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| 1 | High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis显示文摘AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. | Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 3 | Bio-ethanol, a suitable fuel to produce hy- drogen for a molten carbonate fuel cell 显示文摘 | FRUSTERI F FRENI S | 2007 | Journal of Power Sources2007，173，1： | 1 |
| 4 | Ethanolsteamreforminginamoltencarbonatefuelcell:athermodynamicapproach显示文摘 | FreniS MaggioG CavallaroS | 1996 | Journalofpowersources1996，62，1： | 1 |
| 5 | H2 production for MC fuel cell by steam reforming of ethanol over MgO supported Pd, Rh, Ni and Co catalysts 显示文摘 | Frusteri F Freni S Spadaro L | 2004 | Catal Com-mun2004，5，： | 1 |
| 6 | Technology up date and new strategies on fuel cells显示文摘 | CACCIOLA G ANTONUCCI V FRENI S | 2001 | J of Power Sources2001，100，： | 1 |
| 7 | Catalytic features of Rh and Ni supported catalysts in the steam reforming of glycerol to produce hydrogen显示文摘 | Chiodo V Freni S Galvagno A | 2010 | Applied Catalysis A: General2010，381，12： | 1 |
| 8 | Technology up Date and New Strategies on Fuel Cells显示文摘 | Cacciola G Antonucci V Freni S | 2001 | J Power Source2001，100，1： | 1 |
| 9 | Steam reforming of bio-ethanol on alkali-doped Ni/MgO catalysts:hydrogen production for MC fuel cell 显示文摘 | Frusteri F Freni S Chiodo V | 2004 | Appl Catal A: Gen2004，270，： | 1 |
| 10 | Steam and auto- thermal reforming of bio-ethanol over MgO and CeO2 Ni supported catalysts显示文摘 | Frusteri F Freni S Chiodo V | 2006 | Int J Hydrogen Energy2006，31，： | 1 |
| 11 | H2 production for MC fuel cell by steam reforming of ethanol over MgO supported Pd, Rh, Ni and Co catalysts显示文摘 | Frusteri F Freni S Spadaro L | 2004 | Catalysis Communications2004，，5： | 1 |
| 12 | A dynamic model of heat and mass transfer in a double-bed adsorption machine with internal heat recovery 显示文摘 | MAGGIO G FRENI A RESTUCCIA G | 2006 | International Journal of Refrigeration2006，，29： | 1 |
| 13 | Seat belt injuries of the abdominal aorta in adults-case report and literature review显示文摘 | Freni L Barbetta I Mazzaccaro D | 2013 | Vasc Endovascular Surg2013，47，2： | 1 |
| 14 | Exposure to high fluoride concentrations in drinking water is associated with decreased birth rates显示文摘 | Freni SC | | 0，，1： | 1 |
| 15 | Uncertainty assessment of an integrated urban drainage model 显示文摘 | Freni G Mannina G Viviani G | 2009 | Journal of Hydrology2009，373，34： | 1 |
| 16 | Synthesis and characterization of proton-conducting materials containing dodecatungstophosphoric and dodecatungstosilic acid supported on silica显示文摘 | STAITI P FRENI S HOCEVAR S | 1999 | JournalofPowerSources1999，79，2： | 1 |
| 17 | Integrated urban water modelling with uncertainty analysis 显示文摘 | Mannina G Freni G Viviani G | 2006 | Water Science and Technology2006，54，67： | 1 |
| 18 | 显示文摘 | Cavallaro S Chiodo V Freni S | 2003 | Applied Catal A2003，249，： | 1 |
| 19 | Rh based catalysts for indirect internal reforming ethanol applications in molten carbonate fuel cells 显示文摘 | FRENI S | 2001 | J Power Sources2001，94，： | 1 |
| 20 | Prospetive evalua- tion of ultrasound and biochemical-based muhivariable models for the prediction of late pre-eclampsia 显示文摘 | Farina A Rapacchia G Freni SA | 2011 | Prena- tal Diagn2011，31，12： | 1 |
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