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| 1 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 2 | Selective hydrogenation of nitrobenzene top-Aminophenol by the polymer-supported palladium-based mono- and bimetallic catalyst显示文摘 | Yan Gao Fudong Wang Shijian Liao Daorong Yu | 1998 | Reaction Kinetics and Catalysis Letters1998，，2： | 1 |
| 3 | Superior and safer lithium sulfur batteries realized by robust polysulfides-retarding dam with high flame retardance显示文摘The unparalleled energy density has granted lithium-sulfur batteries(LSBs)with attractive usages.Unfortunately,LSBs still face some unsurpassed challenges in industrialization,with polysulfides shuttling,dendrite growth and thermal hazard as the major problems triggering the cycling instability and low safety.With the merit of convenience,the method of designing functional separator has been adapted.Concretely,the carbon aerogel confined with CoS_(2)(CoS_(2)-NCA)is constructed and coated on Celgard separator surface,acquiring CoS_(2)-NCA modified separator(CoS_(2)-NCA@C),which holds the promoted electrolyte affinity and flame retardance.As revealed,CoS_(2)-NCA@C cell gives a high discharge capacity 1536.9 mAh/g at 1st cycle,much higher than that of Celgard cell(987.1 mAh/g).Moreover,the thermal runaway triggering time is dramatically prolonged by 777.4 min,corroborating the promoted thermal safety of cell.Noticeably,the higher coulombic efficiency stability and lower overpotential jointly confirm the efficacy of CoS_(2)-NCA@C in suppressing the lithium dendrite growth.Overall,this work can provide useful inspirations for designing functional separator,coping with the vexing issues of LSBs. | Junling Wang Yanfang Cao Zhirong Wang Yinquan Zhao Chuang He Fudong Zhao Chaoling Han Shui Yu | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 4 | Highly efficient and anti-poisoning single-atom cobalt catalyst for selective hydrogenation of nitroarenes显示文摘Developing non-precious metal catalysts to selectively reduce functionalized nitroarenes with high efficiency is urgently desirable for the production of value-added amines.Herein,we report a novel,efficient,anti-poisoning single-atom cobalt catalyst(Co-NAC)for the highly selective hydrogenation of the nitro to amino group for nitroarenes baring various functional groups,including vinyl,cyano,and halogen.Using a combination of structure characterization techniques,we have confirmed that the cobalt species are predominantly present in the form of four-coordinated Co single sites anchored on nitrogen-assembly carbon(NAC)as the ordered mesoporous support.Co-NAC catalysts enable the full conversion and>99%selectivity with molecular H2 as a green reductant under mild conditions(80℃,2 MPa H2).As for the selective hydrogenation of 3-nitrostyrene,Co-NAC catalyst affords high catalytic productivity(19.7 h-1),which is superior to the cobalt nanoparticles(NPs)catalysts and most of the recently reported Co-based catalysts.This is attributed to the highly accessible atomically-dispersed Co active sites,the high surface area with ordered-mesoporous morphology and the prominent high content of nitrogen dopants.Notably,Co-NAC catalyst displays resistance towards sulfur-containing poisons(20 equivalents)and strong non-oxidizing acid(8 M),showing great potential for continuous application in the chemical industry. | Yuemin Lin Renfeng Nie Yuting Li Xun Wu Jiaqi Yu Shaohua Xie Yajing Shen Shanjun Mao Yuzhuo Chen Dan Lu Zongbi Bao Qiwei Yang Qilong Ren Yiwen Yang Fudong Liu Long Qi Wenyu Huang Zhiguo Zhang | 2022 | Nano Research2022，15，12： | 0 |
| 5 | Modeling potential wetland distributions in China based on geographic big data and machine learning algorithms显示文摘Climate change and human activities have reduced the area and degraded the functions and services of wetlands in China.To protect and restore wetlands,it is urgent to predict the spatial distribution of potential wetlands.In this study,the distribution of potential wetlands in China was simulated by integrating the advantages of Google Earth Engine with geographic big data and machine learning algorithms.Based on a potential wetland database with 46,000 samples and an indicator system of 30 hydrologic,soil,vegetation,and topographic factors,a simulation model was constructed by machine learning algorithms.The accuracy of the random forest model for simulating the distribution of potential wetlands in China was good,with an area under the receiver operating characteristic curve value of 0.851.The area of potential wetlands was 332,702 km^(2),with 39.0%of potential wetlands in Northeast China.Geographic features were notable,and potential wetlands were mainly concentrated in areas with 400-600 mm precipitation,semi-hydric and hydric soils,meadow and marsh vegetation,altitude less than 700 m,and slope less than 3°.The results provide an important reference for wetland remote sensing mapping and a scientific basis for wetland management in China. | Hengxing Xiang Yanbiao Xi Dehua Mao Tianyuan Xu Ming Wang Fudong Yu Kaidong Feng Zongming Wang | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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