2000，22，3： | 1 |
| 13 | Carbon fibers:Precursors,manufacturing,and properties显示文摘 | Frank E Hermanutz F Buchmeiser M R | 2012 | Macromol Mater Eng2012，297，6： | 1 |
| 14 | The magnitude of Late Paleozoic glacioeustatic fluctuations: A synthesis显示文摘 | Rygel M C Fielding C R Frank T D | 2008 | Journal of Sedimentary Research2008，78，8： | 1 |
| 15 | The generation of movement patterns during the acquisition of a pursuit tracking task显示文摘 | FRANK I M WILLBERG R B | 1982 | Human Mov Sci1982，1，： | 1 |
| 16 | Quasiregular mappings and WT-classes of differential forms On Riemannian manifolds显示文摘 | Franke D Martio O Miklyukov V M Vuorinen M Wisk R | 2002 | Pacific Journal of Mathematics2002，202，1： | 1 |
| 17 | Absorption of a mixture of volatile organic compounds(VOCs) in aqueous solutions of soluble cutting oil显示文摘 | FRANK L LUC M JEAN-CLAUDE R | 2008 | Bioresource Technology2008，99，6： | 1 |
| 18 | 10Be records of sediment cores from the high northern latitudes: implications for environmental and climatic changes显示文摘 | EISENHAUER A SPIELHAGEN R F FRANK M | 1994 | Earth Planet Sci Lett1994，124，： | 1 |
| 19 | 60 Myr records of major elements and Pb-Nd isotopes from hydrogenous ferromanganese crusts: reconstruction of seawater paleochemistry显示文摘 | FRANK M ONION R K HEIN J R | 1999 | Geochinica et Cosmochimica Acta1999，63，： | 1 |
| 20 | Equilibria,kinetics,and mechanism in the bicarbonate activation ofhydrogen peroxide :oxidation of sulfides by peroxymonocarbonate显示文摘 | Richardson D E Yao H R Frank K M ei al | 2000 | Journal of the American Chemical Society2000，122，8： | 1 |
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