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| 1 | Regulation of microglial activation in stroke显示文摘当 ischemic 击发生时,氧和精力弄空触发事件的串联,包括导致深刻大脑损害的煽动性的回答, glutamate excitotoxicity,氧化压力,和 apoptosis。煽动性的反应贡献第二等的 neuronal 损坏,它在两尖锐 ischemic 损害和大脑功能的长期的恢复上施加实质的影响。Microglia 是在常常,在正常下面的监视器大脑微型环境调节的大脑的居民免疫者房间。一旦局部缺血发生, microglia 被激活生产有害并且二个抵抗调停人的 neuroprotective 调停人,和平衡决定受伤神经原的命运。microglia 的激活被定义为经典著作(M1 ) 或选择(M2 ) :M1 microglia 分泌支持 inflammatory cytokines (TNF, IL-23, IL-1, IL-12,等等) 并且加重 neuronal 损害,而 M2 显型支持反煽动性的回答,那是修理的。它有重要翻译价值调整 M1/M2 microglial 激活最小化有害效果或最大化保护的角色。这里,我们在 ischemic 击的上下文讨论在 microglia 和神经原之间的 microglia/macrophage 激活和相互作用的各种各样的管理者。 | Shou-cai ZHAO Ling-song MA Zhao-hu CHU Heng XU Wen-qian WU Fudong LIU | 2017 | Acta Pharmacologica Sinica2017，38，4： | 38 |
| 2 | Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition显示文摘 | Fudong Li Debiao Zhao Jihui Wu Yunyu Shi | 2014 | Cell Research2014，24，12： | 16 |
| 3 | Parallel architecture and optimization for discrete-event simulation of spike neural networks显示文摘Spike neural networks are inspired by animal brains,and outperform traditional neural networks on complicated tasks.However,spike neural networks are usually used on a large scale,and they cannot be computed on commercial,off-the-shelf computers.A parallel architecture is proposed and developed for discrete-event simulations of spike neural networks.Furthermore,mechanisms for both parallelism degree estimation and dynamic load balance are emphasized with theoretical and computational analysis.Simulation results show the effectiveness of the proposed parallelized spike neural network system and its corresponding support components. | TANG YuHua ZHANG BaiDa WU JunJie HU TianJiang ZHOU Jing LIU FuDong | 2013 | Science China(Technological Sciences)2013，56，2： | 5 |
| 4 | Age-related differences in interferon regulatory factor-4 and -5 signaling in ischemic brains of mice显示文摘 | Shou-cai ZHAO Chun WANG Heng XU Wen-qian WU Zhao-hu CHU Ling-song MA Ying-dong ZHANG Fudong LIU | 2017 | Acta Pharmacologica Sinica2017，38，11： | 4 |
| 5 | Effects of injection of anti-corticotropin release hormone serum in the lateral ventricles and electroacupuncture analgesia on pain threshold in rats with adjuvant arthritis显示文摘Rat models of adjuvant arthritis were established, and anti-corticotropin release hormone serum injection in the lateral ventricles and electroacupuncture at right Jiaji (EX-B2) were performed. The pain threshold was decreased at 45 and 60 minutes after injection of the anti-corticotropin release hormone serum. Electroacupuncture at Jiaji can resist this effect. Immunohistochemical staining results showed that the expression of corticotropin release hormone in the hypothalamic paraven-tricular nucleus was greater in the electroacupuncture + anti-corticotropin release hormone serum group compared with the anti-corticotropin release hormone serum group. The expression of corticotropin release hormone was correlated with the pain threshold. The effect of endogenous corticotropin release hormone in pain modulation can be obstructed by anti-corticotropin release hormone serum. The analgesia of electroacupuncture can partially resist the depressed pain threshold caused by injection of anti-corticotropin release hormone serum. The analgesic effect of elec-troacupuncture is associated with the corticotropin release hormone content in the hypothalamus. | Yunying Qiao Fudong Wu Jian Wang Xiaolu Cui Congcong Liu Xinlong Zhu | 2012 | Neural Regeneration Research2012，7，21： | 2 |
| 6 | A Preliminary Review on the Metallogeny of Pb-Zn Deposits in China显示文摘Lead and zinc resources are abundant in China, with the reserves of 100 million tons ranking only second in the world. There are more than 3000 lead-zinc mine areas nationwide. The classification of lead-zinc(Pb-Zn) deposits has been a highly controversial issue. From the standpoint of evaluating the potential of mineral resources, we construct a Pb-Zn deposit predictive type of classification scheme, and propose a Pb-Zn deposit comprehensive classification scheme(including 5 classes and 13 sub-types) that regards mineralization as the primary factor and the ore rock as secondary. According to the temporal and spatial distribution of Pb-Zn deposits, we conclude that a multi-period, multi-cycle orogenic environment is the most favorable for lead-zinc deposit growth, that the Proterozoic is the major eon for the growth of igneous-type deposits, the Paleozoic is an important development era for sedimentary Pb-Zn deposits, and the Mesozoic and Cenozoic are the heyday eras of magmatic type lead-zinc deposits. On this basis, we analyse the relationship between tectonic evolution and Pb-Zn metallogenic, and propose that the key factors determining geological mineralization are the metallogenic epoch of mineralization and tectonic environment, which determine the temporal and spatial distribution. | ZHANG Changqing LIU Huan WANG Denghong CHEN Yuchuan RUI Zongyao LOU Debo WU Yue JIA Fudong CHEN Zhenghui MENG Xuyang | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 1 |
| 7 | Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding显示文摘 | Juncheng Wang Su Qin Fudong Li Sai Li Wei Zhang Junhui Peng Zhiyong Zhang Qingguo Gong Jihui Wu Yunyu Shi | 2014 | Cell Research2014，24，7： | 0 |
| 8 | 二聚体RNA解旋酶CsdA的结构生物学研究及其C端区域的重要功能显示文摘文章简介RNA解旋酶Csd A在大肠杆菌50S核糖体的生物合成和低温下rpos的基因表达调控过程中发挥重要作用,然而一直以来人们并不清楚Csd A的结构和长片段C端区域的功能。 | Ling Xu Lijun Wang Junhui Peng Fudong Li Lijie Wu Beibei Zhang Mengqi Lv Jiahai Zhang Qingguo Gong Rongguang Zhang Xiaobing Zuo Zhiyong Zhang Jihui Wu 唐雅珺 施蕴渝 | 2018 | 科学新闻2018，0，4： | 0 |
| 9 | Structural and biochemical insights into human zinc finger protein AEBP2 reveals interactions with RBBP4显示文摘 | Aiai Sun Fudong Li Zhonghua Liu, Yiyang Jiang Jiahai Zhang Jihui Wu Yunyu Shi | 2018 | Protein & Cell2018，9，8： | 0 |
| 10 | Structural insights reveal the specific recognition of meiRNA by the Mei2 protein显示文摘In the fission yeast Schizosaccharomyces pombe,Mei2,an RNA-binding protein essential for entry into meiosis,regulates meiosis initiation.Mei2 binds to a specific non-coding RNA species,meiRNA,and accumulates at the sme2 gene locus,which encodes meiRNA.Previous research has shown that the Mei2 C-terminal RNA recognition motif(RRM3)physically interacts with the meiRNA 5'region in vitro and stimulates meiosis in vivo.However,the underlying mechanisms still remain elusive.We first employed an in vitro crosslinking and immunoprecipitation sequencing(CLIP-seq)assay and demonstrated a preference for U-rich motifs of meiRNA by Mei2 RRM3.We then solved the crystal structures of Mei2 RRM3 in the apo form and complex with an 8 mer RNA fragment,derived from meiRNA,as detected by in vitro CLIP-seq.These results provide structural insights into the Mei2 RRM3-meiRNA complex and reveal that Mei2 RRM3 binds specifically to the Uuc(U)sequence.Furthermore,a structure-based Mei2 mutation,Mei2F644A causes defective karyogamy,suggesting an essential role of the RNA-binding ability of Mei2 in regulating meiosis. | Siyuan Shen Yanze jian Zhaokui Cai Fudong Li Mengqi Lv Yongrui Liu Jihui Wu Chuanhai Fu Yunyu Shi | 2022 | Journal of Molecular Cell Biology2022，14，5： | 0 |
| 11 | Highly efficient and anti-poisoning single-atom cobalt catalyst for selective hydrogenation of nitroarenes显示文摘Developing non-precious metal catalysts to selectively reduce functionalized nitroarenes with high efficiency is urgently desirable for the production of value-added amines.Herein,we report a novel,efficient,anti-poisoning single-atom cobalt catalyst(Co-NAC)for the highly selective hydrogenation of the nitro to amino group for nitroarenes baring various functional groups,including vinyl,cyano,and halogen.Using a combination of structure characterization techniques,we have confirmed that the cobalt species are predominantly present in the form of four-coordinated Co single sites anchored on nitrogen-assembly carbon(NAC)as the ordered mesoporous support.Co-NAC catalysts enable the full conversion and>99%selectivity with molecular H2 as a green reductant under mild conditions(80℃,2 MPa H2).As for the selective hydrogenation of 3-nitrostyrene,Co-NAC catalyst affords high catalytic productivity(19.7 h-1),which is superior to the cobalt nanoparticles(NPs)catalysts and most of the recently reported Co-based catalysts.This is attributed to the highly accessible atomically-dispersed Co active sites,the high surface area with ordered-mesoporous morphology and the prominent high content of nitrogen dopants.Notably,Co-NAC catalyst displays resistance towards sulfur-containing poisons(20 equivalents)and strong non-oxidizing acid(8 M),showing great potential for continuous application in the chemical industry. | Yuemin Lin Renfeng Nie Yuting Li Xun Wu Jiaqi Yu Shaohua Xie Yajing Shen Shanjun Mao Yuzhuo Chen Dan Lu Zongbi Bao Qiwei Yang Qilong Ren Yiwen Yang Fudong Liu Long Qi Wenyu Huang Zhiguo Zhang | 2022 | Nano Research2022，15，12： | 0 |
| 12 | Bitcoin Network Measurement and a New Approach to Infer the Topology显示文摘Bitcoin has made an increasing impact on the world's economy and financial order,which attracted extensive attention of researchers and regulators from all over the world.Most previous studies had focused more on the transaction layer,but less on the network layer.In this paper,we developed BNS(Bitcoin Network Sniffer),which could find and connect nodes in the Bitcoin network,and made a measurement in detail.We collected nearly 4.1 million nodes in 1.5 hours and identified 9,515 reachable nodes.We counted the reachable nodes'properties such as:service type,port number,client version and geographic distribution.In addition,we analyzed the stability of the reachable nodes in depth and found nearly 60%kept stable during 15 days.Finally,we proposed a new approach to infer the Bitcoin network topology by analyzing the Neighbor Addresses of Adjacent Nodes and their timestamps,which had an accuracy over 80%. | Ruiguang Li Jiawei Zhu Dawei Xu Fudong Wu Jiaqi Gao Liehuang Zhu | 2022 | China Communications2022，19，10： | 0 |
| 13 | BUES: A Blockchain-Based Upgraded Email System显示文摘This paper focuses on the improvement of traditional email system architecture with the help of blockchain technology in the existing network environment. The improved system architecture can better improve the security and stability of the system. The email content is extracted and stored in the blockchain network to achieve regulatory traceability between the email service provider and the higher-level organization. In turn, A Blockchain-based Upgraded Email System(BUES) is proposed. The defects of the existing traditional email system are addressed. Firstly, the threat model of the traditional email system is analyzed, and solutions are proposed for various threats. Then a system architecture consisting of the blockchain network, email servers, and users are constructed. The implementation of BUES is carried out, and the related experimental process and algorithm steps are given. After the experimental analysis, it is shown that BUES can ensure the security, reliability, efficiency, and traceability of email transmission. | Dawei Xu Fudong Wu Liehuang Zhu Ruiguang Li Jiaqi Gao Yijie She | 2022 | China Communications2022，19，10： | 0 |
| 14 | CLASSIFICATION, PROGRESSIVE STAGE AND COMBINED TREATMENT OF PERIPHERAL FACIAL PARALYSIS显示文摘A combined method using acupuncture,Chinese herbs and Western medicine inthe treatment of peripheral facial paralysis is formulated from the author’s clinical experience duringmore than 20 years period.Two stages and four types are divided separately according to the develop-ment of the disorder and the lesion level of the facial nerve。which are different from the classificationsin the common textbooks.Out of the whole series of 718 cases,99.58%of the patients got cured andno one had been treated ineffectively. | Liu Yutan Wu Fudong, Acupuncture Department of Shandong College of TCM, 53 Jingshi Road, Jinan 250014, China | 1993 | World Journal of Acupuncture-Moxibustion1993，3，3： | 0 |
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