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| 1 | Effect of nutritional counselling on hepatic,muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease显示文摘AIM: To assess the effectiveness of the current UK clinical practice in reducing hepatic fat (IHCL). METHODS: Whole body MRI and 1H MRS were obtained, before and after 6 mo nutritional counselling, from liver, soleus and tibialis muscles in 10 subjects with non-alcoholic fatty liver disease (NAFLD). RESULTS: A 500 Kcal-restricted diet resulted in an average weight loss of 4% (-3.4 kg,) accompanied by significant reductions in most adipose tissue (AT) depots, including subcutaneous (-9.9%), abdominal subcutaneous (-10.2%) and intra-abdominal-AT (-11.4%). Intramyocellular lipids (IMCL) were significantly reduced in the tibialis muscle (-28.2%). Decreases in both IHCL (-39.9%) and soleus IMCL (-12.2%) content were also observed, although these were not significant. Several individuals showed dramatic decreases in IHCL, while others paradoxically showed increases in IHCL content. Changes in body composition were accompanied by improvements in certain liver function tests: serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Significant correlations were found between decreases in IHCL and reductions in both intra-abdominal and abdominal subcutaneous AT. Improvements in liver function tests were associated with reductions in intra-abdominal AT, but not with changes in IHCL. CONCLUSION: This study shows that even a very modest reduction in body weight achieved through lifestyle modification can result in changes in body fat depots and improvements in LFTs. | E Louise Thomas Audrey E Brynes Gavin Hamilton Nayna Patel Adam Spong Robert D Goldin Gary Frost Jimmy D Bell Simon D Taylor-Robinson | 2006 | World Journal of Gastroenterology2006，12，36： | 13 |
| 2 | Thermal decomposition of bauxite minerals: infrared emission spectroscopy of gibbsite显示文摘 | Kloprogge J T Ruan H D Frost R L | 2004 | Boehmite and Diaspore2004，37，6： | 1 |
| 3 | The behavior of hydroxyl units of synthetic goethite and its dehydroxylated product hematite显示文摘 | Ruan H D Frost R L Kloprogge J T | 2001 | Spectrochim Acta Part A2001，57，： | 1 |
| 4 | The route of nutritional support in the critical ill:physiological and economical considerations显示文摘 | Frost P Bihari D | 1997 | Nutrition1997，9，13： | 1 |
| 5 | Response of commercial leghorns to sodium aluminosilicate when fed different levels and sources of available phosphorus显示文摘 | ROLAND S D RABON H FROST T | 1990 | Poultry Science1990，69，12： | 1 |
| 6 | Benthic boundary layer macrofauna of Browns Bank, northwest Atlantic, as potential prey of juvenile benthic fish 显示文摘 | Wildish D J Wilson A J Frost B | 1992 | Canadian Journal of Fisheries and Aquatic Sciences1992，49，： | 1 |
| 7 | Determination of a Morphological Phase Diagram of Titania/titanate Nanostructures from Alkaline Hydrothermal Treatment of Degussa P25 显示文摘 | MORGAN D L ZHU H Y FROST R L | 2008 | Chem Mater2008，20，： | 1 |
| 8 | Movement quality and links to measures of fitness in firefighters显示文摘 | Me Gill S Frost D Andersen J | 2013 | Work2013，45，3： | 1 |
| 9 | Quantifying hook and loop interaction in textured geomembrane-geotextile systems 显示文摘 | Hebeler G L Frost J D Myers A T | 2005 | Geomembrane and Geotextile2005，23，1： | 1 |
| 10 | Electrochemical oxygen transfer during direct current arc welding 显示文摘 | Kim J H Frost R H Olson D L | 1998 | Welding Journal1998，77，12： | 1 |
| 11 | Immunohistochemical localization of survivin in benign cervical mucosa,cervical dysplasia,and invasive squamous cell carcinoma显示文摘 | Frost M Jarboe EA Orlicky D | | 0，，： | 1 |
| 12 | Fragmentation mechanisms based on single drop steam explosion experiments using flash X-ray radiography显示文摘 | Ciccarelli G Frost D L | 1994 | Nuclear Engineer-ing Design1994，146，： | 1 |
| 13 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 14 | Acute ingestion of resistant starch reduces food intake in healthy adults 显示文摘 | Bodinham C L Frost G S Robertson M D | 2010 | British Journal of Nutrition2010，103，6： | 1 |
| 15 | The route of nutritional support in the critical ill:physiological and economical considerations显示文摘 | FROST P BIHARI D | 1997 | Nutrition1997，9，13： | 1 |
| 16 | Strontium isotope geochemistry of groundwater in the central part of the Dakota (Great Plains) aquifer, USA显示文摘 | GOSSELINA D C HARVEYA F E FROST C | 2004 | Applied Geochemistry2004，19，： | 1 |
| 17 | Sensitive detection and typing of Chlamydia trachomatis using nested polymerase chain reaction 显示文摘 | Frost EH Deslandes S Bourgaux -Ramoisy D | 1993 | Genitourin Med1993，69，4： | 1 |
| 18 | The route of nutritional support in the critically ill: physiological and eeonemieal eonsiderations显示文摘 | Frost P Bihari D | 1997 | Nutrition1997，13，： | 1 |
| 19 | A scalable agent-based network measurement infrastructure显示文摘 | Wijata Y Niehaus D Frost V | 2000 | IEEE Communications Magazine2000，38，9： | 1 |
| 20 | The route of nutritional support in the critically ill: physiological and economical considerations 显示文摘 | Frost P Bihari D | 1997 | Nutrition1997，13，9： | 1 |
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